SEEK ID: https://fairdomhub.org/investigations/438
Projects: IMPAcTB
Investigation position:
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Created: 14th Jan 2021 at 16:10
Last updated: 18th Oct 2021 at 16:05

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Institutions: Massachusetts Institute of Technology
Researcher at BioMIcro Center, Data Management and Analysis Core; Massachusetts Institute of Technology
Projects: IMPAcTB
Web page: https://www.niaid.nih.gov/research/immune-mechanisms-protection-mycobacterium-tuberculosis
Meng Sun*, Jolie M. Phan*, Nathan S. Kieswetter, Krystle K.Q. Yu, Malisa T. Smith, Huang Huang, Sanjana Gupta, Gerlinde Obermoser, Holden Terry Maecker, Akshaya Krishnan, Neha Gupta, Mary Rieck, Peter Acs, Mustafa Ghanizada, Shin-Heng Chiou, Purvesh Khatri, W. Henry Boom, Thomas R. Hawn, Catherine M. Stein, Harriet Mayanja-Kizza, Mark M. Davis*, Chetan Seshadri*
Abstract: A subset of individuals with a high probability of exposure to M. tuberculosis (M.tb) ...
Submitter: Charles Demurjian
Investigation: IMPAcTB
Assays: Flow Cytometry - Data Linked, Flow Cytometry Analysis - Data Linked, Patient Visit - Metadata, Tissue Collection - Metadata
Snapshots: No snapshots
Thiel BA, Worodria W, Nalukwago S, Nsereko M, Sanyu I, Rejani L, Zawedde J, Canaday DH, Stein CM, Chervenak KA, Malone LL, Kiyemba R, Silver RF, Johnson JL, Mayanja-Kizza H, Boom WH. Immune cells in bronchoalveolar lavage fluid of Ugandan adults who resist versus those who develop latent Mycobacterium tuberculosis infection. PLoS One. 2021 Apr 9;16(4):e0249477. doi: 10.1371/journal.pone.0249477. PMID: 33836031; PMCID: PMC8034721.
Abstract: ...
Submitter: Dikshant Pradhan
Investigation: IMPAcTB
Assays: Flow Cytometry Processing – Data Attached, Flow Cytometry – Data Linked, Patient Visit – Metadata, Tissue Collection - Metadata
Snapshots: Snapshot 1, Snapshot 2
Submitter: Dikshant Pradhan
Investigation: IMPAcTB
Assays: Single Cell Sequencing Analysis – Data Linked, Single Cell Sequencing – Data Linked, Tissue Extraction – Metadata
Snapshots: Snapshot 1, Snapshot 2
Hannah P.Gideon, Travis K.Hughes, Constantine N.Tzouanas, Marc H.WadsworthII, Ang AndyTu, Todd M.Gierahn, Joshua M.Peters, Forrest F.Hopkins, Jun-RongWei, Conner Kummerlowe, Nicole L.Grant, Kievershen Nargan, Jia YaoPhuah, H. JacobBorish, Pauline Maiello, Alexander G.White, Caylin G.Winchell, Sarah K.Nyquist, Sharie Keanne C.Ganchua, Amy Myers, Kush V.Patel, Cassaundra L.Ameel, Catherine T.Cochran, Samira Ibrahim, Jaime A.Tomko, Lonnie JamesFrye, Jacob M.Rosenberg, Angela Shih, Michael Chao, Edwin ...
