Abstract (Expand)

Chemical reaction networks are ubiquitous in biology, and their dynamics is fundamentally stochastic. Here, we present the software library pSSAlib, which provides a complete and concise implementation ...

Authors: Lutz Brusch, Ostrenko Oleksandr,Incardona Pietro,Ramaswamy Rajesh,Sbalzarini Ivo F.

Date Published: 4th Dec 2017

Journal: PLoS Comput Biol

Abstract (Expand)

Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell cycle progression, ...

Authors: Lorenz Adlung, Marie-Christine Wagner, Sajib Chakraborty, Hauke Busch, Marcel Schilling, Kar S.,She B.,Bao J.,Lattermann S.,Boerries M.,Wuchter P.,Ho A. D.,Timmer J.,Hofer T.,Klingmuller U.

Date Published: 27th Jan 2017

Journal: Mol Syst Biol

Abstract (Expand)

Plants sense the light environment through an ensemble of photoreceptors. Members of the phytochrome class of light receptors are known to play a critical role in seedling establishment, and are among ...

Author: Yang Deyue,Seaton Daniel D.,Krahmer Johanna,Halliday Karen J.

Date Published: 5th Jul 2016

Journal: Proc Natl Acad Sci USA

Abstract (Expand)

The interaction between the stromal cell-derived factor-1 alpha (SDF-1alpha, CXCL12) and its chemokine receptor CXCR4 has been reported to regulate stem cell migration, mobilization and homing. The ...

Authors: Rainer Saffrich, Wuchter P.,Leinweber C.,Hanke M.,Eckstein V.,Ho A. D.,Grunze M.,Rosenhahn A.

Date Published: 14th Dec 2013

Journal: Cell Tissue Res

Abstract (Expand)

Our quantitative knowledge of carbon fluxes in the long slender bloodstream form (BSF) Trypanosoma brucei is mainly based on non-proliferating parasites, isolated from laboratory animals and kept in ...

Authors: Jurgen Haanstra, Barbara Bakker, van Tuijl A.,van Dam J.,van Winden W.,Tielens A. G.,van Hellemond J. J.

Date Published: 8th May 2012

Journal: Int J Parasitol

Abstract (Expand)

BACKGROUND: Ontologies are being developed for the life sciences to standardise the way we describe and interpret the wealth of data currently being generated. As more ontology based applications begin ...

Authors: Stuart Owen, Katy Wolstencroft, Jupp Simon,Horridge Matthew,Iannone Luigi,Klein Julie,Schanstra Joost,Stevens Robert

Date Published: 25th Jan 2012

Journal: BMC bioinformatics

Abstract (Expand)

In Bacillus subtilis the σB mediated general stress response provides protection against various environmental and energy related stress conditions. To better understand the general stress response, ...

Authors: Ulf Liebal, Praveen Kumar Sappa, Thomas Millat, Leif Steil, Uwe Voelker, Olaf Wolkenhauer, Homuth Georg

Date Published: 2012

Journal: Mol. BioSyst.

Abstract (Expand)

Pseudomonas putida KT2440 is a completely sequenced biosafety strain that has retained its capability to survive and function in the environment. The global mRNA expression profiles of the KT2440 strain ...

Authors: Sarah Frank, Jens Klockgether, Burkhard Tuemmler, Hagendorf P.,Geffers R.,Schock U.,Pohl T.,Davenport C. F.

Date Published: 28th Feb 2011

Journal: Environ Microbiol

Abstract (Expand)

Several lactic acid bacteria use homolactic fermentation for generation of ATP. Here we studied the role of the lactate dehydrogenase enzyme on the general physiology of the three homolactic acid ...

Authors: Tomas Fiedler, Martijn Bekker, Maria Jonsson, Ibrahim Mehmeti, Ingolf Nes, Jeroen Hugenholtz, Bernd Kreikemeyer, Pritzschke Anja,Siemens Nikolai

Date Published: 25th Nov 2010

Journal: Not specified

Abstract (Expand)

The majority of all proteins of a living cell is active in complexes rather than in an isolated way. These protein-protein interactions are of high relevance for many biological functions. In addition ...

Authors: Uwe Voelker, Joerg Stuelke, Meyer Frederik M,Gerwig Jan,Hammer Elke,Herzberg Christina,Commichau Fabian M

Date Published: 20th Aug 2010

Journal: Not specified

Abstract (Expand)

Summary The PrsA protein is a membrane-anchored peptidyl-prolyl cis-trans isomerase in Bacillus subtilis and most other Gram-positive bacteria. It catalyses the post-translocational folding of exported ...

