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PoLiMeR is funded through the EU Marie Skłodowska-Curie Innovative Training Network (ITN), which drives scientific excellence and innovation. ITNs bring together universities, research institutes, industry and clinical partners from across the world to train researchers to doctorate level.
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational models fed with individual patient data, has the potential to provide the basis for a personalised diagnosis and treatment strategy. The PoLiMeR consortium (Polymers in the Liver: Metabolism and Regulation) has identified the inherited, liver-related diseases of glycogen and lipid metabolism as the ideal starting point for innovative research training in personalised ‘Systems Medicine'.
Programme: This Project is not associated with a Programme
SEEK ID: https://fairdomhub.org/projects/130
Public web page: http://polimer-itn.eu/
Organisms: Homo sapiens
FAIRDOM PALs: No PALs for this Project
Project created: 6th Dec 2018
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- People (31)
- Institutions (14)
- Investigations (0+2)
- Studies (0+5)
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- Publications (5)
- Presentations (0+21)
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Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Groningen
Roles: PhD Student
Projects: SilicoTryp, Multiscale modelling of state transitions in the host-microbiome-brain network, MESI-STRAT, PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Groningen

I am a Professor in Medical Systems Biology and the University Medical Centre Groningen. The research in my lab is focused on complex regulation of mammalian lipid and carbohydrate metabolism, eventually aiming at network-based therapies. We combine dynamic computer simulations with quantitative metabolomics, 13C fluxomics, proteomics and transcriptome analysis, and in depth biochemical analysis. This allows to predict and understand ‘emergent’ properties, those properties that are counterintuitive
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Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: Mimetas
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Leiden
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Duesseldorf
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: John Innes Centre
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: John Innes Centre
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Leiden
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Duesseldorf
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: Iceni Diagnostics Ltd
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Leiden
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Leiden
Projects: SysMO DB, FAIRDOM, ICYSB 2015 - International Practical Course in Systems Biology, ZucAt, SysMO-LAB, Kinetics on the move - Workshop 2016, Example use cases, FAIRDOM user meeting, ErasysApp Funders, EraCoBiotech 2 nd call proposal preparation, Service to URV Tarragona, Spain with respect to their Safety Assessment of Endocrine Disrupting Chemicals model (Active NOW), FAIRDOM & LiSyM & de.NBI Data Structuring Training, MESI-STRAT, INCOME, Multiscale modelling of state transitions in the host-microbiome-brain network, BESTER, TRALAMINOL, Sustainable co-production, INDIE - Biotechnological production of sustainable indole, Extremophiles metabolsim, PoLiMeR - Polymers in the Liver: Metabolism and Regulation, GB-XMap: Assessing the risk of gut-brain cross-diseases Investigating the gut-brain-axis, NAD COMPARTMENTATION, HOTSOLUTE, Stress granules, FAIRDOM Community Workers, GMDS Project Group "FAIRe Dateninfrastrukturen für die Biomedizinische Informatik"
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH), FAIRDOM User meeting, Norwegian University of Science and Technology

Expertise: semantics, data modelling, ontology, curation, Transcriptomics, Data Management, Bioinformatics, Molecular Biology, Genetics
Tools: RightField, Protege, seek, BioMart, Chip-chip, Databases, Cell and tissue culture
I am a researcher at the Scientific Databases and Visualization Group at Heidelberg Institute for Theoretical Studies (HITS) , one of the developers of SabioRK - System for the Analysis of Biochemical Pathways - Reaction Kinetics (http://sabiork.h-its.org/) . I am working on design and maintenance of the information systems to store, query and analyse systems biology data; definition and implementation of methods for the integration of data from multiple sources. In SySMO-DB project
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Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: Mimetas
Projects: IMOMESIC, HUMET Startup, PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: Chalmers University of Technology
Projects: SysMO DB, FAIRDOM, ICYSB 2015 - International Practical Course in Systems Biology, de.NBI-SysBio, Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), Early Metabolic Injury (LiSyM-EMI - Pillar I), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), LiSyM Core Infrastructure and Management (LiSyM-PD), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Kinetics on the move - Workshop 2016, Example use cases, SBEpo - Systems Biology of Erythropoietin, FAIRDOM & LiSyM & de.NBI Data Structuring Training, MESI-STRAT, INCOME, EnzymeML, PoLiMeR - Polymers in the Liver: Metabolism and Regulation, MS_DILI, GMDS Project Group "FAIRe Dateninfrastrukturen für die Biomedizinische Informatik", COMBINE Multicellular Modelling
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH)

I am group leader of the SDBV (Scientific Databases and Visualisation) group at the HITS gGmbH, the Heidelberg Institute for Theoretical Studies.
I am interested in finding data. Starting with my master's thesis I have always worked on how to store data in a way that you can find it, and how to make sense out of data that has been stored.
Within FAIRDOM I find interesting to help people to store their data in a way that they make sense even after years.
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Freiburg
Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University Medical Centre Groningen
Country: Germany
City: Düsseldorf
Web page: http://www.biologie.hhu.de/institute-und-abteilungen/pflanzengenetik/leitung-institut.html
Abstract (Expand)
Authors: J. C. Wolters, J. Ciapaite, K. van Eunen, K. E. Niezen-Koning, A. Matton, R. J. Porte, P. Horvatovich, Barbara Bakker, R. Bischoff, H. P. Permentier
Date Published: No date defined
Journal: J Proteome Res
PubMed ID: 27447838
Citation: J Proteome Res. 2016 Sep 2;15(9):3204-13. doi: 10.1021/acs.jproteome.6b00419. Epub 2016 Aug 5.
Abstract (Expand)
Authors: P. Dalle Pezze, S. Ruf, A. G. Sonntag, M. Langelaar-Makkinje, P. Hall, A. M. Heberle, Patricia Razquin Navas, K. van Eunen, R. C. Tolle, J. J. Schwarz, H. Wiese, B. Warscheid, J. Deitersen, B. Stork, E. Fassler, S. Schauble, U. Hahn, P. Horvatovich, Daryl Shanley, Kathrin Thedieck
Date Published: No date defined
Journal: Nat Commun
PubMed ID: 27869123
Citation: Nat Commun. 2016 Nov 21;7:13254. doi: 10.1038/ncomms13254.
Abstract (Expand)
Authors: B. S. Hijmans, A. Boss, T. H. van Dijk, M. Soty, H. Wolters, E. Mutel, Bert Groen, T. G. J. Derks, G. Mithieux, A. Heerschap, D. J. Reijngoud, F. Rajas, M. H. Oosterveer
Date Published: No date defined
Journal: Hepatology
PubMed ID: 28727166
Citation: Hepatology. 2017 Dec;66(6):2042-2054. doi: 10.1002/hep.29389. Epub 2017 Oct 30.
Abstract (Expand)
Authors: vikash bhardwaj, Vikash bhardwaj, Olga Krebs
Date Published: 5th May 2016
Journal: Protocol Exchange
Citation: Protocol Exchange
Abstract
Author: David L. Vaux
Date Published: 1st Dec 2012
Journal: Nature
DOI: 10.1038/492180a
Citation: Nature 492(7428) : 180
Slides for the Python Workshop
Creator: Oliver Ebenhöh
Contributor: Oliver Ebenhöh
Investigations: No Investigations
Studies: No Studies
Assays: No Assays