MIT SRP
OverviewProgramme: NExtSEEK
SEEK ID: https://fairdomhub.org/projects/221
Public web page: Not specified
Organisms: No Organisms specified
FAIRDOM PALs: No PALs for this Project
Project created: 12th Jan 2021
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Projects: Hi-IMPAcTB, MIT SRP, MetNet, Endometriosis, Cancer Systems Biology Consortium (CSBC), Shoulders Lab
Institutions: Massachusetts Institute of Technology
Projects: Hi-IMPAcTB, MIT SRP, MetNet
Institutions: Massachusetts Institute of Technology
Projects: MIT SRP, Hi-IMPAcTB, MetNet
Institutions: Massachusetts Institute of Technology
https://orcid.org/0000-0001-7363-562X
Projects: Hi-IMPAcTB, MetNet, MIT SRP
Institutions: MIT, Massachusetts Institute of Technology
Projects: Hi-IMPAcTB, MIT SRP
Institutions: Massachusetts Institute of Technology
Researcher at BioMIcro Center, Data Management and Analysis Core; Massachusetts Institute of Technology
Projects: Hi-IMPAcTB, MIT SRP
Institutions: Massachusetts Institute of Technology
Projects: MIT SRP, Hi-IMPAcTB, MetNet, Endometriosis, Cancer Systems Biology Consortium (CSBC), Shoulders Lab
Web page: https://nextseek.mit.edu/
Submitter: Dikshant Pradhan
Studies: Benthic fluxes of fluorescent dissolved organic material, salt and heat ..., Colorimetric Detection of Aqueous N-Nitrosodimethylamine via Photonitros..., CometChip Enables Parallel Analysis of Multiple DNA Repair Activities, Excision of mutagenic replication-blocking lesions suppresses cancer but..., Interaction of N-Nitroamines with Bincuelar Copper Complexs for Luminsec..., Molecular origins of mutational spectra produced by the environmental ca..., Novel In Vivo CometChip Reveals NDMA-Induced DNA Damage and Repair in Mu..., Optical Detection of Interleukin-6 using Liquid Janus Emulsions using Hy..., Reversible Electrochemical Sensor for NDMA: Leveraging Molecularly Impri..., Youth Dictates Susceptibility to DNA Damage-Induced Genotoxicity, Mutage...
Assays: Absorption and Emission Spectroscopy - Data Linked, Absorption and Emission Spectroscopy Analysis - Data Linked, Agglutination Assay - Data Linked, All Metadata, All Metadata, Atomic Force Microscopy - Data Linked, Chemical Challenge - Metadata, Chemical Simulations - Data Linked, Chemical Synthesis - Metadata, Chemical Synthesis - Metadata, Chemical Synthesis - Metadata, Chemical Synthesis - Metadata, Comet Chip - Data Linked, Comet Chip Analysis - Data Attached, Comet Chip Analysis - Data Attached, Crystallography - Data Linked, Electrochemical Sensor Testing - Data Linked, Electron Paramagnetic Resonance - Data Linked, Extraction and Library Creation - Metadata, Field Water Sensor Run, Fourier Transform Infrared Spectroscopy - Data Linked, GPT Assay - Data Attached, GPT Assay – Data Attached, Gel Permeation Chromatography - Data Linked, Genome Alignment - Data Linked, High Resolution Mass Spectra - Data Linked, High Resolution Mass Spectra Analysis - Data Linked, Illumina Sequencing - Data Linked, Imaging - Data Linked, Mass Spectrometry Processing – Data Linked, Mass Spectrometry – Data Linked, Mouse Necropsy – Metadata, Mutational Spectral Analysis - Data Attached, Necropsy - Metadata, Nuclear Magnetic Resonance - Data Linked, Nuclear Magnetic Resonance Analysis - Data Linked, Nuclear Magnetic Resonance Spectroscopy - Data Linked, Nuclear Magnetic Resonance Spectroscopy - Data Linked, Nuclear Magnetic Resonance Spectroscopy Analysis - Data Linked, Nuclear Magnetic Resonance Spectroscopy Analysis - Data Linked, Pendant Drop Tensiometry - Data Linked, RaDR Image Machine Learning Analysis – Data Attached, Sensor Creation - Metadata, Single-crystal X-ray Crystallography - Data Linked, Tissue Collection - Metadata, Tissue Imaging – Metadata, Tissue Lysis – Metadata, UV-Vis Spectroscopy - Data Linked, UV-Vis Spectroscopy Analysis - Data Linked, X-ray Photoelectron Spectroscopy - Data Linked
