Projects

Coastal zones and oceans constitute an essential fundament for Norway’s history as well as current economy, providing ecosystem services for fisheries, aquaculture, transport, tourism, and recreation. The petroleum activities in Norwegian waters have been crucial for Norway’s financial growth and in financing the Norwegian welfare state. As the pressure on the oceans continuously increases, both the petroleum industry and the seafood industries have acknowledged that awareness and actions are ...

Silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation

From thermodynamics through kinetics and non equilibrium thermodynamics to control analysis

Chapter on non equilibrium thermodynamics. The chapter discusses both phenomenological and mechanistic non equilibrium thermodynamics. The phenomenological part has as asset compared to earlier treatments that it also considers the phenomenological stoichiometry as a parameter that may be adjusted by systems to attain optimal performance. In the mechanistic part, this feature of variable stoichiometry and 'slips' as well as redistribution of fluxes over parallel branches of metabolism is discussed. ...

A chapter on generalized thermodynamics. The chapter is not specifically about biology although it uses many examples in biology due to the richness of the topic. It deals with the first and second law of thermodynamics, catalysts, and engines. This includes heat engines, heat pumps, and protonmotive ATP synthase.

Most systems biology deals with Life as we know it on this planet (Earth). This project will focus on how (nonsynthetic) Life may differ from mainstream Life. The ultimate focus thereby rests on extraterrestrial Life, but for lack of definitive evidence of this, the project studies Life found under conditions that may be similar to extraterrestrial conditions enabling Life. The focus is herewith on the systems biology in remote environments on Earth. The project deals both with the systems cell ...

Investigation 1: An experimental workflow to provide detailed information of the molecular mechanisms of enzymes is described. This workflow will help in the application of enzymes in technical processes by providing crucial parameters needed to plan, model and implement biocatalytic processes more efficiently. These parameters are homogeneity of the enzyme sample (HES), kinetic and thermodynamic parameters of enzyme kinetics and binding of reactants to enzymes. The techniques used to measure ...

The purpose of this project is to exchange public and private research data that is not attached to "normal" projects together with SDBV via the FAIRDOMHub.

to test the api

The main goal of this project is to create a null-CO2 foot-printing and robust biotechnological platform based on microbial consortia to produce sustainable bio-based compounds using CO2 and light as the sole sources of carbon and energy, respectively.

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Sustainable co-production is the short form of the research project “Tobacco as sustainable production platform of the natural biopolymer cyanophycin as co-product to oil and protein”. It combines plant and industrial biotechnology to increase the value of commercially grown tobacco with products that can sustainably substitute fossil raw materials. We aim to establish a new economically feasible production system for the biopolymer cyanophycin (CGP) as a by-product of tobacco without relevant ...

BioCreative VII

Our world is changing fast! Key global trends are rapid urbanisation, growing and ageing populations, and increased prosperity. This results in depletion of natural and petrochemical resources and climate change, which affects the quality of the environment and people's lives. Therefore, developing a bio-based economy is key to sustain our planet in the long term. