MESI-STRAT: Systems Medicine of Metabolic-Signaling Networks -A New Concept for Breast Cancer Patient Stratification. Breast cancer is a complex disease with high prevalence in the European Union and world-wide. 75%-80 of the patients have estrogen receptor-positive (ER)-positive tumors and are treated with endocrine therapies. Endocrine therapies, which block ER-driven tumor growth, show high efficacy. Yet, a significant proportion of the patients will eventually relapse with metastatic breast cancer, and the recurrence rates remain almost constant for up to 20 years. MESI-STRAT develops metabolite marker panels measurable in biological fluids to enable patient stratification, resistance monitoring and clinical decision-making throughout endocrine therapy. This is a new concept as breast cancer metabolism is poorly explored for diagnostics and therapy. Upon successful validation in preclinical models, the predictive marker panels and related treatments will be jointly investigated by MESI-STRAT’s clinical and industrial partners. The MESI-STRAT consortium explores the interplay of breast cancer metabolism and oncogenic signaling (MEtabolic SIgnaling) by systems medicine approaches. MESI-STRAT develops new models for knowledge-based STRATification of patients into subgroups with different endocrine therapy resistance mechanisms.
Programme: This Project is not associated with a Programme
SEEK ID: https://fairdomhub.org/projects/99
Public web page: http://www.mesi-strat.eu
Organisms: Homo sapiens, Mus musculus, Rattus norvegicus
FAIRDOM PALs: No PALs for this Project
Project created: 26th Feb 2018
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- Investigations (0+8)
- Studies (0+20)
- Assays (0+45)
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- Data files (4+74)
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- Publications (15)
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Projects: MESI-STRAT
Institutions: Medical University Innsbruck
Projects: MESI-STRAT
Institutions: PATH - Patients' Tumor Bank of Hope
Projects: SilicoTryp, Multiscale modelling of state transitions in the host-microbiome-brain network, MESI-STRAT, PoLiMeR - Polymers in the Liver: Metabolism and Regulation
Institutions: University of Groningen

I am a Professor in Medical Systems Biology and the University Medical Centre Groningen. The research in my lab is focused on complex regulation of mammalian lipid and carbohydrate metabolism, eventually aiming at network-based therapies. We combine dynamic computer simulations with quantitative metabolomics, 13C fluxomics, proteomics and transcriptome analysis, and in depth biochemical analysis. This allows to predict and understand ‘emergent’ properties, those properties that are counterintuitive ...
Projects: MESI-STRAT
Institutions: University of Innsbruck
Projects: MESI-STRAT
Institutions: Medical University Innsbruck
Projects: MESI-STRAT
Institutions: University of Newcastle
Projects: MESI-STRAT
Institutions: German Cancer Research Center (DKFZ)
Projects: MESI-STRAT
Institutions: Medical University Innsbruck
Projects: MESI-STRAT
Institutions: PD-Value
Jeroen Elassaiss-Schaap, (jeroen@pd-value.com)
Projects: MESI-STRAT
Institutions: University of Innsbruck
Expertise: Project Management
Projects: MESI-STRAT
Institutions: University of Heidelberg
Projects: MESI-STRAT
Institutions: Charité University Medicine Berlin
Projects: MESI-STRAT
Institutions: University of Bergen
Projects: Stress granules, MESI-STRAT
Institutions: University of Bergen
Expertise: RNA, alternative splicing, Bioinformatics, Genomics
More detailed profile here https://www.uib.no/en/persons/Sushma.Grellscheid
Projects: MESI-STRAT, NAD COMPARTMENTATION, NAD phylogeny
Institutions: The Arctic University of Norway (UiT)
Projects: MESI-STRAT
Institutions: Neuroimmun GmbH
Projects: MESI-STRAT
Institutions: Medical University Innsbruck
