Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice
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Jennifer E. Kay, Joshua J. Corrigan, Amanda L. Armijo, Ilana S. Nazari, Ishwar N. Kohale, Dorothea K. Torous, Svetlana L. Avlasevich, Robert G. Croy, Dushan N. Wadduwage, Sebastian E. Carrasco, Stephen D. Dertinger, Forest M. White, John M. Essigmann, Leona D. Samson, Bevin P. Engelward
doi: https://doi.org/10.1101/2021.01.12.426356
Link to all of the Imaging done in this study: https://omero.mit.edu/webclient/?show=project-153
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Created: 29th Mar 2021 at 16:34
Last updated: 4th Aug 2023 at 13:59
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Projects: Hi-IMPAcTB, MIT SRP
Institutions: Massachusetts Institute of Technology
Researcher at BioMIcro Center, Data Management and Analysis Core; Massachusetts Institute of Technology
Programme: MIT Superfund Research
Public web page: Not specified
Organisms: Not specified
Submitter: Dikshant Pradhan
Studies: Benthic fluxes of fluorescent dissolved organic material, salt and heat ..., Colorimetric Detection of Aqueous N-Nitrosodimethylamine via Photonitros..., CometChip Enables Parallel Analysis of Multiple DNA Repair Activities, Excision of mutagenic replication-blocking lesions suppresses cancer but..., Interaction of N-Nitroamines with Bincuelar Copper Complexs for Luminsec..., Molecular origins of mutational spectra produced by the environmental ca..., Novel In Vivo CometChip Reveals NDMA-Induced DNA Damage and Repair in Mu..., Optical Detection of Interleukin-6 using Liquid Janus Emulsions using Hy...
Assays: Absorption and Emission Spectroscopy - Data Linked, Absorption and Emission Spectroscopy Analysis - Data Linked, Agglutination Assay - Data Linked, All Metadata, Chemical Challenge - Metadata, Chemical Synthesis - Metadata, Chemical Synthesis - Metadata, Chemical Synthesis - Metadata, Comet Chip - Data Linked, Comet Chip Analysis - Data Attached, Comet Chip Analysis - Data Attached, Crystallography - Data Linked, Electron Paramagnetic Resonance - Data Linked, Extraction and Library Creation - Metadata, Field Water Sensor Run, Fourier Transform Infrared Spectroscopy - Data Linked, GPT Assay - Data Attached, GPT Assay – Data Attached, Gel Permeation Chromatography - Data Linked, Genome Alignment - Data Linked, High Resolution Mass Spectra - Data Linked, High Resolution Mass Spectra Analysis - Data Linked, Illumina Sequencing - Data Linked, Imaging - Data Linked, Mass Spectrometry Processing – Data Linked, Mass Spectrometry – Data Linked, Mouse Necropsy – Metadata, Mutational Spectral Analysis - Data Attached, Necropsy - Metadata, Nuclear Magnetic Resonance - Data Linked, Nuclear Magnetic Resonance Analysis - Data Linked, Nuclear Magnetic Resonance Spectroscopy - Data Linked, Nuclear Magnetic Resonance Spectroscopy - Data Linked, Nuclear Magnetic Resonance Spectroscopy Analysis - Data Linked, Nuclear Magnetic Resonance Spectroscopy Analysis - Data Linked, Pendant Drop Tensiometry - Data Linked, RaDR Image Machine Learning Analysis – Data Attached, Single-crystal X-ray Crystallography - Data Linked, Tissue Collection - Metadata, Tissue Imaging – Metadata, Tissue Lysis – Metadata, UV-Vis Spectroscopy - Data Linked, UV-Vis Spectroscopy Analysis - Data Linked, X-ray Photoelectron Spectroscopy - Data Linked
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.ENG-200806-V2_Short-Term-Collection-at-Necrop..., P.ENG-201008-V1_Med-Term-Collection-at-Necropsy...
Data files: samples-publish2021-03-30_16-25.xlsx, samples-publish2021-03-30_17-38.xlsx, samples-publish2021-09-20_22-36.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: No SOPs
Data files: samples-publish2021-03-30_16-04.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: No SOPs
Data files: samples-publish2021-03-30_15-51.xlsx, samples-publish2021-03-30_17-07.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: No SOPs
Data files: samples-publish2021-03-30_14-31.xlsx, samples-publish2021-03-30_15-51.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: No SOPs
Data files: samples-publish2021-03-30_17-07.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: P.ESS-201123-V1_gpt-NextGen-Protocol.pdf
Data files: 10.1016.j.celrep.2021.108864_GPT_assay, D.GPT-samples-publish2021-12-13_23-22.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MIT SRP
Organisms: No organisms
SOPs: No SOPs
Data files: A.IMG-samples-publish2021-12-13_22-22.xlsx, WAD_RaDR_roi_extraction_10.1016.j.celrep.2021.1..., samples-publish2021-03-30_16-04.xlsx
Snapshots: No snapshots
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mouse Necropsy – Metadata
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mass Spectrometry – Data Linked, Tissue Lysis – Metadata
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mouse Necropsy – Metadata
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mass Spectrometry Processing – Data Linked, Mass Spectrometry – Data Linked
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: RaDR Image Machine Learning Analysis – Data Att..., Tissue Imaging – Metadata
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: GPT Assay – Data Attached
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Batch sample publishing
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mouse Necropsy – Metadata
GPT Assay results for "Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice" by Kay et al. https://doi.org/10.1016/j.celrep.2021.108864
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: GPT Assay – Data Attached
Next-Gen GPT Assay Protocol
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: GPT Assay – Data Attached
Collection of Tissues at Necropsy of Short-Term Animals
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mouse Necropsy – Metadata
Medium-Term Tissue Collection at Necropsy
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: MIT SRP
Studies: Excision of mutagenic replication-blocking lesi...
Assays: Mouse Necropsy – Metadata
Abstract
Authors: Jennifer E. Kay, Joshua J. Corrigan, Amanda L. Armijo, Ilana S. Nazari, Ishwar N. Kohale, Dorothea K. Torous, Svetlana L. Avlasevich, Robert G. Croy, Dushan N. Wadduwage, Sebastian E. Carrasco, Stephen D. Dertinger, Forest M. White, John M. Essigmann, Leona D. Samson, Bevin P. Engelward
Date Published: 1st Mar 2021
Publication Type: Journal
DOI: 10.1016/j.celrep.2021.108864
Citation: Cell Reports 34(11):108864