The data / metadata will be available ** online** at the time of paper acceptance. If you would like access prior to acceptance, please reach out to Lindsay Volk: (lvolk@mit.edu)
Zhewen Guo, Haosheng Feng, Timothy Swager
DOI: https://pubs.acs.org/doi/10.1021/acssensors.4c02462
Abstract: Herein, we present the development and evaluation of a molecularly imprinted polymer (MIP) sensor for the sensitive and selective detection of N-nitrosodimethylamine (NDMA) in aqueous environments. MIP coatings over electrochemically active electrodes enable NDMA detection with a notably low detection limit of 1.16 ppb. Our findings demonstrate that the ...
Michelle Chen, Elliot I. Corless, Bevin P. Engelward, Timothy M. Swager
Link to Paper: https://pubs.acs.org/doi/full/10.1021/acsomega.4c03959
Agglutination of liquid Janus emulsions creates optical signals that can be detected and quantified. This study reports the detection and quantitation of Interleukin-6 (IL-6) using emulsions functionalized at the water-organic interface with engineered hyperthermophilic affinity proteins (rcSso7d) derived from ...
Submitter: Charles Demurjian
Investigation: MIT SRP
Assays: Agglutination Assay - Data Linked, All Metadata, Chemical Synthesis - Metadata, Fourier Transform Infrared Spectroscopy - Data Linked, Gel Permeation Chromatography - Data Linked, Nuclear Magnetic Resonance Spectroscopy - Data Linked, Nuclear Magnetic Resonance Spectroscopy Analysis - Data Linked, Pendant Drop Tensiometry - Data Linked
Jessica C. Beard, Chi-Hsien Wang, Arun Sridharan, Robert G. Croy, John M. Essigmann, Timothy M. Swager
Link to Paper: https://doi.org/10.1021/acssensors.4c00927
N-Nitrosamines are contaminants found throughout the environment, including in drinking water, and many nitrosamines are likely potent carcinogens. Correspondingly, there is need for rapid and cost-effective in-field detection methods that can provide timely information about their contamination ...
Submitter: Charles Demurjian
Investigation: MIT SRP
Assays: Chemical Synthesis - Metadata, Imaging - Data Linked, Nuclear Magnetic Resonance - Data Linked, Nuclear Magnetic Resonance Analysis - Data Linked, Single-crystal X-ray Crystallography - Data Linked, UV-Vis Spectroscopy - Data Linked, UV-Vis Spectroscopy Analysis - Data Linked
Jing Ge, Le P. Ngo, Simran Kaushal, Ian J. Tay, Elina Thadhani, Jennifer E. Kay, Patrizia Mazzucato, Danielle N. Chow, Jessica L. Fessler, David M. Weingeist, Robert W. Sobol, Leona D. Samson, Scott R. Floyd, Bevin P. Engelward,*
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439179/
DNA damage can be cytotoxic and mutagenic, and it is directly linked to aging, cancer, and other diseases. To counteract the deleterious effects of DNA damage, cells have ...
Norah Owiti, Joshua Corrigan, Lee Pribyl, Jennifer Kay, Bevin Engelward
https://doi.org/10.3390/ijms231911776
The comet assay is a versatile assay for detecting DNA damage in eukaryotic cells. The assay can measure the levels of various types of damage, including DNA strand breaks, abasic sites and alkali-sensitive sites. Furthermore, the assay can also be modified to include purified DNA glycosylases so that alkylated and oxidized bases can be detected. The ...