Projects: SysMO DB, FAIRDOM, ICYSB 2015 - International Practical Course in Systems Biology, ZucAt, SysMO-LAB, Kinetics on the move - Workshop 2016, Example use cases, FAIRDOM user meeting, ErasysApp Funders, EraCoBiotech 2 nd call proposal preparation, Service to URV Tarragona, Spain with respect to their Safety Assessment of Endocrine Disrupting Chemicals model (Active NOW), FAIRDOM & LiSyM & de.NBI Data Structuring Training, MESI-STRAT, INCOME, Multiscale modelling of state transitions in the host-microbiome-brain network, BESTER, TRALAMINOL, Sustainable co-production, INDIE - Biotechnological production of sustainable indole, Extremophiles metabolsim, PoLiMeR - Polymers in the Liver: Metabolism and Regulation, GB-XMap: Assessing the risk of gut-brain cross-diseases Investigating the gut-brain-axis, NAD COMPARTMENTATION, HOTSOLUTE, Stress granules, FAIRDOM Community Workers, GMDS Project Group "FAIRe Dateninfrastrukturen für die Biomedizinische Informatik", Mechanism based modeling viral disease ( COVID-19 ) dynamics in human population, COVID-19 Disease Map, AquaHealth (ERA-BlueBio), LiSyM Core Infrastructure and Management (LiSyM-PD), Early Metabolic Injury (LiSyM-EMI - Pillar I), Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Modelling COVID-19 epidemics, SNAPPER: Synergistic Neurotoxicology APP for Environmental Regulation, SCyCode The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers, SASKit: Senescence-Associated Systems diagnostics Kit for cancer and stroke, CC-TOP, BioCreative VII
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH), FAIRDOM User meeting, Norwegian University of Science and Technology, University of Rostock

Expertise: Genetics, Molecular Biology, Bioinformatics, Data Management, Transcriptomics, semantics, Curation, Ontology, Data Modelling
Tools: Cell and tissue culture, Databases, Chip-chip, BioMart, Protege, RightField, SEEK
I am a researcher at the Scientific Databases and Visualization Group at Heidelberg Institute for Theoretical Studies (HITS) , one of the developers of SabioRK - System for the Analysis of Biochemical Pathways - Reaction Kinetics (http://sabiork.h-its.org/) . I am working on design and maintenance of the information systems to store, query and analyse systems biology data; definition and implementation of methods for the integration of data from multiple sources. In SySMO-DB project ...
Projects: MESI-STRAT
Institutions: University Medical Centre Groningen
Submitter: Pamela Riemer
Provider Name: Opitz lab
Provider's strain ID: MCF-7
Organism: Homo sapiens
Genotypes: wild-type
Phenotypes: wild-type
Comment: The cells were sent to CHAB from Opitz lab and STR profiled to confirm their identity. Their mutational pattern was analysed by panel DNA sequencing as described in file "MESI-STRATcells.docx".
Global microRNA expression profiling of high-risk ER+ breast cancers from patients receiving adjuvant Tamoxifen mono-therapy: a DBCG study
Creator: Lyng MB, Lænkholm A, Søkilde R, Gravgaard KH, LItman T, Ditzel HJ
Submitter: Olga Krebs
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
GEO Data set GSE9893 : A gene expression signature predicting the recurrence of tamoxifen-treated primary breast cancer.
Creator: Chanrion M, Vincent N, Fontaine H, Salvetat N, Bibeau F, MacGrogan G, Mauriac L, Katsaros D, Molina F, Theillet C, Darbon JM
Submitter: Olga Krebs
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Shared version of Publication "Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25"
Creators: Mathias Ziegler, Ines Heiland, Magnus Monné, Andrey Nikiforov, Gennaro Agrimi, Ferdinando Palmieri
Submitter: Olga Krebs
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
First MESI-STRAT Newsletter June 2019
Creators: Petra Engele, Kathrin Thedieck, Tobias Anzeneder, Janina Leyk
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Standard Operating Procedure for human genomic DNA extraction ( copied from GEO DataSets GSM1375121)
Creators: Olga Krebs, Christiane Opitz
Submitter: Olga Krebs
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Abstract (Expand)
Authors: Jörn Dietze, Alienke van Pijkeren, Anna-Sophia Egger, Mathias Ziegler, Marcel Kwiatkowski, Ines Heiland
Date Published: 1st Dec 2021
Publication Type: Journal
DOI: 10.1007/s00216-021-03732-7
Citation: Anal Bioanal Chem 413(30):7333-7340
Abstract (Expand)
Authors: M. Ziegler, M. Monne, A. Nikiforov, G. Agrimi, I. Heiland, F. Palmieri
Date Published: 14th Jun 2021
Publication Type: Journal
PubMed ID: 34198503
Citation: Biomolecules. 2021 Jun 14;11(6). pii: biom11060880. doi: 10.3390/biom11060880.
