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Petra Engele

About Petra Engele:
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SEEK ID: https://fairdomhub.org/people/1409

Location:  Austria

Expertise: project management

Tools: Not specified

ORCID: Not specified

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Project positions

MESI-STRAT (University Of Innsbruck)

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MESI-STRAT

MESI-STRAT: Systems Medicine of Metabolic-Signaling Networks -A New Concept for Breast Cancer Patient Stratification.
Breast cancer is a complex disease with high prevalence in the European Union and world-wide. 75%-80 of the patients have estrogen receptor-positive (ER)-positive tumors and are treated with endocrine therapies. Endocrine therapies, which block ER-driven tumor growth, show high efficacy. Yet, a significant proportion of the patients will eventually relapse with metastatic breast
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Programme: This Project is not associated with a Programme

Public web page: http://www.mesi-strat.eu

University Of Innsbruck

Country:  Austria

City: Innsbruck

Web page: https://www.uibk.ac.at/

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MESI-STRAT Newsletter June 2019
MESI-STRAT

First MESI-STRAT Newsletter June 2019

Creators: Petra Engele, Kathrin Thedieck, Tobias Anzeneder, Janina Leyk

Contributor: Petra Engele

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The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner
MESI-STRAT

Abstract (Expand)

All cells and organisms exhibit stress-coping mechanisms to ensure survival. Cytoplasmic protein-RNA assemblies termed stress granules are increasingly recognized to promote cellular survival under … stress. Thus, they might represent tumor vulnerabilities that are currently poorly explored. The translationinhibitory eIF2α kinases are established as main drivers of stress granule assembly. Using a systems approach, we identify the translation enhancers PI3K and MAPK/p38 as pro-stressgranule- kinases. They act through the metabolic master regulator mammalian target of rapamycin complex 1 (mTORC1) to promote stress granule assembly.When highly active, PI3K is the main driver of stress granules; however, the impact of p38 becomes apparent as PI3K activity declines. PI3K and p38 thus act in a hierarchical manner to drive mTORC1 activity and stress granule assembly. Of note, this signaling hierarchy is also present in human breast cancer tissue. Importantly, only the recognition of the PI3K-p38 hierarchy under stress enabled the discovery of p38’s role in stress granule formation. In summary, we assign a new prosurvival function to the key oncogenic kinases PI3K and p38, as they hierarchically promote stress granule formation.

Authors: Alexander Heberle, Patricia Razquin Navas, Miriam Langelaar-Makkinje, Katharina Kasack, Ahmed Sadik, Erik Faessler, Udo Hahn, Philip Marx-Stoelting, Christiane Opitz, Christine Sers, Ines Heiland, Sascha Schäuble, Kathrin Thedieck

Date Published: 28th Mar 2019

Journal: Life Sci. Alliance

MESI-STRAT Newsletter Oktober 2019 deutsch
MESI-STRAT

Newsletter Oktober 2019 deutsche Fassung

Creators: Petra Engele, Tobias Anzeneder, Suraj Sharma

Contributor: Petra Engele

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MESI-STRAT Newsletter October 2019
MESI-STRAT

Newsletter October 2019

Creators: Petra Engele, Tobias Anzeneder, Suraj Sharma

Contributor: Petra Engele

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