
Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

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Jennifer E. Kay, Joshua J. Corrigan, Amanda L. Armijo, Ilana S. Nazari, Ishwar N. Kohale, Dorothea K. Torous, Svetlana L. Avlasevich, Robert G. Croy, Dushan N. Wadduwage, Sebastian E. Carrasco, Stephen D. Dertinger, Forest M. White, John M. Essigmann, Leona D. Samson, Bevin P. Engelward doi: https://doi.org/10.1101/2021.01.12.426356
Link to all of the Imaging done in this study: https://omero.mit.edu/webclient/?show=project-153
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Created: 29th Mar 2021 at 18:34
Last updated: 15th Dec 2022 at 21:19
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- Assays (7)
- Data files (11)
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- Publications (1)
Institutions: Massachusetts Institute of Technology
Researcher at BioMIcro Center, Data Management and Analysis Core; Massachusetts Institute of Technology
Programme: MIT Superfund Research
Public web page: Not specified
Organisms: Not specified
Submitter: Dikshant Pradhan
Studies: Benthic fluxes of fluorescent dissolved organic material, salt and heat ..., Excision of mutagenic replication-blocking lesions suppresses cancer but..., Interaction of N-Nitroamines with Bincuelar Copper Complexs for Luminsec..., Molecular origins of mutational spectra produced by the environmental ca...
Assays: Absorption and Emission Spectroscopy - Data Linked, Absorption and Emission Spectroscopy Analysis - Data Linked, Chemical Synthesis - Metadata, Crystallography - Data Linked, Electron Paramagnetic Resonance - Data Linked, Extraction and Library Creation - Metadata, Field Water Sensor Run, GPT Assay - Data Attached, GPT Assay – Data Attached, Genome Alignment - Data Linked, High Resolution Mass Spectra - Data Linked, High Resolution Mass Spectra Analysis - Data Linked, Illumina Sequencing - Data Linked, Mass Spectrometry Processing – Data Linked, Mass Spectrometry – Data Linked, Mouse Necropsy – Metadata, Mutational Spectral Analysis - Data Attached, Necropsy - Metadata, Nuclear Magnetic Resonance Spectroscopy - Data Linked, Nuclear Magnetic Resonance Spectroscopy Analysis - Data Linked, RaDR Image Machine Learning Analysis – Data Attached, Tissue Imaging – Metadata, Tissue Lysis – Metadata, X-ray Photoelectron Spectroscopy - Data Linked
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.ENG-200806-V2_Short-Term-Collection-at-Necrop..., P.ENG-201008-V1_Med-Term-Collection-at-Necropsy...
Data files: samples-publish2021-03-30_16-25.xlsx, samples-publish2021-03-30_17-38.xlsx, samples-publish2021-09-20_22-36.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: No SOPs
Data files: samples-publish2021-03-30_16-04.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: No SOPs
Data files: samples-publish2021-03-30_15-51.xlsx, samples-publish2021-03-30_17-07.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: No SOPs
Data files: samples-publish2021-03-30_14-31.xlsx, samples-publish2021-03-30_15-51.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: No SOPs
Data files: samples-publish2021-03-30_17-07.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.ESS-201123-V1_gpt-NextGen-Protocol.pdf
Data files: 10.1016.j.celrep.2021.108864_GPT_assay, D.GPT-samples-publish2021-12-13_23-22.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: No SOPs
Data files: A.IMG-samples-publish2021-12-13_22-22.xlsx, WAD_RaDR_roi_extraction_10.1016.j.celrep.2021.1..., samples-publish2021-03-30_16-04.xlsx
Snapshots: No snapshots
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: GPT Assay – Data Attached
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mouse Necropsy – Metadata
GPT Assay results for "Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice" by Kay et al. https://doi.org/10.1016/j.celrep.2021.108864
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: GPT Assay – Data Attached
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mouse Necropsy – Metadata
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mouse Necropsy – Metadata
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mass Spectrometry – Data Linked, Tissue Lysis – Metadata
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: RaDR Image Machine Learning Analysis – Data Att..., Tissue Imaging – Metadata
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mass Spectrometry Processing – Data Linked, Mass Spectrometry – Data Linked
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Next-Gen GPT Assay Protocol
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: GPT Assay – Data Attached
Collection of Tissues at Necropsy of Short-Term Animals
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mouse Necropsy – Metadata
Medium-Term Tissue Collection at Necropsy
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mouse Necropsy – Metadata
Abstract
Authors: Jennifer E. Kay, Joshua J. Corrigan, Amanda L. Armijo, Ilana S. Nazari, Ishwar N. Kohale, Dorothea K. Torous, Svetlana L. Avlasevich, Robert G. Croy, Dushan N. Wadduwage, Sebastian E. Carrasco, Stephen D. Dertinger, Forest M. White, John M. Essigmann, Leona D. Samson, Bevin P. Engelward
Date Published: 1st Mar 2021
Publication Type: Journal
DOI: 10.1016/j.celrep.2021.108864
Citation: Cell Reports 34(11):108864