Studies

133 Studies visible to you, out of a total of 325
No description specified

Person responsible: Dawie Van Niekerk

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No description specified

Person responsible: Dawie Van Niekerk

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No description specified

Person responsible: Dawie Van Niekerk

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No description specified

Person responsible: Dawie Van Niekerk

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No description specified

Person responsible: Dawie Van Niekerk

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No description specified

Person responsible: Dawie Van Niekerk

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No description specified

Person responsible: Jacky Snoep

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Here is a collection of examples of possibilities for API communication in R

Person responsible: Andrej Blejec

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No description specified

Person responsible: Maja Rey

Snapshots: Snapshot 1

Data analysis and modelling scripts and results for the Seaton et al. 2017 study, from Daniel Seaton.

Person responsible: Andrew Millar

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Experimental data reported in the Seaton et al. 2017 study; data processing by Alex Graf. Part of the EU FP7 TiMet project.

Person responsible: Andrew Millar

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Literature data and associated scripts analysed in the Seaton et al. 2017 study; data processing by Daniel Seaton.

Literature data used in the Seaton et al. 2017 study; data processing by Daniel Seaton.

This stores:
Processed data files
Links to raw data files
Links to repositories containing applied workflows

Person responsible: Malte Herold

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s-core/ s-core+ network peeling is a methodology to identify cores of weighted complex networks.

PGK-GAPDH reactions were studied in vitro at 30 and 70 using yeast or Sso enzymes

SED-ML:
https://jjj.bio.vu.nl/models/experiments/kouril2017_fig4b/simulate
https://jjj.bio.vu.nl/models/experiments/kouril2017_fig4c/simulate

Person responsible: Theresa Kouril

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PGK reaction at 30 C. Yeast PGK was incubated at 30 C, in the presence or absence of the ATP recycling system, and the conversion of 3 PG to BPG was followed.
SED-ML simulations
Fig. 1A: https://jjj.bio.vu.nl/models/experiments/kouril2017_fig1a/simulate

Person responsible: Jacky Snoep

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PGK reaction at 70C. Sulfolobus solfataricus PGK was incubated at 70C in presence and absence of an ATP recycling system.
Changes in metabolite concentrations was followed via 31P NMR or enzymatic analyses.

SED-ML:
https://jjj.bio.vu.nl/models/experiments/kouril2017_fig3b/simulate
https://jjj.bio.vu.nl/models/experiments/kouril2017_fig3c/simulate
https://jjj.bio.vu.nl/models/experiments/kouril2017_fig3d/simulate

Person responsible: Theresa Kouril

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BPG produced with yeast PGK was incubated at 70 C,upon which BPG rapidly dephosphorylates to 3PG.
SED-ML:
https://jjj.bio.vu.nl/models/experiments/kouril2017_fig2b/simulate

Person responsible: Jacky Snoep

Snapshots: No snapshots

After the removal of the extracellular antibiotic, efflux and inhibition dynamics combine to delay the synthesis of ribosomes in a concentration-dependent manner (panel ii). Colors indicate increasing antibiotic concentration, as shown in panel ii.

SED-ML simulation
https://jjj.bio.vu.nl/models/experiments/srimani2017_fig2cii/simulate

Predictions made using the core model for combinatorial perturbations to the model simulating combined effects from OE, KO mutants, perturbations and time series concentrations.

Person responsible: Niels Zondervan

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Contains copy number per locus tag at different times of Growth between 0.25h and 96 hours.
M. pneumoniae was grown in Batch, cells attached to the bottom of the flask (single cell layer), non stirred, non aerated.

Person responsible: Niels Zondervan

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Personalized liver function tests: A Multiscale Computational Model Predicts Individual Human Liver Function From Single-Cell Metabolism

Understanding how liver function arises from the complex interaction of morphology, perfusion, and metabolism from single cells up to the entire organ requires systems-levels computational approaches. We report a multiscale mathematical model of the Human liver comprising the scales from single hepatocytes, over representation of ultra-structure and micro-circulation
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Person responsible: Matthias König

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Computational modeling of human caffeine clearance by the liver.

More information available from
https://github.com/matthiaskoenig/caffeine

Person responsible: Matthias König

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Internal metabolites concentrations for time series data (not pulse experiments) and for mutant OE, KO mutants and perturbations
External metabolite concentrations for time series data (not pulse experiments) and for mutant OE, KO mutants and perturbations
Mutant (OE, KO, perturbation) metabolite measurements

Person responsible: Niels Zondervan

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Growth-factor deprived mCFU-E cells (5x106 cells per condition) and BaF3-EpoR cells (1x107 cells per condition) were stimulated with different Epo doses and absolute concentrations were determined for pEpoR (B), pAKT (C), ppERK (D). The scale for pS6 (E) was estimated in arbitrary units. GTP-Ras (F) and ppERK were determined upon stimulation with indicated, color-coded Epo doses. pEpoR was analyzed by immunoprecipitation followed by immunoblotting, GTP-Ras was analyzed after pulldown using a
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No description specified

Person responsible: Jay Moore

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Genotype: Wildtype (M145E)
Medium: Phosphate-limited (F134)

Experimental study for hands on session

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