Details about this organism
Synonyms (1)man
Definitions (0)
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Strain details
Name | Provider name | Provider's strain ID | Genotypes | Phenotypes | Synonym | Comments | Based on |
---|---|---|---|---|---|---|---|
MCF-7 | Opitz lab | MCF-7 | wild-type | wild-type | Not specified | The cells were sent to CHAB from Opitz lab and STR profiled to confirm their identity. Their mutational pattern was analysed by panel DNA sequencing as described in file "MESI-STRATcells.docx". | Not specified |
GM03417 t(14:21) fibroblasts | Coriell Institute | GM03417 | wild-type | wild-type | Not specified | Mosaic t(14,21) translocation | Not specified |
Related items
- Programmes (57)
- Projects (62)
- Assays (17+18)
- Strains (2)
- Models (28+17)
- Publications (10)
- Samples (0+1)
The principal research aim of iPLACENTA is to improve our ability to study, model and visualise the placenta. This will contribute to developing diagnostic tests and therapies for pregnancy complications such as preeclampsia and intrauterine growth restriction (IUGR). Placental defects are thought to be the cause of many major pregnancy complications, such as preeclampsia and intra-uterine growth restriction. Preeclampsia affects between 5 and 8 out of every 100 pregnant women and claims the lives ...
Projects: Molecular characterization and angiogenic properties of extracellular vesicles in healthy and preeclamptic amniotic fluid, Comparative Proteome Profile of Placental Sub-Anatomical Regions, Overexpression of microRNAs miR-25-3p, miR-185-5p and miR-132-3p in Late Onset Fetal Growth Restriction, Validation of Results and Study of the Biochemical Pathways Involved, Comparative Proteome Profile of Placental Sub-anatomical regions - Pilot Study
Web page: https://www.iplacenta.eu/
Projects: Mass spectrometry proteomics for biomarker discovery, TEAD-(YAP) structure, function and inhibition, Thymidylate synthase dimer dissociation
Web page: Not specified
This page is dedicated to the bioinformatics analysis and computational modelling related to Covid-19 disease map pathways.
Projects: Covid-19 Interferon pathway modelling and analysis
Web page: Not specified
We develop macrophage logical models to represent the activation/polarization of this immune cell. Interactions are manually curated with available macrophage literature. The models are mainly built and analyzed in GINsim. But other resources are used to integrate specific pathways or small modules (CasQ software) and to analyze the logical models (CoLoMoTo Notebooks).
Projects: C19DM - Macrophage logical model
Web page: Not specified
We used the Neo4j graph database approach to integrate the content of the COVID-19 Disease Map diagrams to efficiently access, query and manage the content of these diagrams and enable communication with external resources, such as Reactome and Recon, that already provide support via a similar environment.
Projects: C19DM-Neo4j
Web page: Not specified
nfdi4health aims to create the most comprehensive inventory of German epidemiological, public health and clinical trial data to date. It builds a centralised data catalogue with elaborate search functionalities, sophisticated data access management, and a data analysis toolbox, while respecting stringent requirements for privacy concerning personal health data. Standardisation services ensure a high degree of interoperability. Use cases covering prototypical study types and areas of research show ...
Projects: COVID-19 related studies and tools in Germany, nfdi4health - German National Research Data Infrastructure for Personal Health Data
Web page: https://www.nfdi4health.de
nfdi4health aims to create the most comprehensive inventory of German epidemiological, public health and clinical trial data to date. It builds a centralised data catalogue with elaborate search functionalities, sophisticated data access management, and a data analysis toolbox, while respecting stringent requirements for privacy concerning personal health data. Standardisation services ensure a high degree of interoperability. Use cases covering prototypical study types and areas of research show ...
Projects: COVID-19 related studies and tools in Germany, nfdi4health - German National Research Data Infrastructure for Personal Health Data
Web page: https://www.nfdi4health.de
The Disease Maps Project is designed as a large-scale community effort. It is a network of groups that work together in order to better understand disease mechanisms. The project exchanges best practices, share information, develop tools to make it easier for all the involved groups to achieve their goals.