Submitter: Charles Demurjian
Investigation: MIT SRP
Assays: Chemical Challenge - Metadata, Comet Chip - Data Linked, Comet Chip Analysis - Data Attached, Tissue Collection - Metadata
Irene Hu and Harold Hemond
Aquatic eddy covariance (AEC) is an in situ technique for measuring fluxes in marine and freshwater systems based on the covariance of velocity and concentration measurements. Here, development of a fast multiple-channel sensor (FACT) enables the use of AEC for measurement of benthic fluxes of fluorescent dissolved organic material, salt, and heat at three distinct sites in Massachusetts, USA, including the ...
Jennifer E. Kay, Joshua J. Corrigan, Amanda L. Armijo, Ilana S. Nazari, Ishwar N. Kohale, Dorothea K. Torous, Svetlana L. Avlasevich, Robert G. Croy, Dushan N. Wadduwage, Sebastian E. Carrasco, Stephen D. Dertinger, Forest M. White, John M. Essigmann, Leona D. Samson, Bevin P. Engelward
doi: https://doi.org/10.1101/2021.01.12.426356
Link to all of the Imaging done in this study: https://omero.mit.edu/webclient/?show=project-153 ...
Haosheng Feng, Shao-Xiong Lennon Luo, Robert G Croy, John M. Essigmann, Timothy M. Swager
https://doi.org/10.1039/D2DT03848J
Cu(I) from tetrakis(acetonitrile)copper(I) hexafluorophosphate ([Cu(MeCN)4]PF6) was complexed with five structurally related phosphines containing N-heterocycles. The interactions between the resulting complexes and some N-nitrosamines were studied using X-ray crystallography as well as emission spectroscopy. Upon complexation, three ...
Submitter: Charles Demurjian
Investigation: MIT SRP
Assays: Absorption and Emission Spectroscopy - Data Linked, Absorption and Emission Spectroscopy Analysis - Data Linked, Chemical Synthesis - Metadata, Crystallography - Data Linked, Electron Paramagnetic Resonance - Data Linked, High Resolution Mass Spectra - Data Linked, High Resolution Mass Spectra Analysis - Data Linked, Nuclear Magnetic Resonance Spectroscopy - Data Linked, Nuclear Magnetic Resonance Spectroscopy Analysis - Data Linked, X-ray Photoelectron Spectroscopy - Data Linked
Amanda L. Armijo, Pennapa Thongaram, Bogdan I. Fedeles, Judy Yau, Jennifer E Kay, Joshua J. Corrigan, Marisa Chancharoen, Supawadee Chawanthayatham, Leona D. Samson, Sebastian E. Carrasco, Bevin P. Engelward, James G. Fox, Robert G. Croy & John M. Essigmann
DNA-methylating environmental carcinogens such as N-nitrosodimethylamine (NDMA) and certain alkylators used in chemotherapy form O6-methylguanine (m6G) as a functionally critical intermediate. NDMA ...
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Submitter: Dikshant Pradhan
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Submitter: Charles Demurjian
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Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
DownloadCreator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
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Batch sample publishing
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Batch sample publishing
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Batch sample publishing
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Batch sample publishing
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Batch sample publishing
Creator: Charles Demurjian
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Batch sample publishing
Creator: Charles Demurjian
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Creator: Charles Demurjian
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General SOP of the overall study - contains info from both the manuscript and supplementary information packet.
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
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Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
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Creator: Charles Demurjian
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Abstract
Authors: Jennifer E. Kay, Joshua J. Corrigan, Amanda L. Armijo, Ilana S. Nazari, Ishwar N. Kohale, Dorothea K. Torous, Svetlana L. Avlasevich, Robert G. Croy, Dushan N. Wadduwage, Sebastian E. Carrasco, Stephen D. Dertinger, Forest M. White, John M. Essigmann, Leona D. Samson, Bevin P. Engelward
Date Published: 1st Mar 2021
Publication Type: Journal
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HRMS try # 3
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HRMS 2
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HF
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