Colorimetric Detection of Aqueous N-Nitrosodimethylamine via Photonitrosation of a Naphtholsulfonate Indicator
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Jessica C. Beard, Chi-Hsien Wang, Arun Sridharan, Robert G. Croy, John M. Essigmann, Timothy M. Swager
Link to Paper: https://doi.org/10.1021/acssensors.4c00927
N-Nitrosamines are contaminants found throughout the environment, including in drinking water, and many nitrosamines are likely potent carcinogens. Correspondingly, there is need for rapid and cost-effective in-field detection methods that can provide timely information about their contamination levels in water. This study details a colorimetric assay for detecting aqueous N-nitrosodimethylamine (NDMA) by photochemical nitrosation of a commercial naphtholsulfonate, to offer an attractive alternative to traditional laboratory-based analysis. The resulting naphthoqui-none-oxime coordinates to aqueous iron (II) ions to form a green complex, allowing for direct visual detection. Characterization via Mössbauer and electron paramagnetic resonance (EPR) spectroscopy, alongside single-crystal structure determination, provides comprehensive structure information of the iron indicator complex. Optimization of detection conditions, including UV irradiation and response times, led to an improved colorimetric detection method with a limit of detection of 0.66 ppm for NDMA. The practical applicability and selectivity of this colorimetric detection scheme make it a promising candidate for the development of field-deployable sensors for NDMA in environmental water samples.
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Created: 16th May 2024 at 14:08
Last updated: 20th Aug 2024 at 19:08
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Projects: Hi-IMPAcTB, MIT SRP, MetNet, Endometriosis, Cancer Systems Biology Consortium (CSBC)
Institutions: Massachusetts Institute of Technology
Programme: MIT Superfund Research
Public web page: Not specified
Organisms: Not specified
Submitter: Dikshant Pradhan
Studies: Benthic fluxes of fluorescent dissolved organic material, salt and heat ..., Colorimetric Detection of Aqueous N-Nitrosodimethylamine via Photonitros..., CometChip Enables Parallel Analysis of Multiple DNA Repair Activities, Excision of mutagenic replication-blocking lesions suppresses cancer but..., Interaction of N-Nitroamines with Bincuelar Copper Complexs for Luminsec..., Molecular origins of mutational spectra produced by the environmental ca..., Novel In Vivo CometChip Reveals NDMA-Induced DNA Damage and Repair in Mu..., Optical Detection of Interleukin-6 using Liquid Janus Emulsions using Hy...
Assays: Absorption and Emission Spectroscopy - Data Linked, Absorption and Emission Spectroscopy Analysis - Data Linked, Agglutination Assay - Data Linked, All Metadata, Chemical Challenge - Metadata, Chemical Synthesis - Metadata, Chemical Synthesis - Metadata, Chemical Synthesis - Metadata, Comet Chip - Data Linked, Comet Chip Analysis - Data Attached, Comet Chip Analysis - Data Attached, Crystallography - Data Linked, Electron Paramagnetic Resonance - Data Linked, Extraction and Library Creation - Metadata, Field Water Sensor Run, Fourier Transform Infrared Spectroscopy - Data Linked, GPT Assay - Data Attached, GPT Assay – Data Attached, Gel Permeation Chromatography - Data Linked, Genome Alignment - Data Linked, High Resolution Mass Spectra - Data Linked, High Resolution Mass Spectra Analysis - Data Linked, Illumina Sequencing - Data Linked, Imaging - Data Linked, Mass Spectrometry Processing – Data Linked, Mass Spectrometry – Data Linked, Mouse Necropsy – Metadata, Mutational Spectral Analysis - Data Attached, Necropsy - Metadata, Nuclear Magnetic Resonance - Data Linked, Nuclear Magnetic Resonance Analysis - Data Linked, Nuclear Magnetic Resonance Spectroscopy - Data Linked, Nuclear Magnetic Resonance Spectroscopy - Data Linked, Nuclear Magnetic Resonance Spectroscopy Analysis - Data Linked, Nuclear Magnetic Resonance Spectroscopy Analysis - Data Linked, Pendant Drop Tensiometry - Data Linked, RaDR Image Machine Learning Analysis – Data Attached, Single-crystal X-ray Crystallography - Data Linked, Tissue Collection - Metadata, Tissue Imaging – Metadata, Tissue Lysis – Metadata, UV-Vis Spectroscopy - Data Linked, UV-Vis Spectroscopy Analysis - Data Linked, X-ray Photoelectron Spectroscopy - Data Linked
Snapshots: No snapshots
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.SWA-240522-V1_CW-NaphthosulfonateIndicator.docx
Data files: samples-publish2024-05-22-CHM.xlsx
Snapshots: No snapshots
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.SWA-240522-V1_CW-NaphthosulfonateIndicator.docx
Data files: samples-publish2024-05-22-CHM.xlsx, samples-publish2024-05-22-D.XRS.xlsx
Snapshots: No snapshots
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.SWA-240522-V1_CW-NaphthosulfonateIndicator.docx
Data files: samples-publish2024-05-22-CHM.xlsx, samples-publish2024-05-22-D.SPC.xlsx
Snapshots: No snapshots
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.SWA-240522-V1_CW-NaphthosulfonateIndicator.docx
Data files: samples-publish2024-05-22-A.SPC.xlsx, samples-publish2024-05-22-D.SPC.xlsx
Snapshots: No snapshots
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.SWA-240522-V1_CW-NaphthosulfonateIndicator.docx
Data files: samples-publish2024-03-12-D.NMR.xlsx, samples-publish2024-05-22-CHM.xlsx
Snapshots: No snapshots
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.SWA-240522-V1_CW-NaphthosulfonateIndicator.docx
Data files: samples-publish2024-03-12-D.NMR.xlsx, samples-publish2024-05-22-A.NMR
Snapshots: No snapshots
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.SWA-240522-V1_CW-NaphthosulfonateIndicator.docx
Data files: samples-publish2024-05-22-CHM.xlsx, samples-publish2024-05-22-D.IMG.xlsx, samples-publish2024-05-22-D.XRS.xlsx
Snapshots: No snapshots
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: MIT SRP
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: MIT SRP
Studies: Colorimetric Detection of Aqueous N-Nitrosodime...
Assays: UV-Vis Spectroscopy - Data Linked, UV-Vis Spectroscopy Analysis - Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: MIT SRP
Studies: Colorimetric Detection of Aqueous N-Nitrosodime...
Assays: Nuclear Magnetic Resonance - Data Linked, Nuclear Magnetic Resonance Analysis - Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: MIT SRP
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: MIT SRP
Studies: Colorimetric Detection of Aqueous N-Nitrosodime...
Assays: Imaging - Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: MIT SRP
Studies: Colorimetric Detection of Aqueous N-Nitrosodime...
Assays: Imaging - Data Linked, Single-crystal X-ray Crystallography - Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
General SOP of the overall study - contains info from both the manuscript and supplementary information packet.
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: MIT SRP
Studies: Colorimetric Detection of Aqueous N-Nitrosodime...
Assays: Chemical Synthesis - Metadata, Imaging - Data Linked, Nuclear Magnetic Resonance - Data Linked, Nuclear Magnetic Resonance Analysis - Data Linked, Single-crystal X-ray Crystallography - Data Linked, UV-Vis Spectroscopy - Data Linked, UV-Vis Spectroscopy Analysis - Data Linked