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Related items
MESI-STRAT: Systems Medicine of Metabolic-Signaling Networks -A New Concept for Breast Cancer Patient Stratification.
Breast cancer is a complex disease with high prevalence in the European Union and world-wide. 75%-80 of the patients have estrogen receptor-positive (ER)-positive tumors and are treated with endocrine therapies. Endocrine therapies, which block ER-driven tumor growth, show high efficacy. Yet, a significant proportion of the patients will eventually relapse with metastatic breast
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Programme: This Project is not associated with a Programme
Public web page: http://www.mesi-strat.eu
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
The project addresses the generation and establishment of programmed pacemaker cells for an in vitro drug testing possibility to perform predictive tests. This may lead to an improved treatment of cardiac arrhythmias or an accurate identification of potential drug molecules at a very early stage of development. Important benefits will arise in verifying the safety of a wide variety of medicines while reducing animal testing. For more information you may visit our project website at
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Programme: Independent Projects
Public web page: https://irhythmics.med.uni-rostock.de/
Organisms: Homo sapiens, Mus musculus
PoLiMeR is funded through the EU Marie Skłodowska-Curie Innovative Training Network (ITN), which drives scientific excellence and innovation. ITNs bring together universities, research institutes, industry and clinical partners from across the world to train researchers to doctorate level.
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease
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Programme: This Project is not associated with a Programme
Public web page: http://polimer-itn.eu/
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
We will contribute to the LiSyM Research Network an open source, freely available and reproducible multiscale model of the human liver from single cell metabolism to whole liver function. The model will be available in existing standards of systems biology, provide standardized interfaces for data integration and be fully annotated to available biological, medical and computational ontologies. All data, models and source code will be shared within the LiSyM Research Network and made available to
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Programme: LiSyM - Systems Medicine of the Liver
Public web page: https://livermetabolism.com
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Multi-level mathematical modeling of erythropoiesis for optimized expansion of erythroid progenitor cells and improved treatment regimes
Programme: e:Bio
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus
This project gathers all biomics projects submitted to biomics.pasteur.fr
Programme: Biomics Platform
Public web page: https://biomics.pasteur.fr/projects
Organisms: Homo sapiens, Escherichia coli K-12, Mus musculus, Plasmodium falciparum
Programme: MS_DILI
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus
Creator: Saptarshi Bej
Submitter: Markus Wolfien
Model type: Not specified
Model format: Not specified
Environment: Not specified
Organism: Mus musculus
Investigations: 1 hidden item
Studies: 1 hidden item
Modelling analyses: sc-SynO: a LoRAS integration to annotate rare-c...
For the spatio-temporal dynamics of bile transport, bile canalicular dilation, mechanical stimulation and transduction of YAP signaling during liver regeneration see the open access publication and its appendix:
Meyer et al. (2020) Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration. Molecular Systems Biology 16:e8985. https://doi.org/10.15252/msb.20198985
The model format is MorpheusML that can readily be loaded and run in the free and open source software
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Creator: Lutz Brusch
Submitter: Lutz Brusch
Model type: Ordinary differential equations (ODE)
Model format: Not specified
Environment: Not specified
Organism: Mus musculus
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Spatio-temporal liver zonation in mouse and human with Wnt-Hh crosstalk and transport are modeled using coupled partial differential equations. The model file is in MorpheusML format and can be opened in the free, open-source multicellular modeling software Morpheus (https://morpheus.gitlab.io). In Morpheus, the model will simulate the time course (movie) of dynamic liver zonation for a 2D cross-section of several liver lobules, showing the patterns of Wnt ligands, intracellular Wnt signaling,
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Creators: Lutz Brusch, Jörn Starruß, Michael Kücken
Submitter: Lutz Brusch
Model type: Partial differential equations (PDE)
Model format: Not specified
Environment: Not specified
Organism: Mus musculus
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Abstract (Expand)
Authors: K. Meyer, H. Morales-Navarrete, S. Seifert, M. Wilsch-Braeuninger, U. Dahmen, E. M. Tanaka, L. Brusch, Y. Kalaidzidis, M. Zerial
Date Published: 25th Feb 2020
Publication Type: Journal
PubMed ID: 32090478
Citation: Mol Syst Biol. 2020 Feb;16(2):e8985. doi: 10.15252/msb.20198985.
Abstract (Expand)
Authors: E. Kolbe, S. Aleithe, C. Rennert, L. Spormann, F. Ott, D. Meierhofer, R. Gajowski, C. Stopel, S. Hoehme, M. Kucken, L. Brusch, M. Seifert, W. von Schoenfels, C. Schafmayer, M. Brosch, U. Hofmann, G. Damm, D. Seehofer, J. Hampe, R. Gebhardt, M. Matz-Soja
Date Published: 24th Dec 2019
Publication Type: Journal
PubMed ID: 31875560
Citation: Cell Rep. 2019 Dec 24;29(13):4553-4567.e7. doi: 10.1016/j.celrep.2019.11.104.
Abstract (Expand)
Authors: V. Becker, M. Schilling, J. Bachmann, U. Baumann, A. Raue, T. Maiwald, J. Timmer, U. Klingmuller
Date Published: 11th Jun 2010
Publication Type: Journal
PubMed ID: 20488988
Citation: Science. 2010 Jun 11;328(5984):1404-8. doi: 10.1126/science.1184913. Epub 2010 May 20.