Projects: COVID-19 Disease Map
Web page: https://disease-maps.org
The main objective of the ERANET proposal Systems Biology Applications - ERASysAPP (app = application = translational systems biology) is to promote multidimensional and complementary European systems biology projects, programmes and research initiatives on a number of selected research topics. Inter alia, ERASysAPP will initiate, execute and monitor a number of joint transnational calls on systems biology research projects with a particular focus on applications - or in other words so called ...
Projects: SysVirDrug, SysMilk, SysMetEx, MetApp, IMOMESIC, WineSys, CropClock, SYSTERACT, XyloCut, RootBook, ROBUSTYEAST, LEANPROT, ErasysApp Funders
Web page: https://www.cobiotech.eu/about-cobiotech/erasysapp
The main objective of the ERANET proposal Systems Biology Applications - ERASysAPP (app = application = translational systems biology) is to promote multidimensional and complementary European systems biology projects, programmes and research initiatives on a number of selected research topics. Inter alia, ERASysAPP will initiate, execute and monitor a number of joint transnational calls on systems biology research projects with a particular focus on applications - or in other words so called ...
Projects: SysVirDrug, SysMilk, SysMetEx, MetApp, IMOMESIC, WineSys, CropClock, SYSTERACT, XyloCut, RootBook, ROBUSTYEAST, LEANPROT, ErasysApp Funders
Web page: https://www.cobiotech.eu/about-cobiotech/erasysapp
Projects: Toggle switch, Reduce Complexity (RCO) reconstruction, Model Driven Prime Editing, PULSE 2.0, Plant optogenetics
Projects: Toggle switch, Reduce Complexity (RCO) reconstruction, Model Driven Prime Editing, PULSE 2.0, Plant optogenetics
The RNA Systems Biology Lab Programme compiles the different research projects developed in our lab. The RNA Systems Biology Lab is a collaborative research lab headed by PIs Margarida Gama-Carvalho and Francisco Pinto at the Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, and integrates the BioSystems and Integrative Sciences Institute (BioISI) Gene Expression and Regulation Group, headed by Margarida Gama-Carvalho. Our research brings together computational ...
Projects: CF transcriptome, miRiAD - exploring the role of microRNAs in T cell function and anti-viral defence, ComPASs - Common Pathways in Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), LungCARD - Blood test for clinical therapy guidance of non-small cell lung cancer patients, UnCentre - Unlocking satellite DNA and centromere structure in vertebrate chromosomes, Mapping Disease Modules Overlaps in Biological Networks
Web page: Not specified
The RNA Systems Biology Lab Programme compiles the different research projects developed in our lab. The RNA Systems Biology Lab is a collaborative research lab headed by PIs Margarida Gama-Carvalho and Francisco Pinto at the Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, and integrates the BioSystems and Integrative Sciences Institute (BioISI) Gene Expression and Regulation Group, headed by Margarida Gama-Carvalho. Our research brings together computational ...
Projects: CF transcriptome, miRiAD - exploring the role of microRNAs in T cell function and anti-viral defence, ComPASs - Common Pathways in Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), LungCARD - Blood test for clinical therapy guidance of non-small cell lung cancer patients, UnCentre - Unlocking satellite DNA and centromere structure in vertebrate chromosomes, Mapping Disease Modules Overlaps in Biological Networks
Web page: Not specified
The RNA Systems Biology Lab Programme compiles the different research projects developed in our lab. The RNA Systems Biology Lab is a collaborative research lab headed by PIs Margarida Gama-Carvalho and Francisco Pinto at the Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, and integrates the BioSystems and Integrative Sciences Institute (BioISI) Gene Expression and Regulation Group, headed by Margarida Gama-Carvalho. Our research brings together computational ...
Projects: CF transcriptome, miRiAD - exploring the role of microRNAs in T cell function and anti-viral defence, ComPASs - Common Pathways in Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), LungCARD - Blood test for clinical therapy guidance of non-small cell lung cancer patients, UnCentre - Unlocking satellite DNA and centromere structure in vertebrate chromosomes, Mapping Disease Modules Overlaps in Biological Networks
Web page: Not specified
The RNA Systems Biology Lab Programme compiles the different research projects developed in our lab. The RNA Systems Biology Lab is a collaborative research lab headed by PIs Margarida Gama-Carvalho and Francisco Pinto at the Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, and integrates the BioSystems and Integrative Sciences Institute (BioISI) Gene Expression and Regulation Group, headed by Margarida Gama-Carvalho. Our research brings together computational ...