Authors: Bogumila Marciniak, Oscar Kuipers, Hyyryläinen Hanne-Leena,Dahncke Kathleen,Pietiäinen Milla,Courtin Pascal,Vitikainen Marika,Seppala Raili,Otto Andreas,Becher Dörte,Chapot-Chartier Marie-Pierre,Kontinen Vesa P

Date Published: 4th May 2010

Journal: Mol. Microbiol.

Abstract (Expand)

In the three domains of life, the Sec, YidC/Oxa1, and Tat translocases play important roles in protein translocation across membranes and membrane protein insertion. While extensive studies have been ...

Authors: Jan Maarten Van Dijl, Yuan Jijun,Zweers Jessica C,Dalbey Ross E

Date Published: 16th Jun 2009

Journal: Cell. Mol. Life Sci.

Abstract (Expand)

Bacterial growth requires equilibrated concentration of C, N and P sources. This work shows a phosphate control over the nitrogen metabolism in the model actinomycete Streptomyces coelicolor. Phosphate ...

Authors: Antonio Rodríguez-García, Juan-Francisco Martin, Sola-Landa Alberto,Apel Kristian,Santos-Beneit Fernando

Date Published: 24th Mar 2009

Journal: Nucleic Acids Res.

Abstract (Expand)

Gel-based proteomics is a useful approach for visualizing the responses of bacteria to stress and starvation stimuli. In order to face stress/starvation, bacteria have developed very complicated gene ...

Authors: Michael Hecker, Reder Alexander,Fuchs Stephan,Pagels Martin,Engelmann Susanne

Date Published: 20th Feb 2009

Journal: Res. Microbiol.

Abstract (Expand)

MOTIVATION: High-accuracy mass spectrometry is a popular technology for high-throughput measurements of cellular metabolites (metabolomics). One of the major challenges is the correct identification ...

Authors: Rainer Breitling, Rogers Simon,Scheltema Richard A,Girolami Mark

Date Published: 18th Dec 2008

Journal: Bioinformatics

Abstract (Expand)

The prevalences of three sulfonamide resistance genes, sul1, sul2, and sul3 and sulfachloropyridazine (SCP) resistance were determined in bacteria isolated from manured agricultural clay soils and ...

Authors: William Gaze, Elizabeth Wellington, Byrne-Bailey K G,Kay P,Boxall A B A,Hawkey P M

Date Published: 8th Dec 2008

Journal: Antimicrob. Agents Chemother.

Abstract (Expand)

The transport of inorganic phosphate (P(i)) is essential for the growth of all organisms. The metabolism of soil-dwelling Streptomyces species, and their ability to produce antibiotics and other secondary ...

Authors: Antonio Rodríguez-García, Juan-Francisco Martin, Santos-Beneit Fernando,Franco-Domínguez Etelvina

Date Published: 1st Aug 2008

Journal: Microbiology (Reading, Engl.)

Abstract (Expand)

Proteomic and transcriptomics signatures are powerful tools for visualizing global changes in gene expression in bacterial cells after exposure to stress, starvation or toxic compounds. Based on the ...

Authors: Michael Hecker, Antelmann Haike,Zuber Peter

Date Published: 20th Feb 2008

Journal: Not specified

Abstract (Expand)

The effect of osmotic stress on the intracellular diffusion of proteins in Escherichia coli was studied, using a pulsed version of fluorescence recovery after photo-bleaching, pulsed-FRAP. This method ...

Authors: Bert Poolman, van den Bogaart Geert,Hermans Nicolaas,Krasnikov Victor

Date Published: 28th Apr 2007

Journal: Mol. Microbiol.


Not specified

Author: Crouch Thomas H.,Klee Claude B.

Date Published: 1st Aug 1980

Journal: Biochemistry

Abstract (Expand)

bioRxiv preprint 2017 Plants respond to seasonal cues such as the photoperiod, to adapt to current conditions and to prepare for environmental changes in the season to come. To assess photoperiodic ...

Authors: Daniel Seaton, Andrew Millar, Graf Alexander,Baerenfaller Katja,Stitt Mark,Gruissem Wilhelm

Date Published: No date defined

Journal: Not specified

Abstract (Expand)

Plants use the circadian clock to sense photoperiod length. Seasonal responses like flowering are triggered at a critical photoperiod when a light-sensitive clock output coincides with light or darkness. ...

Author: Flis A.,Sulpice R.,Seaton D. D.,Ivakov A. A.,Liput M.,Abel C.,Millar A. J.,Stitt M.

Date Published: No date defined

Journal: Plant Cell Environ

Abstract (Expand)

Protein synthesis and degradation determine the cellular levels of proteins, and their control hence enables organisms to respond to environmental change. Experimentally, these are little known proteome ...

Author: Martin S. F.,Munagapati V. S.,Salvo-Chirnside E.,Kerr L. E.,Le Bihan T.

Date Published: No date defined

Journal: J Proteome Res

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