MetNet
OverviewUnderstanding the spectrum of complex metastatic processes is important to the development of a comprehensive and cohesive understanding of cancer metastasis. The Metastasis Research Network (MetNet) supports collaborative, multidisciplinary projects that focus on several themes of the metastatic process and use integrative systems-level approaches.
MetNet is advancing the understanding of metastasis as a non-linear, dynamic, and emergent process, as well as revealing mechanistic insights of early dissemination, cellular and physical microenvironment crosstalk, dormancy, and mechanisms of responses by metastatic cells to therapies. The network integrates multiple perspectives and expertise to advance metastasis research, including scientific experts in different fields, physicians, and research advocates.
Programme: NExtSEEK
SEEK ID: https://fairdomhub.org/projects/340
Public web page: Not specified
Organisms: No Organisms specified
FAIRDOM PALs: No PALs for this Project
Project created: 17th Feb 2023
TagsThis item has not yet been tagged.
Related items
Projects: Hi-IMPAcTB, MIT SRP, MetNet, Endometriosis, Cancer Systems Biology Consortium (CSBC), Shoulders Lab
Institutions: Massachusetts Institute of Technology
Projects: Hi-IMPAcTB, MIT SRP, MetNet
Institutions: Massachusetts Institute of Technology
Projects: MIT SRP, Hi-IMPAcTB, MetNet
Institutions: Massachusetts Institute of Technology
https://orcid.org/0000-0001-7363-562X
Projects: Hi-IMPAcTB, MetNet, MIT SRP
Institutions: MIT, Massachusetts Institute of Technology
Projects: MIT SRP, Hi-IMPAcTB, MetNet, Endometriosis, Cancer Systems Biology Consortium (CSBC), Shoulders Lab
Web page: https://nextseek.mit.edu/
Submitter: Charles Demurjian
Studies: Chromatin conformation, gene transcription, and nucleosome remodeling as..., Confined cell migration along extracellular matrix space in vivo, Impact of fibrinogen, fibrin thrombi and thrombin on cancer cell extrava..., Patient-specific vascularized tumor model: Blocking monocyte recruitment..., Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Bio..., Polyploidy of MDA-MB-231 cells drives increased extravasation with enhan..., Utilizing convolutional neural networks for discriminating cancer and st...
Assays: All Metadata, All Metadata, All Metadata, All Metadata, Cancer Cell Extravasation Analysis - Data Linked, Cancer Cell Extravasation Analysis - Data Linked, Cell Culture - Metadata, Cell Culture - Metadata, Cell Culture Imaging - Data Linked, Cell Culture Imaging Analysis - Data Linked, Cell Culture and Tumor Spheroid Creation - Metadata, Cell Culture and Tumor Spheroid Creation - Metadata, Cell Imaging - Data Linked, Chromatin Sequencing Analysis - Data Linked, Clot Modeling Analysis - Data Linked, Convolutional Neural Network - Data Linked, Device Creation - Metadata, Device Creation - Metadata, Device Imaging - Data Linked, Device Imaging - Data Linked, Device Imaging - Data Linked, Device Imaging - Metadata, Flow Cytometry - Data Linked, Flow Cytometry - Data Linked, Flow Cytometry Analysis - Data Linked, Flow Cytometry Analysis - Data Linked, Fluorescence-Activated Cell Sorting - Data Linked, Gene Expression Analysis - Data Linked, Imaging Analysis - Data Attached, Imaging Analysis - Data Linked, Imaging Analysis - Data Linked, Intravital Microscopy, Library Creation - Metadata, Library Prep - Metadata, Microfluidic Device Creation - Metadata, Microfluidic Device Creation - Metadata, Microfluidic Device Imaging - Data Linked, Microvascular Network Formation - Metadata, Migration Assay Analysis - Data Linked, Modeling - Data Linked, Permeability Analysis - Data Linked, RNA Extraction - Metadata, Real-time RT-PCR - Data Linked, Short Read Sequencing - Data Linked, Short Read Sequencing - Data Linked, Tumoroid Formation - Metadata
Oleksandr Chepizhkoa, Josep-Maria Armengol-Colladob, Stephanie Alexander, Esther Wagenae, Bettina Weigelin, Luca Giomi, Peter Friedl, Stefano Zapperi,Caterina A. M. La Porta
DOI: https://doi.org/10.1073/pnas.2414009121
Abstract: Cancer metastasis involves the collective migration of cancer cells in confined space, a problem that has been widely investigated in vitro. Here, we quantify the flow patterns of cancer cell as they invade tissue space and deform ...