Projects: CF transcriptome, miRiAD - exploring the role of microRNAs in T cell function and anti-viral defence, ComPASs - Common Pathways in Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), LungCARD - Blood test for clinical therapy guidance of non-small cell lung cancer patients, UnCentre - Unlocking satellite DNA and centromere structure in vertebrate chromosomes, Mapping Disease Modules Overlaps in Biological Networks
Web page: Not specified
The RNA Systems Biology Lab Programme compiles the different research projects developed in our lab. The RNA Systems Biology Lab is a collaborative research lab headed by PIs Margarida Gama-Carvalho and Francisco Pinto at the Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, and integrates the BioSystems and Integrative Sciences Institute (BioISI) Gene Expression and Regulation Group, headed by Margarida Gama-Carvalho. Our research brings together computational ...
Projects: CF transcriptome, miRiAD - exploring the role of microRNAs in T cell function and anti-viral defence, ComPASs - Common Pathways in Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), LungCARD - Blood test for clinical therapy guidance of non-small cell lung cancer patients, UnCentre - Unlocking satellite DNA and centromere structure in vertebrate chromosomes, Mapping Disease Modules Overlaps in Biological Networks
Web page: Not specified
The project addresses the generation and establishment of programmed pacemaker cells for an in vitro drug testing possibility to perform predictive tests. This may lead to an improved treatment of cardiac arrhythmias or an accurate identification of potential drug molecules at a very early stage of development. Important benefits will arise in verifying the safety of a wide variety of medicines while reducing animal testing. For more information you may visit our project website at ...
Programme: Independent Projects
Public web page: https://irhythmics.med.uni-rostock.de/
Organisms: Homo sapiens, Mus musculus
The Integrated Platform for Endocrine Disruptor Risk Assessment (SNAPPER) project will propose solutions based around three core philosophies: Integrated Science: Integration of knowledge from a complete pipeline of systems biology into a holistic yet mechanistic framework that enhances the understanding both of endocrine biology and of adverse effects due to externally induced disruption of the body’s endocrine system. The pipeline includes in vivo, in vitro, and in silico data resulting both ...
Programme: This Project is not associated with a Programme
Public web page: Not specified
Organisms: Homo sapiens
PoLiMeR is funded through the EU Marie Skłodowska-Curie Innovative Training Network (ITN), which drives scientific excellence and innovation. ITNs bring together universities, research institutes, industry and clinical partners from across the world to train researchers to doctorate level.
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease ...
Programme: This Project is not associated with a Programme
Public web page: http://polimer-itn.eu/
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Most biological processes require energy and are tightly regulated. Energy is extracted from food supplies and eventually transformed into ATP, the universal energy carrier of the cell. These pathways consist of many reactions which involve NAD or NADP, small molecules which serve as intermediate energy transmitters. Vitamin B3 is essential for the synthesis of these nucleotides. Interestingly, the key molecules in energy transduction also have important roles in the regulation of all vital ...
Programme: Independent Projects
Public web page: Not specified
Start date: 11th Mar 2018
End date: 28th Feb 2022
Organisms: Homo sapiens
to complete
Organisms: Homo sapiens
nfdi4health aims to create the most comprehensive inventory of German epidemiological, public health and clinical trial data to date. It builds a centralised data catalogue with elaborate search functionalities, sophisticated data access management, and a data analysis toolbox, while respecting stringent requirements for privacy concerning personal health data. Standardisation services ensure a high degree of interoperability. Use cases covering prototypical study types and areas of research show ...
Programme: nfdi4health - German National Research Data Infrastructure for Personal Health Data
Public web page: https://www.nfdi4health.de
Start date: 1st Jul 2020
Organisms: Homo sapiens
Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.
