Projects

HCM protocols from TEATIME members

Background: The immunoproteasome is expressed constitutively in immune cells alongside standard proteasomes and forms multiple mixed types of proteasome complexes. These mixed 20S proteasomes may have distinct proteolytic activities depending on their subunit composition and may thereby regulate immune cell function. Using site-specific versus pan-inhibitors of the immunoproteasome, we here aim to dissect the biological functions of the three active sites of the immunoproteasome for monocyte cell ...

The Academic Scientific Research Group is an organization dedicated to organizing both international and local scientific-practical conferences. Their official website, asr-conference.com, provides detailed information about upcoming events, submission guidelines, and other relevant resources.One of their notable events is the upcoming scientific-practical conference titled "The National-Social Significance of Music Education and Art in Today's Globalization Context: Issues and Solutions," scheduled ...

About

This project houses all the publicly available datasets generated by the Hi-IMPAcTB consortium over the course of its 7+ years.

What is Hi-IMPAcTB?

Hi-IMPAcTB is an ambitious endeavor bringing together a team of international, interdisciplinary researchers to improve our understanding of host-pathogen interactions in the context of tuberculosis (TB). Funded by a multi-center contract from the NIH, the long-term goal of the consortium is to enable principled vaccine design by improving ...

Aliivibrio Vl2 vs. Moritella viscosa

Vl2 vs M. viscosa

The group around Nicole Radde specializes in the modeling, analysis, and simulation of biochemical systems. This especially includes parameter optimization and identification.

This is only a test

A fundamental and enduring challenge for ecosystem managers developing risk and impact assessment tools is to predict the extent of impact that spilled oil can have on the immediate fish populations and on future generations. Modelling approaches are important tools for these assessments, but they currently suffer from two major shortcomings: 1) the failure to acknowledge that effects can be transferred through several generations and 2) the assumption that a small group of toxic compounds, ...

This study investigated whether potentially harmful microorganisms from research laboratories and biotechnology companies can survive in nearby water systems. It focused on three Dutch cities - Leiden, Delft, and Alphen aan den Rijn - and collected water samples between May and September 2024.

The current project is created as a potential repository for resources resulting from the Virtual Human Platform for Safety Assessment (VHP4Safety) project.

A healthy lifestyle is the basis for adequate management in cardiovascular and other chronic conditions. The BENEFIT program aims to provide long-term support to patients with cardiovascular disease (CVD) in their own home with a healthy lifestyle.The FAIR Data approach in BENEFIT standardises and structures the data collected in the project, for better use and reuse. This metadata record describes the data available and provides a contact point for researchers who would like to apply to use the ...

This project collects and maintains minimum information metadata templates designed and used in the National NL-Bioimaging initiative. The templates are based on the REMBI standards and contribute to FAIR bioimaging data in the Netherlands, together with data management in the OMERO database.

Fit-for-purpose cascaded-approach for water and resource recovery from food industry wastewaterFood industry produces large amounts of wastewater with significant contents of organic carbon, nutrients and added-value compounds at low concentrations that can be recovered following a cascaded approach based on a specifically designed sequence of technologies. However, the diversity and seasonality of industrial wastewater streams, i.e. in terms of composition, concentration, temperature, etc. ...

A test project for EDITH, under which the models for testing the SEEK-EDITH integration are located.

This folder contains the Standard Operating Procedures (SOPs) of the Drug Discovery and Biotechnology

Towards the Digital Salmon: From a reactive to a pre-emptive research strategy in aquaculture (DigiSal)

Salmon farming in the future must navigate conflicting and shifting demands of sustainability, shifting feed prices, disease, and product quality. The industry needs to develop a flexible, integrated basis of knowledge for rapid response to new challenges. Project DigiSal will lay the foundations for a Digital Salmon: an ensemble of mathematical descriptions of salmon physiology, combining ...

Ionizing radiation (IR) leads to DNA double-strand breaks and can therefore be used as cancer treatment. However, some tumors are less responsive to radiation treatment because of their underlying molecular profile. Our ultimate goal is to understand the reaction of lung cancer cells with different phenotypes to IR on a molecular level to then provide the best therapy options for lung cancer patients with IR therapy.

OLCIR is funded by the Federal Ministry for Education and Research (BMBF, ...

Model-based design of a biorefinery platform to valorise agrifood organic waste into odd-chain volatile fatty acids integrating technical and environmental criteria

The conversion of organic wastes by anaerobic fermentation (the so-called carboxylate platform) is one of the promising emerging biorefineries that allows valorising organic carbon to volatile fatty acids (VFA), which can be further processed as chemicals, biopolymers and biofuels. A major obstacle to the widespread of the carboxylate ...

What is PlaSMo? PlaSMo stands for Plant Systems-biology Modelling Ensuring the achievements of yesterday's Mathematical Modellers will be available for the Systems Biologists of tomorrow.

Our aims

To identify plant mathematical models useful to the UK plant systems biology community, which are currently in a variety of legacy formats and in danger of being lost To represent these models in a declarative XML-based format, which is closer to the systems biology standard SBML To evaluate the behaviour ...

FAIRDOM will establish a support and service network for European Systems Biology. We will serve projects in standardising, managing and disseminating data and models in a FAIR manner: Findable, Accessible, Interoperable and Reusable.