Submitter: Charles Demurjian
Investigation: MetNet
Assays: All Metadata, Imaging Analysis - Data Linked, Intravital Microscopy
Luay M Almassalha 1 2, Marcelo Carignano 2 3, Emily Pujadas Liwag 2 4, Wing Shun Li 2 3 5, Ruyi Gong 2 3, Nicolas Acosta 2 3, Cody L Dunton 2 3, Paola Carrillo Gonzalez 2 3, Lucas M Carter 2 4, Rivaan Kakkaramadam 2 4, Martin Kröger 6, Kyle L MacQuarrie 7 8, Jane Frederick 2 3, I Chae Ye 2 3, Patrick Su 2 3, Tiffany Kuo 2 4, Karla I Medina 2 4, Josh A Pritchard 2 3, Andrew Skol 7, Rikkert Nap 2 3, Masato Kanemaki 9 10 11, Vinayak Dravid 5 12 13 14 15, Igal Szleifer 2 3 12, Vadim Backman 2 3 ...
Satomi Hirose, Tatusya Osaki, Roger D. Kamm
Link to Publication: https://doi.org/10.1101/2024.06.28.601261
Abstract: Metastasis, the leading cause of cancer-related deaths, involves a complex cascade of events, including extravasation. Despite extensive research into metastasis, the mechanisms underlying extravasation remain unclear. Molecular targeted therapies have advanced cancer treatment, yet their efficacy is limited, prompting exploration into novel ...
Submitter: Charles Demurjian
Investigation: MetNet
Assays: All Metadata, Cancer Cell Extravasation Analysis - Data Linked, Cell Culture - Metadata, Cell Culture Imaging - Data Linked, Cell Culture Imaging Analysis - Data Linked, Fluorescence-Activated Cell Sorting - Data Linked, Gene Expression Analysis - Data Linked, Library Prep - Metadata, Microfluidic Device Imaging - Data Linked, Microvascular Network Formation - Metadata, RNA Extraction - Metadata, Real-time RT-PCR - Data Linked, Short Read Sequencing - Data Linked
Huu Tuan Nguyen, Nadia Gurvich, Mark Robert Gillrie, Giovanni Offeddu, Mouhita Humayun, Ellen L. Kan, Zhengpeng Wan, Mark Frederick Coughlin, Christie Zhang, Vivian Vu, Sharon Wei Ling Lee, Seng-Lai Tan, David Barbie, Jonathan Hsu, Roger D. Kamm
Link to Paper: https://www.sciencedirect.com/science/article/abs/pii/S0142961224002655
Abstract: Tumor-associated inflammation drives cancer progression and therapy resistance, often linked to the infiltration of ...
Submitter: Charles Demurjian
Investigation: MetNet
Assays: All Metadata, Cell Culture and Tumor Spheroid Creation - Metadata, Device Imaging - Data Linked, Flow Cytometry - Data Linked, Flow Cytometry Analysis - Data Linked, Microfluidic Device Creation - Metadata, Migration Assay Analysis - Data Linked
Giovanni S. Offeddu#, Elena Cambria#, Sarah E. Shelton, Kristina Haase, Zhengpeng Wan, Luca Possenti, Huu Tuan Nguyen, Mark R. Gillrie, Dean Hickman, Charles G. Knutson, and Roger D. Kamm
Abstract: Desmoplasia in breast cancer leads to heterogeneity in physical properties of the tissue, resulting in disparities in drug delivery and treatment efficacy among patients, thus contributing to high disease mortality. Personalized in vitro breast cancer models hold ...
Submitter: Charles Demurjian
Investigation: MetNet
Assays: Device Creation - Metadata, Device Imaging - Metadata, Imaging Analysis - Data Attached, Tumoroid Formation - Metadata
Huu Tuan Nguyen, Nicholas Pietraszek, Sarah E. Shelton, Kwabena Arthur, Roger D. Kamm
Link to Paper:
Abstract: Significance: Accurate cell segmentation and classification in 3 dimensional (3D) images are vital for studying live cell behavior and drug responses in 3D tissue culture. Evaluating diverse cell populations in 3D cell culture over time necessitates non-toxic staining methods, as specific fluorescence tags may not be suitable and immunofluorescence ...
Emmanouil Angelidakis, Sophia Chen, Shun Zhang, Zhengpeng Wan, Roger D. Kamm, Sarah E. Shelton
Link to Paper: https://doi.org/10.1002/adhm.202202984
A bidirectional association exists between metastatic dissemination and the hypercoagulable state associated with many types of cancer. As such, clinical studies have provided evidence that markers associated with elevated levels of coagulation and fibrinolysis correlate with decreased patient survival. However, ...