Programme: Disease Maps
Public web page: http://doi.org/10.17881/covid19-disease-map
In the CoVIDD project, we aim at unravelling interactions of viral proteins with the cellular factors and the host pathways involved in SARS-CoV-2 infection by a combination of modern technologies, genomics, proteomics, structural biology, chemoinformatics and drug discovery. To effectively search for drugs that could modify viral replication we need to know what human proteins and viral proteins interact. Thus, a comprehensive virus-host protein interaction network will help us to identify the ...
Programme: This Project is not associated with a Programme
Public web page: Not specified
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Programme: iPlacenta: A European Union Horizon 2020 innovative training network (ITN)
Public web page: Not specified
Organisms: Homo sapiens
MESI-STRAT: Systems Medicine of Metabolic-Signaling Networks -A New Concept for Breast Cancer Patient Stratification. Breast cancer is a complex disease with high prevalence in the European Union and world-wide. 75%-80 of the patients have estrogen receptor-positive (ER)-positive tumors and are treated with endocrine therapies. Endocrine therapies, which block ER-driven tumor growth, show high efficacy. Yet, a significant proportion of the patients will eventually relapse with metastatic breast ...
Programme: This Project is not associated with a Programme
Public web page: http://www.mesi-strat.eu
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
Aim of HUMET Startup Project is to make an inventory of expertise, research goals, resources etc. of the HUMET Coaliytion of the Willing.
Programme: HUMET
Public web page: Not specified
Organisms: Homo sapiens
IMOMESIC - Integrating Modelling of Metabolism and Signalling towards an Application in Liver Cancer
One of the most challenging questions in cancer research is currently the interconnection of metabolism and signalling. An understanding of mechanisms that facilitate the physiological shift towards a proliferative metabolism in cancer cells is considered a major upcoming topic in oncology and is a key activity for future drug development. Due to the complexity of interrelations, a systems biology ...
Programme: ERASysAPP
Public web page: Not specified
Organisms: Homo sapiens
Good data and model management improves the longevity and impact of your interdisciplinary research. FAIRDOM offers software and expertise to support you in better managing your interdisciplinary life-science projects, particularly in systems and synthetic biology. If you have never heard of data and model management, or are curious about it, or you are an expert keen to exchange ideas, our user meeting is the place for you!
At our users meeting you can:
- Learn why data and model management is ...
Programme: FAIRDOM
Public web page: Not specified
Organisms: Homo sapiens
This project bundles information about COVID-19 related studies and tools in Germany. It intends to provide an information hub for the different initiatives, their aims, their processes, standards and study protocols, as well as their available data and metadata. It is initiated by the German National Research Data Infrastructure for Personal Health Data (nfdi4health), a consortium that plans to establish a concept for a federated research data infrastructure for personal health data in Germany. ...
Programme: Cancer drug discovery preclinical research
Public web page: Not specified
Organisms: Homo sapiens
The project "INtegrative COllaborative modeling in systems MEdicine" aims at connecting different heterogenous datasets and individual models within systems medicine.
Programme: e:med
Public web page: Not specified
Organisms: Homo sapiens
Programme: Covid-19 disease map - Bioinformatics analysis and computational modelling
Public web page: Not specified
Start date: 1st May 2020
In this project, we integrate COVID19 Disease Maps curated regulatory information in a macrophage logical model. This allows logical simulations of the effects of acute inflammation caused by the SARS-CoV-2 virus, both in general and in a cell-specific perspective. Moreover, understanding the regulatory network behavior of macrophages following infection opens new ways to test and predict drug and drug combination effects, as a first step towards the development of new treatments.
Organisms: Homo sapiens
Data and experimental methods to support the work in the following paper:
Establishing Consensus Annotation for the Hallmarks of Cancer, 2020, Yi Chen, F.J.Verbeek and K.Wolstencroft, in submission
Programme: Hallmarks of cancer
Public web page: Not specified
Organisms: Homo sapiens
We used the Neo4j graph database approach to integrate the content of the COVID-19 Disease Map diagrams to efficiently access, query and manage the content of these diagrams and enable communication with external resources, such as Reactome and Recon, that already provide support via a similar environment. This work complements the efforts on exploring COVID-19 disease mechanisms within the COVID-19 Disease Map Project.