Abstract (Expand)
Authors: S. R. Mohapatra, A. Sadik, S. Sharma, G. Poschet, H. M. Gegner, T. V. Lanz, P. Lucarelli, U. Klingmuller, M. Platten, I. Heiland, C. A. Opitz
Date Published: 8th Mar 2021
Publication Type: Journal
PubMed ID: 33679737
Citation: Front Immunol. 2021 Feb 19;12:590532. doi: 10.3389/fimmu.2021.590532. eCollection 2021.
Abstract (Expand)
Authors: Ahmed Sadik, Luis F. Somarribas Patterson, Selcen Öztürk, Soumya R. Mohapatra, Verena Panitz, Philipp F. Secker, Pauline Pfänder, Stefanie Loth, Heba Salem, Mirja Tamara Prentzell, Bianca Berdel, Murat Iskar, Erik Faessler, Friederike Reuter, Isabelle Kirst, Verena Kalter, Kathrin I. Foerster, Evelyn Jäger, Carina Ramallo Guevara, Mansour Sobeh, Thomas Hielscher, Gernot Poschet, Annekathrin Reinhardt, Jessica C. Hassel, Marc Zapatka, Udo Hahn, Andreas von Deimling, Carsten Hopf, Rita Schlichting, Beate I. Escher, Jürgen Burhenne, Walter E. Haefeli, Naveed Ishaque, Alexander Böhme, Sascha Schäuble, Kathrin Thedieck, Saskia Trump, Martina Seiffert, Christiane A. Opitz
Date Published: 1st Sep 2020
Publication Type: Journal
DOI: 10.1016/j.cell.2020.07.038
Citation: Cell 182(5):1252-1270.e34
Abstract (Expand)
Authors: Lukas Metzler, Ulrike Rehbein, Jan-Niklas Schönberg, Thomas Brandstetter, Kathrin Thedieck, Jürgen Rühe
Date Published: 4th Aug 2020
Publication Type: Journal
DOI: 10.1021/acs.analchem.0c00187
Citation: Anal. Chem. 92(15):10283-10290
Abstract (Expand)
Authors: C. A. Opitz, L. F. Somarribas Patterson, S. R. Mohapatra, D. L. Dewi, A. Sadik, M. Platten, S. Trump
Date Published: 11th Dec 2019
Publication Type: Journal
PubMed ID: 31819194
Citation: Br J Cancer. 2020 Jan;122(1):30-44. doi: 10.1038/s41416-019-0664-6. Epub 2019 Dec 10.
Abstract (Expand)
Authors: Philipp Zimmer, Martina E. Schmidt, Mirja Tamara Prentzell, Bianca Berdel, Joachim Wiskemann, Karl Heinz Kellner, Jürgen Debus, Cornelia Ulrich, Christiane A. Opitz, Karen Steindorf
Date Published: 25th Sep 2019
Publication Type: Not specified
Citation: Front. Oncol. 9 : 673
Abstract (Expand)
Authors: M. Bockwoldt, D. Houry, M. Niere, T. I. Gossmann, I. Reinartz, A. Schug, M. Ziegler, I. Heiland
Date Published: 6th Aug 2019
Publication Type: Journal
PubMed ID: 31341085
Citation: Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15957-15966. doi: 10.1073/pnas.1902346116. Epub 2019 Jul 24.
Abstract (Expand)
Authors: Mahdi Shafiee Kamalabad, Alexander Martin Heberle, Kathrin Thedieck, Marco Grzegorczyk
Date Published: 1st Jun 2019
Publication Type: Journal
DOI: 10.1093/bioinformatics/bty917
Citation: Bioinformatics 35(12):2108-2117
Abstract (Expand)
Authors: Michael Platten, Ellen A. A. Nollen, Ute F. Röhrig, Francesca Fallarino, Christiane A. Opitz
Date Published: 1st May 2019
Publication Type: Journal
DOI: 10.1038/s41573-019-0016-5
Citation: Nat Rev Drug Discov 18(5):379-401
Abstract (Expand)
Authors: Alexander Martin Heberle, Patricia Razquin Navas, Miriam Langelaar-Makkinje, Katharina Kasack, Ahmed Sadik, Erik Faessler, Udo Hahn, Philip Marx-Stoelting, Christiane A Opitz, Christine Sers, Ines Heiland, Sascha Schäuble, Kathrin Thedieck
Date Published: 28th Mar 2019
Publication Type: Not specified
Citation: Life Sci. Alliance 2(2) : e201800257
Abstract (Expand)
Authors: H. D. Biesma, P. C. Schouten, M. M. Lacle, J. Sanders, W. Brugman, R. Kerkhoven, I. Mandjes, P. van der Groep, P. J. van Diest, S. C. Linn
Date Published: 11th Sep 2015
Publication Type: Journal
PubMed ID: 26355282
Citation: Genes Chromosomes Cancer. 2015 Dec;54(12):734-44. doi: 10.1002/gcc.22284. Epub 2015 Sep 10.
