Finding new edges: systems approaches to MTOR signaling.

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Abstract:

Cells have evolved highly intertwined kinase networks to finely tune cellular homeostasis to the environment. The network converging on the mechanistic target of rapamycin (MTOR) kinase constitutes a central hub that integrates metabolic signals and adapts cellular metabolism and functions to nutritional changes and stress. Feedforward and feedback loops, crosstalks and a plethora of modulators finely balance MTOR-driven anabolic and catabolic processes. This complexity renders it difficult - if not impossible - to intuitively decipher signaling dynamics and network topology. Over the last two decades, systems approaches have emerged as powerful tools to simulate signaling network dynamics and responses. In this review, we discuss the contribution of systems studies to the discovery of novel edges and modulators in the MTOR network in healthy cells and in disease.

SEEK ID: https://fairdomhub.org/publications/685

PubMed ID: 33544134

Projects: MESI-STRAT, MESI-STRAT Review, PoLiMeR - Polymers in the Liver: Metabolism and Regulation

Publication type: Journal

Journal: Biochem Soc Trans

Citation: Biochem Soc Trans. 2021 Feb 26;49(1):41-54. doi: 10.1042/BST20190730.

Date Published: 26th Feb 2021

Registered Mode: by PubMed ID

Authors: A. M. Heberle, U. Rehbein, M. Rodriguez Peiris, K. Thedieck

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