Submitter: Dikshant Pradhan
Investigation: IMPAcTB
Assays: Immunohistochemistry – Data Linked, Library Creation – Metadata, NHP Necropsy – Metadata, PET-CT Scan Analysis – Data Linked, PET-CT Scan – Data Linked, Patient Visit – Metadata, Single Cell Clustering Analysis – Data Linked, Single Cell Expression Matrix Analysis – Data Linked, Single Cell Sequencing – Data Linked
Snapshots: Snapshot 1
Edward B. Irvine, Joshua M. Peters, Richard Lu, Patricia S. Grace, Jaimie Sixsmith, Aaron Wallace, Matthew Schneider, Sally Shin, Wiktor Karpinski, Jeff C. Hsiao, Esther van Woudenbergh, Arturo Casadevall, Bryan D. Bryson, Lisa Cavacini, View ORCID ProfileGalit Alter, Sarah M. Fortune doi: https://doi.org/10.1101/2022.05.01.490220
Novel vaccination and therapeutic strategies are urgently needed to mitigate the tuberculosis (TB) epidemic. While extensive efforts have focused on potentiating ...
Snapshots: No snapshots
Development of an effective tuberculosis (TB) vaccine has suffered from an incomplete understanding of the correlates of protection against Mycobacterium tuberculosis (Mtb). Intravenous (i.v.) vaccination with Bacille Calmette–Guérin (BCG) provides nearly complete protection against TB in rhesus macaques, but the antibody response it elicits remains incompletely defined. Here we show that i.v. BCG drives superior antibody responses in the plasma and the lungs of rhesus macaques compared to ...
Submitter: Dikshant Pradhan
Investigation: IMPAcTB
Assays: Anti-Microbial Assay – Metadata, Functional Assay – Metadata, Luminex Assay – Metadata, Luminex Data Processing – Data Attached, NHP Tissue Collection – Metadata
Snapshots: Snapshot 1
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: No SOPs
Data files: CEX-samples-publish2022-01-28_00-10.xlsx, NHP-samples-publish2022-01-28_00-20.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.ALT-211020-V1_NHP-FcR-Luminex-Protocol-EI.doc, P.ALT-211020-V1_NHP-Isotype-Luminex-Protocol-EI..., P.ALT-211203-V1_BCG_study_EI_luminex_panel.xlsx
Data files: D.LMX-211203ALT-10_FcR_luminex_FcyR3A_plasma.xlsx, D.LMX-211203ALT-1_isotype_luminex_IgG1_BAL.xlsx, D.LMX-211203ALT-2_isotype_luminex_IgA_BAL.xlsx, D.LMX-211203ALT-3_isotype_luminex_IgM_BAL.xlsx, D.LMX-211203ALT-4_isotype_luminex_IgG1_plasma.xlsx, D.LMX-211203ALT-5_isotype_luminex_IgA_plasma.xlsx, D.LMX-211203ALT-6_isotype_luminex_IgM_plasma.xlsx, D.LMX-211203ALT-7_FcR_luminex_FcyR2A_BAL.xlsx, D.LMX-211203ALT-8_FcR_luminex_FcyR3A_BAL.xlsx, D.LMX-211203ALT-9_FcR_luminex_FcyR2A_plasma.xlsx, D.LMX-samples-publish2022-01-27_23-57.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.ALT-220127-V1_EI-IV_BCG_PLS-DA_Statistics.docx
Data files: A.LMX-samples-publish2022-01-27_23-59.xlsx, D.FILE-220127ALT-1_Data_EI_IV_BCG_IgM_SystemsSe..., D.FILE-samples-publish2022-01-28_00-04.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.ALT-211119-V1_Mac-Live-Dead-Protocol-EI.docx, P.ALT-211119-V1_Mac-Lux-Opsonize-Protocol-EI.docx, P.ALT-211119-V1_Mac-Lux-Protocol-EI.docx
Data files: No Data files
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.ALT-211020-V1_LAM-ADCP-Protocol-EI.doc, P.ALT-211020-V1_LAM-ADNP-Protocol-EI.doc, P.ALT-211101-V1_LAM-ADNKA-Protocol-EI.doc
Data files: No Data files
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: No SOPs
Data files: MUS-samples-publish2022-03-15_01-19.xlsx, TIS-samples-publish2022-03-15_01-23.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: No SOPs
Data files: D.SEQ-samples-publish2022-03-25_04-01.xlsx
Snapshots: No snapshots
Submitter: Dikshant Pradhan
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: No SOPs
Data files: A.SCCLUST-samples-publish2022-04-08_05-10.xlsx, A.SCEXPR-samples-publish2022-04-08_05-07.xlsx
