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PoLiMeR is funded through the EU Marie Skłodowska-Curie Innovative Training Network (ITN), which drives scientific excellence and innovation. ITNs bring together universities, research institutes, industry and clinical partners from across the world to train researchers to doctorate level.
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational models fed with individual patient data, has the potential to provide the basis for a personalised diagnosis and treatment strategy. The PoLiMeR consortium (Polymers in the Liver: Metabolism and Regulation) has identified the inherited, liver-related diseases of glycogen and lipid metabolism as the ideal starting point for innovative research training in personalised ‘Systems Medicine'.
Programme: This Project is not associated with a Programme
SEEK ID: https://fairdomhub.org/projects/130
Public web page: http://polimer-itn.eu/
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
FAIRDOM PALs: No PALs for this Project
Project created: 6th Dec 2018
Related items
- People (37)
- Institutions (15)
- Investigations (0+4)
- Studies (0+9)
- Assays (1+18)
- Data files (1+6)
- Models (0+2)
- SOPs (0+8)
- Publications (9)
- Presentations (0+59)
- Events (0+13)
- Documents (3+72)
- Samples (0+4)
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Groningen

Roles: PhD Student
Projects: SilicoTryp, Multiscale modelling of state transitions in the host-microbiome-brain network, MESI-STRAT, PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Groningen

I am a Professor in Medical Systems Biology and the University Medical Centre Groningen. The research in my lab is focused on complex regulation of mammalian lipid and carbohydrate metabolism, eventually aiming at network-based therapies. We combine dynamic computer simulations with quantitative metabolomics, 13C fluxomics, proteomics and transcriptome analysis, and in depth biochemical analysis. This allows to predict and understand ‘emergent’ properties, those properties that are counterintuitive
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Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: Mimetas
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Leiden
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: John Innes Centre
Roles: PhD Student
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Bergen
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: John Innes Centre
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Leiden
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Duesseldorf
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: Iceni Diagnostics Ltd
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Leiden
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Leiden
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University Medical Centre Groningen
Projects: SysMO DB, FAIRDOM, ICYSB 2015 - International Practical Course in Systems Biology, ZucAt, SysMO-LAB, Kinetics on the move - Workshop 2016, Example use cases, FAIRDOM user meeting, ErasysApp Funders, EraCoBiotech 2 nd call proposal preparation, Service to URV Tarragona, Spain with respect to their Safety Assessment of Endocrine Disrupting Chemicals model (Active NOW), FAIRDOM & LiSyM & de.NBI Data Structuring Training, MESI-STRAT, INCOME, Multiscale modelling of state transitions in the host-microbiome-brain network, BESTER, TRALAMINOL, Sustainable co-production, INDIE - Biotechnological production of sustainable indole, Extremophiles metabolsim, PoLiMeR - Polymers in the Liver: Metabolism and Regulation, GB-XMap: Assessing the risk of gut-brain cross-diseases Investigating the gut-brain-axis, NAD COMPARTMENTATION, HOTSOLUTE, Stress granules, FAIRDOM Community Workers, GMDS Project Group "FAIRe Dateninfrastrukturen für die Biomedizinische Informatik", Mechanism based modeling viral disease ( COVID-19 ) dynamics in human population, COVID-19 Disease Map, AquaHealth (ERA-BlueBio), LiSyM Core Infrastructure and Management (LiSyM-PD), Early Metabolic Injury (LiSyM-EMI - Pillar I), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Modelling COVID-19 epidemics, SNAPPER: Synergistic Neurotoxicology APP for Environmental Regulation
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH), FAIRDOM User meeting, Norwegian University of Science and Technology

Expertise: Genetics, Molecular Biology, Bioinformatics, Data Management, Transcriptomics, semantics, Curation, Ontology, Data Modelling
Tools: Cell and tissue culture, Databases, Chip-chip, BioMart, Protege, RightField, SEEK
I am a researcher at the Scientific Databases and Visualization Group at Heidelberg Institute for Theoretical Studies (HITS) , one of the developers of SabioRK - System for the Analysis of Biochemical Pathways - Reaction Kinetics (http://sabiork.h-its.org/) . I am working on design and maintenance of the information systems to store, query and analyse systems biology data; definition and implementation of methods for the integration of data from multiple sources. In SySMO-DB project
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Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: Mimetas
Projects: IMOMESIC, HUMET Startup, PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: Chalmers University of Technology
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH)
Roles: Postdoc
Expertise: metabolism, Liver, fatty acid, Metabolic Models
Tools: experimental tools, Modeling
This profile is created to handle PoLiMeR data only - mainly the materials from Anne-Claire M.F. Martines PhD thesis (temporary solution)
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH)