Submitter: Charles Demurjian
Investigation: MetNet
Assays: Cancer Cell Extravasation Analysis - Data Linked, Clot Modeling Analysis - Data Linked, Device Imaging - Data Linked, Flow Cytometry - Data Linked, Flow Cytometry Analysis - Data Linked, Microfluidic Device Creation - Metadata, Permeability Analysis - Data Linked
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: MetNet
Creator: Charles Demurjian
Submitter: Charles Demurjian
DownloadBatch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
Creator: Charles Demurjian
Submitter: Charles Demurjian
UID (Text) *, File_PrimaryData (Text) , Link_PrimaryData (URI) , Parent (Text) , Scientist (Text) , DataType (Text) , Protocol (URI)
Not specified
UID (Text) *, Name (Text) , Parent (Text) , Type (Text) , Scientist (Text) , Protocol (URI) , Material (Text) , Media (Text)
Not specified
UID (Text) *, Name (Text) , Scientist (Text) , Type (Text) , StorageLocation (Text) , StorageSite (Text) , Protocol (URI) , Species (Text) , CellLine (Text) , Source (Text) , Media (Text) , Parent (Text)
Not specified
UID (Text) *, File_PrimaryData (Text) , Link_PrimaryData (URI) , Type (Text) , Scientist (Text) , Protocol_Analysis (URI) , Protocol_Model (URI) , Parent (Text) , Model_Type (Text)
Not specified
UID (Text) *, File_PrimaryData (Text) , Parent (Text) , Link_PrimaryData (URI) , Scientist (Text) , DataType (Text) , Protocol (URI) , Link_Code (URI)
Not specified
UID (Text) *, File_PrimaryData (Text) , Checksum_PrimaryData (Text) , Link_PrimaryData (URI) , Parent (Text) , Scientist (Text) , DataType (Text) , SampleCreationDate (Text) , Protocol (URI) , ImageTimepoint (Text)
Not specified
UID (Text) *, Name (Text) , Parent (Text) , Stimulation (Text) , Type (Text) , Scientist (Text) , Protocol (URI) , Material (Text) , Link_Design (URI)
Not specified
UID (Text) *, Name (Text) , Scientist (Text) , Type (Text) , StorageLocation (Text) , Parent (Text) , Protocol (URI) , Species (Text) , CellLine (Text) , Source (Text) , Media (Text)
Not specified
PERM KAMM
UID (Text) *, File_PrimaryData (Text) , Link_PrimaryData (Text) , Scientist (Text) , Type (Text) , Parent (Text) , Protocol (Text) , Checksum_PrimaryData (Text)
Not specified
CLOT KAmm
UID (Text) *, File_PrimaryData (Text) , Link_PrimaryData (Text) , Scientist (Text) , Type (Text) , Parent (Text) , Checksum_PrimaryData (Text) , Protocol (Text)
Not specified
CCE KAmm
UID (Text) *, File_PrimaryData (Text) , Link_PrimaryData (Text) , Scientist (Text) , Type (Text) , Parent (Text) , Protocol (Text) , Checksum_PrimaryData (Text)
Not specified
UID (Text) *, Name (Text) , Parent (Text) , Scientist (Text)
Not specified
Kamm
UID (Text) *, Name (Text) , Catalog# (Text) , Vendor (Text) , Analyte (Text) , Fluorophore (Text) , ExperimentType (Text) , CatalogLink (Text)
Not specified
Kamm
UID (Text) *, File_PrimaryData (Text) , Link_PrimaryData (Text) , Checksum_PrimaryData (Text) , Scientist (Text) , Parent (Text) , Protocol (Text)
Not specified
Kamm
UID (Text) *, File_PrimaryData (Text) , Link_PrimaryData (Text) , Scientist (Text) , SampleCreationDate (Text) , Parent (Text) , Protocol (Text) , Instrument (Text) , Checksum_PrimaryData (Text) , AntibodyParent (Text) , Type (Text) , Repository (Text) , RepositoryID (Text) , Timepoint (Text)
Not specified
D.IMG KAMM
UID (Text) *, File_PrimaryData (Text) , Link_PrimaryData (Text) , Scientist (Text) , Protocol (Text) , SampleCreationDate (Text) , Parent (Text) , DataType (Text) , Checksum_PrimaryData (Text) , StimulationDate (Text)
Not specified
OOC KAM
UID (Text) *, Name (Text) , Parent (Text) , Type (Text) , Stimulation (Text) , Scientist (Text) , Protocol (Text) , Protocol_Device (Text) , Material (Text)
Not specified
CEL KAM
UID (Text) *, Name (Text) , Type (Text) , Protocol (Text) , Scientist (Text) , StorageLocation (Text) , StorageSite (Text) , Species (Text) , CellLine (Text) , Source (Text) , Media (Text)
Not specified