Snapshots: No snapshots
Submitter: Jake Schissel
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.FLY-220823-V1_P---Mtb-Infection.rtf, P.FLY-220823-V1_P---NHP_housing.docx, P.FLY-220823-V1_P---Necropsy.docx, P.FLY-220823-V1_P---PET_CT_Imaging.docx
Data files: NHP-samples-publish2022-09-28_17-30.xlsx, PAV-samples-publish2022-11-3_15-09.xlsx
Snapshots: No snapshots
Submitter: Jake Schissel
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.FLY-220823-V1_P---Bacteria-Burden.docx, P.FLY-220823-V1_P---Chromosomal-Equivalents.rtf, P.FLY-220823-V1_P---Necropsy.docx
Data files: PAV-samples-publish2022-11-3_15-09.xlsx, TIS-samples-publish2022-10-11_23-37.xlsx
Snapshots: No snapshots
Submitter: Jake Schissel
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.FLY-210708-V1_Hannah's-GentleMacs-Protocol-as..., P.SHA-220819-V1_SeqWellHughes.et.al.Master.Prot...
Data files: DNA-samples-publish2022-10-18_00-56.xlsx, TIS-samples-publish2022-10-11_23-37.xlsx
Snapshots: No snapshots
Submitter: Jake Schissel
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.SHA-220819-V1_SeqWellHughes.et.al.Master.Prot...
Data files: D.SEQ-samples-publish2022-10-25_19-32.xlsx, DNA-samples-publish2022-10-18_00-56.xlsx
Snapshots: No snapshots
Submitter: Jake Schissel
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.SHA-220912-V1_Drop-seq_Alignment_Cookbook.pdf
Data files: A.SCXP-samples-publish2022-10-25_21-23.xlsx, D.SEQ-samples-publish2022-10-25_19-32.xlsx
Snapshots: No snapshots
Submitter: Jake Schissel
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.SHA-220824-V1_P---Clustering.docx
Data files: A.SCCL-samples-publish2022-10-28_13-03.xlsx, A.SCXP-samples-publish2022-10-25_21-23.xlsx
Snapshots: No snapshots
Submitter: Jake Schissel
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.FLY-220824-V1_P---Immunohistochemistry-Analys...
Data files: AB-samples-publish2022-10-28_14-18.xlsx, ABP-samples-publish2022-10-28_14-25.xlsx, D.IMG-samples-publish2022-10-28_14-40.xlsx, samples-publish2023-03-21_22-232.xlsx
Snapshots: No snapshots
Submitter: Jake Schissel
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.FLY-220823-V1_P---PET_CT_Imaging.docx
Data files: D.IMG-samples-publish2022-10-28_13-10.xlsx, PAV-samples-publish2022-11-3_15-09.xlsx
Snapshots: No snapshots
Submitter: Jake Schissel
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.FLY-220823-V1_P---PET_CT_Imaging.docx
Data files: A.CTSC-samples-publish2022-10-28_13-14.xlsx, D.IMG-samples-publish2022-10-28_13-10.xlsx
Snapshots: No snapshots
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.BOO-230324-V1_KC_Protocol
Data files: PAT-samples-publish2023-05-17_13-17.xlsx, PAV-samples-publish2023-05-17_13-27.xlsx
Snapshots: No snapshots
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.BOO-230324-V1_KC_Protocol
Data files: PAV-samples-publish2023-05-17_13-27.xlsx, TIS-samples-publish2023-05-17_15-05.xlsx
Snapshots: No snapshots
Submitter: Charles Demurjian
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: IMPAcTB
Organisms: No organisms
SOPs: P.SES-230405-V1_JP_Flow_Protocol.docx
Data files: AB-samples-publish2023-05-17_15-29.xlsx, ABP-samples-publish2023-05-17_15-30.xlsx, D.FCS-samples-publish2023-05-17_15-19.xlsx, D.FLOW-samples-publish2023-05-17_15-16.xlsx, TIS-samples-publish2023-05-17_15-05.xlsx
Snapshots: No snapshots
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Flow Cytometry – Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Flow Cytometry Processing – Data Attached, Flow Cytometry – Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: T cell signatures of bacterial control among M....
