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SEEK ID: https://fairdomhub.org/assays/2159

Class: Experimental assay

Projects: MIT SRP

Investigation: MIT SRP

Study: Novel In Vivo CometChip Reveals NDMA-Induced DNA Damage and Repair in Multiple Mouse Tissues

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Assay type: Experimental Assay Type

Technology type: Technology Type

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Creators and Submitter

Creator

Charles Demurjian

Submitter

Charles Demurjian

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Views: 544

Created: 13th Sep 2023 at 16:13

Last updated: 14th Apr 2025 at 18:05

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Charles Demurjian

Projects: Hi-IMPAcTB, MIT SRP, MetNet, Endometriosis, Cancer Systems Biology Consortium (CSBC)

Institutions: Massachusetts Institute of Technology

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NExtSEEK

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Projects: MIT SRP, Hi-IMPAcTB, MetNet, Endometriosis, Cancer Systems Biology Consortium (CSBC)

Web page: https://nextseek.mit.edu/

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MIT SRP

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Programme: NExtSEEK

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MIT SRP

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Dikshant Pradhan

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Submitter: Dikshant Pradhan

Studies: Benthic fluxes of fluorescent dissolved organic material, salt and heat ..., Colorimetric Detection of Aqueous N-Nitrosodimethylamine via Photonitros..., CometChip Enables Parallel Analysis of Multiple DNA Repair Activities, Excision of mutagenic replication-blocking lesions suppresses cancer but..., Interaction of N-Nitroamines with Bincuelar Copper Complexs for Luminsec..., Molecular origins of mutational spectra produced by the environmental ca..., Novel In Vivo CometChip Reveals NDMA-Induced DNA Damage and Repair in Mu..., Optical Detection of Interleukin-6 using Liquid Janus Emulsions using Hy..., Reversible Electrochemical Sensor for NDMA: Leveraging Molecularly Impri...

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Created: 29th Mar 2021 at 16:33

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Novel In Vivo CometChip Reveals NDMA-Induced DNA Damage and Repair in Multiple Mouse Tissues

MIT SRP

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Charles Demurjian

Norah Owiti, Joshua Corrigan, Lee Pribyl, Jennifer Kay, Bevin Engelward

https://doi.org/10.3390/ijms231911776

The comet assay is a versatile assay for detecting DNA damage in eukaryotic cells. The assay can measure the levels of various types of damage, including DNA strand breaks, abasic sites and alkali-sensitive sites. Furthermore, the assay can also be modified to include purified DNA glycosylases so that alkylated and oxidized bases can be detected. The ...