Abstract (Expand)

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and is increasing in prevalence. The pathomechanisms, however, are poorly understood. This study ...

Authors: Madlen Matz-Soja, Christiane Rennert, Schönefeld Kristin,Aleithe Susanne,Boettger Jan,Schmidt-Heck Wolfgang,Weiss Thomas S,Hovhannisyan Amalya,Zellmer Sebastian,Klöting Nora,Schulz Angela,Kratzsch Jürgen,Guthke Reinhardt,Gebhardt Rolf

Date Published: 17th May 2016

Journal: Not specified


Not specified

Authors: Dawie Van Niekerk, Jacky Snoep, Gustavsson Anna-Karin,Adiels Caroline B.,Goksör Mattias

Date Published: 3rd Jan 2014

Journal: Not specified

Abstract (Expand)

Dynamic models of metabolism can be useful in identifying potential drug targets, especially in unicellular organisms. A model of glycolysis in the causative agent of human African trypanosomiasis, ...

Authors: Eduard Kerkhoven, Fiona Achcar, Rainer Breitling, Barbara Bakker, Mike Barrett, Alibu V. P.,Burchmore R. J.,Gilbert I. H.,Trybilo M.,Driessen N. N.,Gilbert D.

Date Published: 5th Dec 2013

Journal: PLoS Comput Biol

Abstract (Expand)

In Bacillus subtilis and its relatives carbon catabolite control, a mechanism enabling to reach maximal efficiency of carbon and energy sources metabolism, is achieved by the global regulator CcpA ...

Authors: Bogumila Marciniak, Gerald Seidel, Wolfgang Hillen, Oscar Kuipers, Pabijaniak Monika,de Jong Anne,Dűhring Robert

Date Published: 17th Aug 2012

Journal: BMC Genomics

Abstract (Expand)

The origin of translation and the genetic code is one of the major mysteries of evolution. The advantage of templated protein synthesis could have been achieved only when the translation apparatus had ...

Authors: None

Date Published: 28th Apr 2012

Journal: J. Mol. Evol.

Abstract (Expand)

Appropriate stimulus perception, signal processing and transduction ensure optimal adaptation of bacteria to environmental challenges. In the Gram-positive model bacterium Bacillus subtilis signalling ...

Authors: None

Date Published: 1st Jul 2010

Journal: Not specified

Abstract (Expand)

In response to limiting nutrient sources and cell density signals, Bacillus subtilis can differentiate and form highly resistant endospores. Initiation of spore development is governed by the master ...

Authors: None

Date Published: 12th Feb 2010

Journal: J. Bacteriol.

Abstract (Expand)

We investigate design principles of linear multi-stage phosphorylation cascades by using quantitative measures for signaling time, signal duration and signal amplitude. We compare alternative pathway ...

Authors: Thomas Millat, Olaf Wolkenhauer, Frey Simone,Hohmann Stefan

Date Published: 6th Sep 2007

Journal: J. Theor. Biol.

Abstract (Expand)

It is a long-standing enigma how glycogen storage disease (GSD) type I patients retain a limited capacity for endogenous glucose production despite the loss of glucose-6-phosphatase activity. Insight ...

Authors: Bert Groen, Hijmans B. S.,Boss A.,van Dijk T. H.,Soty M.,Wolters H.,Mutel E.,Derks T. G. J.,Mithieux G.,Heerschap A.,Reijngoud D. J.,Rajas F.,Oosterveer M. H.

Date Published: No date defined

Journal: Hepatology

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