Désireé Krausse

About Désireé Krausse:

I`m interested to investigate the Influence of the accumulation of reduction equivalents on solvent production

SEEK ID: https://fairdomhub.org/people/143

Location:  Germany

Expertise: Microbiology, Molecular Biology

Tools: Molecular Biology, northern blot analysis, Molecular biology techniques (RNA/DNA/Protein), qRT-PCR

ORCID: Not specified

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Project positions

COSMIC (University of Goettingen)

Related items

SysMO

SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".

The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.

Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...

Projects: BaCell-SysMO, COSMIC, SUMO, KOSMOBAC, SysMO-LAB, PSYSMO, SCaRAB, MOSES, TRANSLUCENT, STREAM, SulfoSys, SysMO DB, SysMO Funders, SilicoTryp, Noisy-Strep

Web page: http://sysmo.net/

COSMIC

Systems Biology of Clostridium acetobutylicum - a possible answer to dwindling crude oil reserves

Programme: SysMO

Public web page: http://www.sysmo.net/index.php?index=54

University of Goettingen

Country:  Germany

City: Göttingen

Web page: http://www.uni-goettingen.de/

Genome-wide gene expression analysis of the switch between acidogenesis and solventogenesis in continuous cultures of Clostridium acetobutylicum
COSMIC

Abstract (Expand)

Clostridium acetobutylicum is able to switch from acidogenic growth to solventogenic growth. We used phosphate-limited continuous cultures that established acidogenic growth at pH 5.8 and solventogenic … growth at pH 4.5. These cultures allowed a detailed transcriptomic study of the switch from acidogenesis to solventogenesis that is not superimposed by sporulation and other growth phase-dependent parameters. These experiments led to new insights into the physiological role of several genes involved in solvent formation. The adc gene for acetone decarboxylase is upregulated well before the rest of the sol locus during the switch, and pyruvate decarboxylase is induced exclusively for the period of this switch. The aldehyde-alcohol dehydrogenase gene adhE1 located in the sol operon is regulated antagonistically to the paralog adhE2 that is expressed during acidogenic conditions. A similar antagonistic pattern can be seen with the two paralogs of thiolase genes, thlA and thlB. Interestingly, the genes coding for the putative cellulosome in C. acetobutylicum are exclusively transcribed throughout solventogenic growth. The genes for stress response are only induced during the shift but not in the course of solventogenesis when butanol is present in the culture. Finally, the data clearly indicate that solventogenesis is independent from sporulation.

Authors: Christina Grimmler, , , , , , Wolfgang Liebl,

Date Published: 6th Jan 2011

Publication Type: Not specified

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