Programme: C19DM-Neo4j
Public web page: Not specified
Start date: 1st Sep 2020
End date: 31st Dec 2022
Data digitized from publication.
Hetzler1990 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Hetzler1990), PNG (Hetzler1990)
Snapshots: No snapshots
Data digitized from publication.
Magnusson2008 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Magnusson2008), PNG (Magnusson2008)
Snapshots: No snapshots
Data digitized from publication.
Perera2011 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Perera2011), PNG (Perera2011)
Snapshots: No snapshots
Data digitized from publication.
Tanaka2014 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Tanaka2014), PNG (Tanaka2014)
Snapshots: No snapshots
Data digitized from publication.
Blanchard1983a Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Blanchard1983a), PNG (Blanchard1983a)
Snapshots: No snapshots
Data digitized from publication.
Kaplan1997 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Kaplan1997), PNG (Kaplan1997)
Snapshots: No snapshots
Data digitized from publication.
Amchin1999 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Amchin1999), PNG (Amchin1999)
Snapshots: No snapshots
Data digitized from publication.
Haller2002 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Haller2002), PNG (Haller2002)
Snapshots: No snapshots
Data digitized from publication.
Kakuda2014 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Kakuda2014), PNG (Kakuda2014)
Snapshots: No snapshots
Data digitized from publication.
Akinyinka2000 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Akinyinka2000), PNG (Akinyinka2000)
Snapshots: No snapshots
Data digitized from publication.
Healy1991 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Healy1991), PNG (Healy1991)
Snapshots: No snapshots
Data digitized from publication.
Oh2012 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Oh2012), PNG (Oh2012)
Snapshots: No snapshots
Data digitized from publication.
Jeppesen1996 Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Jeppesen1996), PNG (Jeppesen1996)
Snapshots: No snapshots
Data digitized from publication.
Spigset1999a Description
Submitter: Matthias König
Investigation: MM-PLF: Multiscale modeling for personalized li...
Study: PKDB Caffeine Study
Organisms: Homo sapiens
SOPs: No SOPs
Data files: CSV (Spigset1999a), PNG (Spigset1999a)
Snapshots: No snapshots
Submitter: Alexey Kolodkin
Biological problem addressed: Model Analysis Type
Investigation: ROS networks: designs, aging, Parkinson's disea...
Organisms: Homo sapiens
Models: Calibrated comprehensive model of ROS management, Calibrated comprehensive model of ROS managemen..., Detailed model of ROS management
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
Submitter: Arnau Montagud
Biological problem addressed: Gene Regulatory Network
Investigation: PhysiBoSS-COVID: the Boolean modelling of COVID...
Organisms: Homo sapiens
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
Submitter: Arnau Montagud
Biological problem addressed: Gene Regulatory Network
Investigation: PhysiBoSS-COVID: the Boolean modelling of COVID...
Organisms: Homo sapiens
Models: No Models
SOPs: No SOPs
Data files: No Data files
Snapshots: No snapshots
Submitter: Margarida Gama-Carvalho
Provider Name: Coriell Institute
Provider's strain ID: GM03417
Organism: Homo sapiens
Genotypes: wild-type
Phenotypes: wild-type
Comment: Mosaic t(14,21) translocation
Submitter: Pamela Riemer
Provider Name: Opitz lab
Provider's strain ID: MCF-7
Organism: Homo sapiens
Genotypes: wild-type
Phenotypes: wild-type
Comment: The cells were sent to CHAB from Opitz lab and STR profiled to confirm their identity. Their mutational pattern was analysed by panel DNA sequencing as described in file "MESI-STRATcells.docx".
NLRP3 inflammasome activation
Creators: Julia Somers, Gökçe Yağmur Summak, Ebru Kocakaya
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
Thrombotic complications and coagulopathy in COVID-19
Creators: Goar Frischmann, Gisela Fobo, Corinna Montrone
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
Kynurenine synthesis pathway
Creators: Julia Somers, Gökçe Yağmur Summak, Ebru Kocakaya
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
TGF beta signalling
Creator: Francesco Messina
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
The role of the interaction between the SARS-CoV-2 Spike protein and the renin-angiotensin pathway, in particular human ACE2 in pulmonary blood pressure regulation
Creators: Andreas Ruepp, Corinna Montrone, Gisela Fobo, Enrico Glaab
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
The Interferon-lambda (IFNL) map describes the action of the drug candidate IFNL on intra- and intercellular signal transduction under SARS-CoV-2.
