Complete original MRI data. Bruker format but human readable link names as exam folder, so instead of 2/ the folder is named E002_Anatomy_Light_T2_E2/ derived from the display name.

Complete original MRI data for POD1. Bruker format but human readable link names as exam folder, so instead of 2/ the folder is named E002_Anatomy_Light_T2_E2/ derived from the display name.

Complete original MRI data for POD2. Bruker format but human readable link names as exam folder, so instead of 2/ the folder is named E002_Anatomy_Light_T2_E2/ derived from the display name.

Complete original MRI data for POD3. Bruker format but human readable link names as exam folder, so instead of 2/ the folder is named E002_Anatomy_Light_T2_E2/ derived from the display name.

Complete original MRI data for POD5. Bruker format but human readable link names as exam folder, so instead of 2/ the folder is named E002_Anatomy_Light_T2_E2/ derived from the display name.

The animals undergoing 60% PVL surgery. Surgeries were all performed in room E040a, WKFZ in the S1 area "Kleintier MRT". Post surgery holding was in room E040c directly next door and the final MRI in room E040a and room E040b.

All surgeries were performed by the same surgeon, Wei Weiwei from Prof. Dahmens group (P2).

The Control group underwent no surgery whatsoever (no sham). For the 4 groups POD1, 2, 3 and 5 MRI was performed on the respective day after surgery.

Perfusion Analysis of Control group

The MRI Perfusion technique is FAIR, so three maps were calulated:

Selective Inversion T1 Map Global inversion T1 map Perfusion Map (ml/min/100g)

This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.

The** original Perfusion Map from the Bruker scanner** are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder pdata/ 1/ ...

PRESS based fat quantification

Fat quantification of 5 liver lobes (RML, LML, LLL, RL, CL) During the MRI sesssion at least one PRESS voxel was placed in each of those liver lobes to acquire PRESS data for later fat analysis. Acquisitions were without water suppression, so the fat peaks are relatively small.

The quantification was performed using lcmodel. The original MRI data are part of the MRI session assays (data files uploaded). Here you can find the additional analysis and the output of ...

Perfusion Analysis of Control group

The MRI Perfusion technique is FAIR, so three maps were calulated:

Selective Inversion T1 Map Global inversion T1 map Perfusion Map (ml/min/100g)

This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.

The** original Perfusion Map from the Bruker scanner** are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder pdata/ 1/ ...

Perfusion Analysis of Control group

The MRI Perfusion technique is FAIR, so three maps were calulated:

Selective Inversion T1 Map Global inversion T1 map Perfusion Map (ml/min/100g)

This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.

The** original Perfusion Map from the Bruker scanner** are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder pdata/ 1/ ...

Perfusion Analysis of Control group

The MRI Perfusion technique is FAIR, so three maps were calulated:

Selective Inversion T1 Map Global inversion T1 map Perfusion Map (ml/min/100g)

This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.

The** original Perfusion Map from the Bruker scanner** are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder pdata/ 1/ ...

Perfusion Analysis of Control group

The MRI Perfusion technique is FAIR, so three maps were calulated:

• Selective Inversion T1 Map
• Global inversion T1 map
• Perfusion Map (ml/min/100g)

This was performed once using the Paravision 6.0.1 Macro for Perfusion Evaluation and by using an in house matlab script.

The original Perfusion Map from the Bruker scanner are allready part of the original MRI data. You can find these in each of the Perfusion Exams in the Bruker reconstrcution folder ...

PPK kinetic data for initial rate experiments and for enzyme incubations are linked and available in an Excel file. In addition a model file is available as Mathematica notebook for the parameterization of a rate equation for the enzyme, and for simulation of the enzyme incubations.

You will find the following here:

Data summary for all assays in the study

Graphpad Prism file for all figures + analyses

Cell line: Human aortic smooth muscel cells (Thermo Fisher Scientific, C-007-5C, LOT: 2164581)

Technical replicates: n=4 per condition

Conditions: C3 = TGFB1-treated SMCs C4 = PDGF-BB/IL1B-treated SMCs

Cell line: Human aortic smooth muscel cells (Thermo Fisher Scientific, C-007-5C, LOT: 2164581)

Technical replicates: n=4 per condition

Conditions: C3 = TGFB1-treated SMCs C4 = PDGF-BB/IL1B-treated SMCs