Projects

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Mission: We perform cutting-edge research on data generated by novel biomolecular technologies to address questions in pneumology. Towards this, we use biological high-throughput data, i.e., OMICs data, to gain insights into molecular and phenotypic traits and diseases using computational methods. We combine data, methodology and their applications in pneumology through interdisciplinary collaboration with mathematicians, computer scientists, biologists and physicians.

ABSTRACT – OVERALL The primary focus of the MIT/DFCI Center for Systems Biology of Glioblastoma is to understand the intersections between neurons, immune cells, and tumor cells in this deadly tumor. The lack of response to immunotherapy strategies despite prominent infiltrates of immune cells in many GBM highlights the immuno- suppressive nature of the GBM microenvironment and the importance of more clearly understanding the dynamic interactions at the tumor/immune interface. Similarly, interactions ...

The MIT Superfund Research Program was created in 2017 to be responsive to communities who live near Superfund Sites. In particular, the MIT team leverages scientific research, community engagement, and educational experiences to support people who are concerned about hazardous chemicals in their environment.

Carcinogenic contaminants threaten the health of people living in the Mystic River Watershed (near the Olin, Industriplex, and Wells G&H Superfund sites) and members of Native American ...

Understanding the spectrum of complex metastatic processes is important to the development of a comprehensive and cohesive understanding of cancer metastasis. The Metastasis Research Network (MetNet) supports collaborative, multidisciplinary projects that focus on several themes of the metastatic process and use integrative systems-level approaches.

MetNet is advancing the understanding of metastasis as a non-linear, dynamic, and emergent process, as well as revealing mechanistic insights of early ...

3T3 murine embryonic fibroblasts are used as feeder layers to support the proliferative potential of human primary keratinocytes during in vitro expansion for cell and gene therapy applications. To identify signals mediating this function, we analyzed fibroblast protein content using mass spectrometry. We compared the proteome of lethally irradiated fibroblasts used as feeder layers in two conditions: standard quality (SQ-FL) and low quality (LQ-FL) fibroblasts. Our findings highlight differences ...

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Function, control and engineering of microbial methylotrophy (FUNCEMM) is a project bringing together 2 teams from France and Austria focusing on synthetic methylotrophy.

This is a test project

Dies ist eine Beschreibung der Data Request DR_Levels

SUSPHIRE aims to provide a sustainable, low-cost biomanufacturing platform for the commercial production of insect pheromones.

Synthetic biology data management spreadsheet: https://fairdomhub.org/data_files/6036

A collaborative space to document, manage, and share BullNet’s data, models, protocols, and/or results.

Laura Maiorino led a project studying the precise injection of tumor cells using a technique called ultrasound guided injection (USGI).

This facility oversees experiments imaging animals for preclinical study of therapeutic intervention.

Shoulders Lab Collagen Publications

Model-based design of a biorefinery platform to valorise agrifood organic waste into odd-chain volatile fatty acids integrating technical and environmental criteria

The conversion of organic wastes by anaerobic fermentation (the so-called carboxylate platform) is one of the promising emerging biorefineries that allows valorising organic carbon to volatile fatty acids (VFA), which can be further processed as chemicals, biopolymers and biofuels. A major obstacle to the widespread of the carboxylate ...

Development of a lactic acid centred biorefinery scheme to valorize flexibly organic waste streams into biochemicals

Real-time smart monitoring of bioprocesses for efficient conversion of organic carbon to volatile fatty acids