Roles: PhD Student
Expertise: Java, Data analysis
Country: Germany
City: Düsseldorf
Web page: http://www.biologie.hhu.de/institute-und-abteilungen/pflanzengenetik/leitung-institut.html
Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice. Expression profiling by high throughput sequencing
Submitter: PoLiMeR_user Martines_data
Assay type: Transcriptomics
Technology type: Rna-seq
Snapshots: No snapshots
Investigation: 1 hidden item
Study: 1 hidden item
Organisms: No organisms
SOPs: No SOPs
Data files: Transcriptome analysis in medium-chain acyl-CoA...
Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice. During fasting, mitochondrial fatty-acid β-oxidation (mFAO) is essential for the generation of glucose by the liver. Children with a loss-of-function deficiency in the mFAO enzyme medium-chain acyl-Coenzyme A dehydrogenase (MCAD) are at serious risk of life-threatening low blood glucose levels during fasting in combination with intercurrent disease. However,
...
Creators: PoLiMeR_user Martines_data, Terry G.J. Derks, Barbara Bakker, Martines AMF
Submitter: PoLiMeR_user Martines_data
Investigations: 1 hidden item
Studies: 1 hidden item
Abstract (Expand)
Authors: Anne-Claire M. F. Martines, Albert Gerding, Sarah Stolle, Marcel A. Vieira-Lara, Justina C. Wolters, Angelika Jurdzinski, Laura Bongiovanni, Alain de Bruin, Pieter van der Vlies, Gerben van der Vries, Vincent W. Bloks, Terry G. J. Derks, Dirk-Jan Reijngoud, Barbara M. Bakker
Date Published: 1st Dec 2019
Publication Type: Journal
DOI: 10.1038/s41598-019-50758-0
Citation: Sci Rep 9(1)
Abstract (Expand)
Authors: B. S. Hijmans, A. Boss, T. H. van Dijk, M. Soty, H. Wolters, E. Mutel, A. K. Groen, T. G. J. Derks, G. Mithieux, A. Heerschap, D. J. Reijngoud, F. Rajas, M. H. Oosterveer
Date Published: 21st Jul 2017
Publication Type: Journal
PubMed ID: 28727166
Citation: Hepatology. 2017 Dec;66(6):2042-2054. doi: 10.1002/hep.29389. Epub 2017 Oct 30.
Abstract (Expand)
Authors: K. van Eunen, C. M. Volker-Touw, A. Gerding, A. Bleeker, J. C. Wolters, W. J. van Rijt, A. M. Martines, K. E. Niezen-Koning, R. M. Heiner, H. Permentier, A. K. Groen, D. J. Reijngoud, T. G. Derks, B. M. Bakker
Date Published: 7th Dec 2016
Publication Type: Journal
PubMed ID: 27927213
Citation: BMC Biol. 2016 Dec 7;14(1):107. doi: 10.1186/s12915-016-0327-5.
Abstract (Expand)
Authors: P. Dalle Pezze, S. Ruf, A. G. Sonntag, M. Langelaar-Makkinje, P. Hall, A. M. Heberle, P. Razquin Navas, K. van Eunen, R. C. Tolle, J. J. Schwarz, H. Wiese, B. Warscheid, J. Deitersen, B. Stork, E. Fassler, S. Schauble, U. Hahn, P. Horvatovich, D. P. Shanley, K. Thedieck
Date Published: 21st Nov 2016
Publication Type: Journal
PubMed ID: 27869123
Citation: Nat Commun. 2016 Nov 21;7:13254. doi: 10.1038/ncomms13254.
Abstract (Expand)
Authors: J. C. Wolters, J. Ciapaite, K. van Eunen, K. E. Niezen-Koning, A. Matton, R. J. Porte, P. Horvatovich, B. M. Bakker, R. Bischoff, H. P. Permentier
Date Published: 2nd Sep 2016
Publication Type: Journal
PubMed ID: 27447838
Citation: J Proteome Res. 2016 Sep 2;15(9):3204-13. doi: 10.1021/acs.jproteome.6b00419. Epub 2016 Aug 5.
Abstract (Expand)
Authors: vikash bhardwaj, Vikash bhardwaj, Kulbhushan Sharma
Date Published: 5th May 2016
Publication Type: Journal
Citation: Protocol Exchange
Abstract (Expand)
Author: David L. Vaux
Date Published: 1st Dec 2012
Publication Type: Journal
DOI: 10.1038/492180a
Citation: Nature 492(7428):180-181
Abstract (Expand)
Authors: E. M. Maier, S. W. Gersting, K. F. Kemter, J. M. Jank, M. Reindl, D. D. Messing, M. S. Truger, C. P. Sommerhoff, A. C. Muntau
Date Published: 1st May 2009
Publication Type: Journal
PubMed ID: 19224950
Citation: Hum Mol Genet. 2009 May 1;18(9):1612-23. doi: 10.1093/hmg/ddp079. Epub 2009 Feb 18.
Abstract (Expand)
Authors: H. Herrema, T. G. Derks, T. H. van Dijk, V. W. Bloks, A. Gerding, R. Havinga, U. J. Tietge, M. Muller, G. P. Smit, F. Kuipers, D. J. Reijngoud
Date Published: 7th May 2008
Publication Type: Not specified
PubMed ID: 18459129
Citation: Hepatology. 2008 Jun;47(6):1894-904. doi: 10.1002/hep.22284.
Creator: Chilperic Armel Foko Kuate
Submitter: Chilperic Armel Foko Kuate
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
A computational model of lipids synthesis.
Creator: Chilperic Armel Foko Kuate
Submitter: Chilperic Armel Foko Kuate
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Slides for the Python Workshop
Creator: Oliver Ebenhöh
Submitter: Oliver Ebenhöh
Investigations: No Investigations
Studies: No Studies
Assays: No Assays