Projects

Understanding the spectrum of complex metastatic processes is important to the development of a comprehensive and cohesive understanding of cancer metastasis. The Metastasis Research Network (MetNet) supports collaborative, multidisciplinary projects that focus on several themes of the metastatic process and use integrative systems-level approaches.

MetNet is advancing the understanding of metastasis as a non-linear, dynamic, and emergent process, as well as revealing mechanistic insights of early ...

Shoulders Lab Collagen Publications

Endometriosis research done by the Griffith lab (MIT) and the Goods lab (Dartmouth)

ABSTRACT – OVERALL The primary focus of the MIT/DFCI Center for Systems Biology of Glioblastoma is to understand the intersections between neurons, immune cells, and tumor cells in this deadly tumor. The lack of response to immunotherapy strategies despite prominent infiltrates of immune cells in many GBM highlights the immuno- suppressive nature of the GBM microenvironment and the importance of more clearly understanding the dynamic interactions at the tumor/immune interface. Similarly, interactions ...

About

This project houses all the publicly available datasets generated by the Hi-IMPAcTB consortium over the course of its 7+ years.

What is Hi-IMPAcTB?

Hi-IMPAcTB is an ambitious endeavor bringing together a team of international, interdisciplinary researchers to improve our understanding of host-pathogen interactions in the context of tuberculosis (TB). Funded by a multi-center contract from the NIH, the long-term goal of the consortium is to enable principled vaccine design by improving ...

The MIT Superfund Research Program was created in 2017 to be responsive to communities who live near Superfund Sites. In particular, the MIT team leverages scientific research, community engagement, and educational experiences to support people who are concerned about hazardous chemicals in their environment.

Carcinogenic contaminants threaten the health of people living in the Mystic River Watershed (near the Olin, Industriplex, and Wells G&H Superfund sites) and members of Native American ...

PhD project of Pauric Donnelly as part of the Talent4BBI programme

Cure-Q demo project to demonstrate how Fairdomseek works

This project bundles information about COVID-19 related studies and tools in Germany. It intends to provide an information hub for the different initiatives, their aims, their processes, standards and study protocols, as well as their available data and metadata. It is initiated by the German National Research Data Infrastructure for Personal Health Data (nfdi4health), a consortium that plans to establish a concept for a federated research data infrastructure for personal health data in Germany. ...

nfdi4health aims to create the most comprehensive inventory of German epidemiological, public health and clinical trial data to date. It builds a centralised data catalogue with elaborate search functionalities, sophisticated data access management, and a data analysis toolbox, while respecting stringent requirements for privacy concerning personal health data. Standardisation services ensure a high degree of interoperability. Use cases covering prototypical study types and areas of research show ...

Gene mutagenesis is a key technology in molecular biology and genetic engineering, enabling precise, controllable changes at specific DNA sites. It is essential for studying gene function, protein engineering, functional genomics, disease models, and industrial enzyme optimization. Creative Biogene leverages advanced platforms, mature strategies, and high-fidelity systems to provide efficient, accurate, and flexible one-stop gene mutagenesis solutions.

Experimental data that were previously hosted on the original version of BioDare (biodare.ed.ac.uk), which opened in 2009, please see https://doi.org/10.1007/978-1-4939-0700-7_2. BioDare was designed as a repository of rhythmic biological data, especially for 24-hour circadian rhythms, with specialised analytical routines for period, phase and amplitude estimation on each data timeseries. Most rhythms tested were measured using gene expression, either directly as RNA levels, or indirectly using ...

some Description

The Transversal–Longitudinal Pathogenetic Theory (TLPT) is a systems‑biology framework that models disease emergence, progression, and resolution through the interaction of master‑switch nodes, transversal fluxes, longitudinal architectural layers, and meta‑attractor dynamics. TLPT integrates causal chains, pathogenic axes, transversal flows, feedback loops, pathological attractors, and the transversal meta‑attractor into a unified pathogenetic pyramid composed of seven hierarchical levels. The ...

Due to its high chemical stability, the biodegradation of benzene is the most challenging amongst hydrocarbons. While oxygen-dependent oxygenases are employed by aerobic bacteria to overcome the energy barrier, the mechanism of anaerobic benzene biodegradation is still enigmatic. The sulfate-reducing, clonal enrichment culture BzS1 is capable of benzene degradation under anoxic conditions. In addition, the alkylbenzene toluene may be used as sole source of carbon and energy. In this project, the ...

Chronic kidney disease (CKD) affects around 9% of the global population and is the 12th leading cause of death (GBD Chronic Kidney Disease Collaboration 2020). Diabetic kidney disease (DKD) is the most common form of CKD, responsible for nearly half of all end-stage renal disease (ESRD) cases (Samsu 2021). Despite its high burden, progress in developing effective therapies has been slow, largely due to limited understanding of the underlying molecular mechanisms.

DKD is driven by complex and ...

Andrew Millar's research group, University of Edinburgh

The group around Nicole Radde specializes in the modeling, analysis, and simulation of biochemical systems. This especially includes parameter optimization and identification.

AIRC

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Medulloblastoma represents the most frequent malignant brain tumor in children, occurring in the cerebellum. At diagnosis, approximately 30% of patients show disseminated (metastatic) disease. Approximately 60% survival can be reached with multimodal treatment including operation, irradiation and chemotherapy. However, survivors suffer from significant side effects, including neurocognitive impairment, which is very severe in young age when the central nervous system is still developing. To reduce ...

Produktion von Ethylacetat aus Molkerückständen mit Kluyveromyces marxianus und Produktgewinnung mittels Membranverfahren

MS-Proteomics and Lipidomics raw data associate with the present research paper

MS-Proteomics raw data repository