Assays: Flow Cytometry - Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: T cell signatures of bacterial control among M....
Assays: Flow Cytometry - Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: T cell signatures of bacterial control among M....
Assays: Flow Cytometry - Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: T cell signatures of bacterial control among M....
Assays: Flow Cytometry - Data Linked, Flow Cytometry Analysis - Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: T cell signatures of bacterial control among M....
Assays: Flow Cytometry - Data Linked, Tissue Collection - Metadata
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: T cell signatures of bacterial control among M....
Assays: Patient Visit - Metadata
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: T cell signatures of bacterial control among M....
Assays: Patient Visit - Metadata, Tissue Collection - Metadata
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Flow Cytometry – Data Linked
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Flow Cytometry – Data Linked
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: IMPAcTB
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Flow Cytometry – Data Linked, Tissue Collection - Metadata
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Patient Visit – Metadata, Tissue Collection - Metadata
Batch sample publishing
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Patient Visit – Metadata
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Creators: None
Submitter: Jake Schissel
Investigations: IMPAcTB
Studies: Multimodal profiling of lung granulomas in maca...
Assays: NHP Necropsy – Metadata, PET-CT Scan – Data Linked, Patient Visit – Metadata
Batch sample publishing
Creators: None
Submitter: Jake Schissel
Investigations: IMPAcTB
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: T cell signatures of bacterial control among M....
Assays: Flow Cytometry - Data Linked
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: T cell signatures of bacterial control among M....
Assays: Patient Visit - Metadata, Tissue Collection - Metadata
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Patient Visit – Metadata, Tissue Collection - Metadata
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Patient Visit – Metadata, Tissue Collection - Metadata
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Patient Visit – Metadata, Tissue Collection - Metadata
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Patient Visit – Metadata, Tissue Collection - Metadata
Creator: Charles Demurjian
Submitter: Charles Demurjian
Investigations: IMPAcTB
Studies: Immune cells in bronchoalveolar lavage fluid of...
Assays: Patient Visit – Metadata, Tissue Collection - Metadata
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Studies: Multimodal profiling of lung granulomas in maca...
Assays: Library Creation – Metadata, Single Cell Sequencing – Data Linked
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Studies: Multimodal profiling of lung granulomas in maca...
Assays: Library Creation – Metadata
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Studies: Multimodal profiling of lung granulomas in maca...
Assays: NHP Necropsy – Metadata
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Studies: Multimodal profiling of lung granulomas in maca...
Assays: NHP Necropsy – Metadata
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Studies: Multimodal profiling of lung granulomas in maca...
Assays: PET-CT Scan Analysis – Data Linked, PET-CT Scan – Data Linked, Patient Visit – Metadata
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Studies: Multimodal profiling of lung granulomas in maca...
Assays: Patient Visit – Metadata
Creator: Jake Schissel
Submitter: Jake Schissel
Investigations: IMPAcTB
Studies: Multimodal profiling of lung granulomas in maca...
Assays: Patient Visit – Metadata
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: IMPAcTB
Studies: Robust IgM responses following intravenous vacc...
Assays: Functional Assay – Metadata
Creator: Dikshant Pradhan
Submitter: Dikshant Pradhan
Investigations: IMPAcTB
Studies: Robust IgM responses following intravenous vacc...
Assays: Functional Assay – Metadata