Creators: Marius Rameil, Vanessa Nakonecnij, Marta Conti
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
The relation of the interferon 2 pathway and SARS-CoV-2.
Creators: Anna Niarakis, Vidisha Singh, Sara Sadat AGHAMIRI
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
The pathway of heme metabolism under COVID-19, involving Orf3a and Orf9c
Creators: Emek Demir, Julia Somers
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
The impact of SARS-CoV-2 on the apoptosis pathway
Creators: Anna Niarakis, Vidisha Singh, Sara Sadat AGHAMIRI
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
The pathways focused on SARS-CoV infections curated in Reactome. These pathways are work-in-progress.
Creators: Peter D'Eustachio, Marc Gillespie, Robin Haw
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBGN-ML PD
Environment: Not specified
A diagram of Nsp9 interactions.
Creators: Noriko Hiroi, Yusuke Hiki, Takahiro G. Yamada, Akira Funahashi
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
Orf10 of SARS-CoV-2 and its interaction with the Cul2 pathway.
Creators: Jan Hasenauer, Leonard Schmiester, Paul Stapor
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
Pyrimidine deprivation and immune response related to human coronavirus infection
Creators: Zsolt Bocskei, Franck Augé, Anna Niarakis
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
The mechanisms of the Electron Transport Chain under COVID-19, including Nsp7, Nsp8 and Orf9c
Creator: Julia Scheel
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
SARS-CoV-2 impact on the ER stress
Creators: Barbara Brauner, Cristobal Monraz, Inna Kuperstein
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
COVID-19 Causal Networks: The SIGNOR team has curated the causal relationships that, according to available evidence, are likely to be relevant for the COVID-19 pathology. The perturbations caused by viral infection are integrated into the cell networks. Evidence obtained using related human coronaviruses diseases such as SARS and MERS are also mapped to the networks. Most of these are indirect relationships as few mechanistic details are clarified to date. As new evidence will be published, it ...
Creators: Luana Licata, Marta Iannuccelli, University of Rome Tor Vergata, IT
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: Not specified
Environment: Not specified
Metabolic interactions of the SARS-CoV-2 Nsp14 with the human galactose, nicotinate and nicotinamide, and purine metabolism.
Creators: Alina Renz, Andreas Dräger
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
Interactions of the SARS-CoV-2 E protein with human proteins in the context of histone acetylation.
Creator: Francesco Messina
Submitter: Marek Ostaszewski
Model type: Not specified
Model format: Not specified
Environment: Not specified
Set of pathways encompassing the replication cycle of SARS-CoV-2: attachment, entry, translation, transcription, replication, assembly and release.
Creators: Marcio Acencio, Alexander Mazein
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
A diagram of JNK pathway in COVID-19.
Creator: Daniela Börnigen
Submitter: Marek Ostaszewski
Model type: Graphical model
Model format: SBML
Environment: Not specified
Abstract (Expand)
Authors: Mitsuhiro Odaka, Morgan Magnin, Katsumi Inoue
Date Published: 11th Feb 2022
Publication Type: Journal
DOI: 10.21203/rs.3.rs-1300133/v1
Citation: [Preprint]
Abstract (Expand)
Authors: Hans V. Westerhoff, Alexey N. Kolodkin
Date Published: 1st Dec 2020
Publication Type: Journal
DOI: 10.1038/s41540-020-0138-8
Citation: npj Syst Biol Appl 6(1),18
Abstract (Expand)
Authors: A. N Kolodkin, R. P. Sharma, A. M. Colangelo, A. Ignatenko, F. Martorana, D. Jennen, J. J. Briede, N. Brady, M. Barberis, T. D. G. A. Mondeel, M. Papa, V. Kumar, B. Peters, A. Skupin, L. Alberghina, R. Balling, H. V. Westerhoff
Date Published: 26th Oct 2020
Publication Type: Journal
PubMed ID: 33106503
Citation: NPJ Syst Biol Appl. 2020 Oct 26;6(1):34. doi: 10.1038/s41540-020-00150-w.