Abstract (Expand)
Authors: A. K. Stavrum, I. Heiland, S. Schuster, P. Puntervoll, M. Ziegler
Date Published: 29th Nov 2013
Publication Type: Journal
PubMed ID: 24129579
Citation: J Biol Chem. 2013 Nov 29;288(48):34555-66. doi: 10.1074/jbc.M113.474908. Epub 2013 Oct 15.
Abstract (Expand)
Authors: I. Johansson, C. Nilsson, P. Berglund, M. Lauss, M. Ringner, H. Olsson, L. Luts, E. Sim, S. Thorstensson, M. L. Fjallskog, I. Hedenfalk
Date Published: 14th Feb 2012
Publication Type: Journal
PubMed ID: 22333393
Citation: Breast Cancer Res. 2012 Feb 14;14(1):R31. doi: 10.1186/bcr3116.
Abstract (Expand)
Authors: D. L. Dewi, S. R. Mohapatra, S. Blanco Cabanes, I. Adam, L. F. Somarribas Patterson, B. Berdel, M. Kahloon, L. Thurmann, S. Loth, K. Heilmann, D. Weichenhan, O. Mucke, I. Heiland, P. Wimberger, J. D. Kuhlmann, K. H. Kellner, S. Schott, C. Plass, M. Platten, C. Gerhauser, S. Trump, C. A. Opitz
Date Published: No date defined
Publication Type: Not specified
PubMed ID: 28344890
Citation: Oncoimmunology. 2017 Jan 3;6(2):e1274477. doi: 10.1080/2162402X.2016.1274477. eCollection 2017.
Bericht über die neuesten Aktiväten des Brustkrebsforschungsprojektes MESI-STRAT
Creators: Petra Engele, Laia Monserrat
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Neuigkeiten aus dem MESI-STRAT Projekt und Konsortium
Creators: Cecilia Barile, Petra Engele, Anna-Sophia Egger
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
News about the MESI-STRAT project and consortium
Creators: Cecilia Barile, Petra Engele, Anna-Sophia Egger
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Creators: Petra Engele, Franziska Goertler, Basak Tektemur Altay, Jeroen Elassaiss-Schaap
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Creators: Petra Engele, Franziska Goertler, Basak Tektemur Altay, Jeroen Elassaiss-Schaap
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Creators: Petra Engele, Christiane Opitz, Mirja Tamara Prentzell, Anika Köck, Regina Berger, Carmen Albertini
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Creators: Petra Engele, Mirja Tamara Prentzell, Carmen Albertini, Regina Berger, Anika Köck, Christiane Opitz
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Project News June 2021
Creators: Petra Engele, Anika Köck, Mirja Tamara Prentzell
Submitter: Petra Engele
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
Neues vom MESI-STRAT Projekt Juni 2021
Creators: Petra Engele, Anika Köck, Mirja Tamara Prentzell
Submitter: Petra Engele
Investigations: No Investigations
Studies: No Studies
Assays: No Assays
In unserem MESI-STRAT Newsletter erfahren Sie Neuigkeiten über unser Konsortium und unsere Forschung
Creators: Petra Engele, Marta Palafox
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
In our newsletter you will learn all about our consortium and the progress of our research.
Creators: Petra Engele, Marta Palafox
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Newsletter mit Neuigkeiten aus unserem Projekt
Creators: Petra Engele, Alexander Heberle, Christiane Opitz, Daryl Shanley
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
News of our project
Creators: Petra Engele, Alexander Heberle, Christiane Opitz, Daryl Shanley
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Creator: Petra Engele
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Creator: Petra Engele
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Newsletter Oktober 2019 deutsche Fassung
Creators: Petra Engele, Tobias Anzeneder, Suraj Sharma
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item
Newsletter October 2019
Creators: Petra Engele, Tobias Anzeneder, Suraj Sharma
Submitter: Petra Engele
Investigations: 1 hidden item
Studies: 1 hidden item
Assays: 1 hidden item