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- Olaf Wolkenhauer
SEEK ID: https://fairdomhub.org/people/10
Location:
Germany
Expertise: dynamics of biological networks, Data analysis Mathematical modelling Bioinformatics Systems biology, Dynamics and Control of Biological Networks
Tools: Computational and theoretical biology, ODE, Matlab, Mathematica, stimulus response experiments, differential algebraic equations, quantitative western blot analyses, quantitative western blot analysis, Stochastic models
ORCID: Not specified
Related items
The project addresses the generation and establishment of programmed pacemaker cells for an in vitro drug testing possibility to perform predictive tests. This may lead to an improved treatment of cardiac arrhythmias or an accurate identification of potential drug molecules at a very early stage of development. Important benefits will arise in verifying the safety of a wide variety of medicines while reducing animal testing. For more information you may visit our project website at
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Programme: Independent Projects
Public web page: https://irhythmics.med.uni-rostock.de/
Organisms: Homo sapiens, Mus musculus
Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.
Programme: Disease Maps
Public web page: http://doi.org/10.17881/covid19-disease-map
The project "INtegrative COllaborative modeling in systems MEdicine" aims at connecting different heterogenous datasets and individual models within systems medicine.
Programme: e:med
Public web page: Not specified
Organisms: Homo sapiens
Bioprocesses for the optimized, integrated production of butyl esters from sustainable resources (BESTER)
Industrial Biotechnology is a key enabling technology to produce a plethora of different bio-based products from sustainable resources and a driver for developing the bio-based economy in Europe. Systems biology and Synthetic biology are recent additions to the biotechnology toolbox that in interplay with bioprocess and chemical process technology can help developing competitive industrial
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Programme: Era CoBioTech
Public web page: https://www.cobiotech.eu/call-information
Organisms: Clostridia Sp.
There is an urgent need for novel antibiotics to fight life-threatening infections and to counteract the increasing problem of propagating antibiotic resistance. Recently, new molecular genetic and biochemical tools have provided insight into the enormous unexploited genetic pool of environmental microbial biodiversity for new antibiotic compounds. New tools for more efficiently lifting this hidden treasure are needed to strengthen competitiveness of European industry, as well as for a cost-saving
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Programme: ERASysAPP
Public web page: https://www.erasysapp.eu/calls/2nd-call/systeract
Organisms: Streptomyces coelicolor
Aim of HUMET Startup Project is to make an inventory of expertise, research goals, resources etc. of the HUMET Coaliytion of the Willing.
Programme: HUMET
Public web page: Not specified
Organisms: Homo sapiens
BaCell-SysMO 2
Modelling carbon core metabolism in Bacillus subtilis – Exploring the contribution of protein complexes in core carbon and nitrogen metabolism.
Bacillus subtilis is a prime model organism for systems biology approaches because it is one of the most advanced models for functional genomics. Furthermore, comprehensive information on cell and molecular biology, physiology and genetics is available and the European Bacillus community (BACELL) has a well-established reputation for applying
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Programme: SysMO
Public web page: http://www.sysmo.net/index.php?index=53
Organisms: Bacillus subtilis
Systems Biology of Clostridium acetobutylicum - a possible answer to dwindling crude oil reserves
Programme: SysMO
Public web page: http://www.sysmo.net/index.php?index=54
Organisms: Clostridium acetobutylicum
This model assumes a phenotypic switch between an acid- and solvent-forming population caused by the changing pH levels. The two phenotypes differ in their transcriptomic, proteomic, and ,thus, their metabolomic profile. Because the growth rates of these phenotypes depends on the extracellular pH, the initiation of the pH-shift results in a significant decline of the acidogenic population. Simultaneously, the solvent-forming population rises and establishes an new steady state.
The model is build
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Creators: Thomas Millat, Graeme Thorn, Olaf Wolkenhauer, John King
Submitter: Thomas Millat
Model type: Ordinary differential equations (ODE)
Model format: Matlab package
Environment: Matlab
Organism: Clostridium acetobutylicum
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Abstract (Expand)
Authors: Martin Scharm, Olaf Wolkenhauer, Mahdi Jalili, Ali Salehzadeh-Yazdi
Date Published: 31st Jan 2020
Publication Type: Journal
DOI: 10.1093/bioinformatics/btaa068
Citation: Bioinformatics
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Authors: Maxwell Lewis Neal, Matthias König, David Nickerson, Göksel Mısırlı, Reza Kalbasi, Andreas Dräger, Koray Atalag, Vijayalakshmi Chelliah, Michael T Cooling, Daniel L Cook, Sharon Crook, Miguel de Alba, Samuel H Friedman, Alan Garny, John H Gennari, Padraig Gleeson, Martin Golebiewski, Michael Hucka, Nick Juty, Chris Myers, Brett G Olivier, Herbert M Sauro, Martin Scharm, Jacky L Snoep, Vasundra Touré, Anil Wipat, Olaf Wolkenhauer, Dagmar Waltemath
Date Published: 1st Mar 2019
Publication Type: Journal
DOI: 10.1093/bib/bby087
Citation: Briefings in Bioinformatics 20(2):540-550
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Date Published: 3rd May 2013
Publication Type: Not specified
PubMed ID: 23640360
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Date Published: 1st Feb 2013
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Authors: , , Jon Marles-Wright, ,
Date Published: 2013
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Authors: , , , , Georg Homuth, ,
Date Published: 2012
Publication Type: Not specified
DOI: 10.1039/C2MB25031D
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Authors: Simone Frey, Kristin Sott, Maria Smedh, , Peter Dahl, , Mattias Goksör
Date Published: 2011
Publication Type: Not specified
DOI: 10.1039/c005305h
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Date Published: 2011
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Date Published: 11th Nov 2010
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PubMed ID: 21063964
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Date Published: 1st Jul 2010
Publication Type: Not specified
DOI: 10.1111/j.1365-2958.2010.07283.x
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Authors: S. Nikolov, X. Lai, , , J. Vera
Date Published: 2010
Publication Type: Not specified
DOI: 10.1080/00207720903147746
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Authors: , Jan-Hendrik S. Hofmeyr
Date Published: 1st May 2008
Publication Type: Not specified
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Authors: Julio Vera, , Walter Kolch,
Date Published: 2008
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Authors: Simone Frey, , Stefan Hohmann,
Date Published: 6th Sep 2007
Publication Type: Not specified
PubMed ID: 18573504
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Authors: , Sree N Sreenath, Radina P Soebiyanto, Jayant Avva, Kwang-Hyun Cho,
Date Published: 17th Jan 2007
Publication Type: Not specified
PubMed ID: 18474306
Citation:
Written by Martin Scharm (University of Rostock), Ron Henkel (University of Rostock), Dagmar Waltemath (University of Rostock), Olaf Wolkenhauer (University of Rostock, Stellenbosch University), and presented by Martin Scharm (University of Rostock) as part of the Reproducible and Citable Data and Models Workshop in Warnemünde, Germany. September 14th - 16th 2015.
Creators: Natalie Stanford, Dagmar Waltemath, Olaf Wolkenhauer, Ron Henkel, Martin Scharm (University of Rostock)
Submitter: Natalie Stanford