Model of the pH-induced metabolic shift in phosphate-limited continuous cultures of C. acetobutylicum assuming a phenotypic switch

Version 1

This model assumes a phenotypic switch between an acid- and solvent-forming population caused by the changing pH levels. The two phenotypes differ in their transcriptomic, proteomic, and ,thus, their metabolomic profile. Because the growth rates of these phenotypes depends on the extracellular pH, the initiation of the pH-shift results in a significant decline of the acidogenic population. Simultaneously, the solvent-forming population rises and establishes an new steady state.

The model is build in Matlab and consists of several functions which define the model, parameters, initial values, and graphical output. Furthermore, the used data are joint using the parameters for the decline of the pH. The population dynamics is estimated from optical density data. The latter two functions are available as independent files.

This model refines our previous model published by Haus et al., BMC Syst. Biol. 5,10 (2011)