Projects
What is a Project?The PETzyme project's objective is to develop an enzymatic technology for recycling polyethylene terephthalate (PET) wastes using free and immobilized PET hydrolases. We aim to obtain biocatalysts with enhanced thermostability, and we will take advantage of all recent works where protein engineering was used to improve the stability and catalytic efficiency of these enzymes, thus increasing the competitiveness of this recycling process.
Programme: WooBAdh
Public web page: Not specified
Up-regulation of glycolytic flux (glucose to lactate conversion), also known as the “Warburg effect”, has been associated with 90% of cancers. We implemented a systems biology approach in order to improve the overall understanding of the “Warburg effect” as well as identifying drug targets within the glycolytic pathway.
Programme: SARCHI: Mechanistic modelling of health and epidemiology
Public web page: Not specified
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SUSPHIRE aims to provide a sustainable, low-cost biomanufacturing platform for the commercial production of insect pheromones.
Programme: NIBSys
Public web page: http://susphire.info/susphireproject/
Start date: 1st Apr 2018
End date: 30th Sep 2021
supplementary materials
Programme: Independent Projects
Public web page: Not specified
Developing a placenta on a chip
Programme: Independent Projects
Public web page: https://www.iplacenta.eu/
Start date: 1st Jan 2018
End date: 31st May 2022
Programme: Independent Projects
Public web page: Not specified
This work aims to identify the biochemical pathways of THP-1 human monocytes infected by different Leishmania infantum clinical isolates from patients with either resistance or with TF outcome, using whole cell differential Mass Spectrometry proteomics. Network enrichment analysis was adopted to integrate the transcriptomics and the proteomic results of infected cells studies. Transferrin Receptor C and Nucleoside Diphosphate Kinase 3 were discovered as overexpressed proteins in THP-1 cells ...
Programme: Independent Projects
Public web page: Not specified
The placenta remains the key to maternal diseases such as Pre-eclampsia (PE) and Intrauterine growth restriction (IUGR), however the pathophysiology of these disorders remains elusive. The aim of this study is to characterize the key proteomic variations between PE and IUGR, to better understand the pathoetiology of these diseases.Term placentas each were collected from PE, IUGR pregnancies, and age and BMI matched healthy controls. Quadrupole-orbitrap mass spectrometer was used in data dependent ...
Programme: iPlacenta: A European Union Horizon 2020 innovative training network (ITN)
Public web page: Not specified
Placental dysfunction has been associated with various pregnancy complications leading to both maternal and fetal death and long-term consequences, however, the placenta is one of the least studied organs within the human body. In this pilot study, protein signature of three healthy placentae was measured using label free quantification mass spectrometry. Each placenta was sampled in five sample sites and three sub-anatomical regions. Differentially expressed proteins were identified considering ...
Programme: iPlacenta: A European Union Horizon 2020 innovative training network (ITN)
Public web page: Not specified
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Programme: LiSyM - Systems Medicine of the Liver
Public web page: Not specified
Programme: This Project is not associated with a Programme
Public web page: Not specified
The project "INtegrative COllaborative modeling in systems MEdicine" aims at connecting different heterogenous datasets and individual models within systems medicine.
Programme: e:med
Public web page: Not specified
Increasing temperature in the European wine producing regions is having a negative impact on this key sector. Climate change results in a lack of balance between technological and phenolic ripening of wine grapes and, as a consequence, alcohol increase in wines. This trend is of great concern for the European wine industry because it has a negative impact on wine quality, becomes a hurdle for international trade, and jeopardizes compatibility of moderate wine consumption with a healthy lifestyle. ...
Programme: CoolWine
Public web page: Not specified
The main idea of MIX-UP (MIXed plastics biodegradation and UPcycling using microbial communities) is to showcase a novel approach for plastic recycling and therefore addresses one of the greatest challenges of our time: the establishment of a circular (bio)-economy for plastics. The continuing demand for plastic products, the lack of appropriate recycling and the ubiquitous pollution of the environment with plastic waste pose a global challenge. An ambitious vision and considerable efforts are ...
Programme: de.NBI Systems Biology Service Center (de.NBI-SysBio)
Public web page: https://www.mix-up.eu/
Programme: Model repository for M4 (Make Me My Model) clients of ISBE
Public web page: Not specified
Programme: Model repository for M4 (Make Me My Model) clients of ISBE
Public web page: Not specified
Using standard systems biology methodologies a 14-compartment dynamic model was developed for the Corona virus epidemic. The model predicts that: (i) it will be impossible to limit lockdown intensity such that sufficient herd immunity develops for this epidemic to die down, (ii) the death toll from the SARS-CoV-2 virus decreases very strongly with increasing intensity of the lockdown, but (iii) the duration of the epidemic increases at first with that intensity and then decreases again, such that ...
Programme: Model repository for M4 (Make Me My Model) clients of ISBE
Public web page: Not specified
Start date: 1st Mar 2020
End date: 24th Mar 2023
In this proposal, we aim the sequential multivalorization of apple pomace towards the extraction of polyphenolics, the production of enzymes and its biological conversion into acetone-butanol-ethanol (ABE)
IMOMESIC - Integrating Modelling of Metabolism and Signalling towards an Application in Liver Cancer
One of the most challenging questions in cancer research is currently the interconnection of metabolism and signalling. An understanding of mechanisms that facilitate the physiological shift towards a proliferative metabolism in cancer cells is considered a major upcoming topic in oncology and is a key activity for future drug development. Due to the complexity of interrelations, a systems biology ...
Programme: ERASysAPP
Public web page: Not specified
Storage of thermophysical properties (e.g. density, viscosity, thermodynamic activity of water, conductivity) using Chemical Markup Language (CML).
Programme: This Project is not associated with a Programme
Public web page: Not specified
This project bundles information about COVID-19 related studies and tools in Germany. It intends to provide an information hub for the different initiatives, their aims, their processes, standards and study protocols, as well as their available data and metadata. It is initiated by the German National Research Data Infrastructure for Personal Health Data (nfdi4health), a consortium that plans to establish a concept for a federated research data infrastructure for personal health data in Germany. ...
Programme: ERNEST - European Research Network on Signal Transduction
Public web page: Not specified
Programme: SARCHI: Mechanistic modelling of health and epidemiology
Public web page: Not specified
What is PlaSMo? PlaSMo stands for Plant Systems-biology Modelling Ensuring the achievements of yesterday's Mathematical Modellers will be available for the Systems Biologists of tomorrow.
Our aims
To identify plant mathematical models useful to the UK plant systems biology community, which are currently in a variety of legacy formats and in danger of being lost
To represent these models in a declarative XML-based format, which is closer to the systems biology standard SBML To evaluate the behaviour ...
Programme: SynthSys
Public web page: Not specified
This project aims to characterise the mechanisms through which microRNAs and small non-coding RNAs act to regulate cellular processes focusing on Naïve CD4 T cell activation and viral replication - namely HIV - and to explore their potential use as a therapeutic co-adjuvant agents or targets.