Abstract
Authors: Michael Getz, Yafei Wang, Gary An, Maansi Asthana, Andrew Becker, Chase Cockrell, Nicholson Collier, Morgan Craig, Courtney L. Davis, James R. Faeder, Ashlee N. Ford Versypt, Tarunendu Mapder, Juliano F. Gianlupi, James A. Glazier, Sara Hamis, Randy Heiland, Thomas Hillen, Dennis Hou, Mohammad Aminul Islam, Adrianne L. Jenner, Furkan Kurtoglu, Caroline I. Larkin, Bing Liu, Fiona Macfarlane, Pablo Maygrundter, Penelope A Morel, Aarthi Narayanan, Jonathan Ozik, Elsje Pienaar, Padmini Rangamani, Ali Sinan Saglam, Jason Edward Shoemaker, Amber M. Smith, Jordan J.A. Weaver, Paul Macklin
Date Published: 5th Apr 2020
Publication Type: Journal
DOI: 10.1101/2020.04.02.019075
Citation: biorxiv;2020.04.02.019075v4,[Preprint]
Abstract (Expand)
Authors: A. Montagud, P. Traynard, L. Martignetti, E. Bonnet, E. Barillot, A. Zinovyev, L. Calzone
Date Published: 19th Jul 2019
Publication Type: Journal
PubMed ID: 29237040
Citation: Brief Bioinform. 2019 Jul 19;20(4):1238-1249. doi: 10.1093/bib/bbx163.
Abstract
Authors: Gaelle Letort, Arnau Montagud, Gautier Stoll, Randy Heiland, Emmanuel Barillot, Paul Macklin, Andrei Zinovyev, Laurence Calzone
Date Published: 1st Apr 2019
Publication Type: Journal
DOI: 10.1093/bioinformatics/bty766
Citation: Bioinformatics 35(7):1188-1196
Abstract (Expand)
Authors: G. Stoll, B. Caron, E. Viara, A. Dugourd, A. Zinovyev, A. Naldi, G. Kroemer, E. Barillot, L. Calzone
Date Published: 15th Jul 2017
Publication Type: Journal
PubMed ID: 28881959
Citation: Bioinformatics. 2017 Jul 15;33(14):2226-2228. doi: 10.1093/bioinformatics/btx123.
Abstract (Expand)
Authors: M. Poenisch, P. Metz, H. Blankenburg, A. Ruggieri, J. Y. Lee, D. Rupp, I. Rebhan, K. Diederich, L. Kaderali, F. S. Domingues, M. Albrecht, V. Lohmann, H. Erfle, R. Bartenschlager
Date Published: 8th Jan 2015
Publication Type: Not specified
PubMed ID: 25569684
Citation: PLoS Pathog. 2015 Jan 8;11(1):e1004573. doi: 10.1371/journal.ppat.1004573. eCollection 2015 Jan.
Abstract (Expand)
Authors: G. Stoll, E. Viara, E. Barillot, L. Calzone
Date Published: 29th Aug 2012
Publication Type: Journal
PubMed ID: 22932419
Citation: BMC Syst Biol. 2012 Aug 29;6:116. doi: 10.1186/1752-0509-6-116.
Abstract (Expand)
Authors: Alexey Kolodkin, Raju Prasad Sharma, Anna Maria Colangelo, Andrew Ignatenko, Francesca Martorana, Danyel Jennen, Jacco J. Briede, Nathan Brady, Matteo Barberis, Thierry D.G.A. Mondeel, Michele Papa, Vikas Kumar, Bernhard Peters, Alexander Skupin, Lilia Alberghina, Rudi Balling, Hans V. Westerhoff
Date Published: No date defined
Publication Type: Not specified
DOI: 10.1101/647776
Citation: Design principles of ROS dynamic networks relevant to precision therapies for age-related diseases 74 : 324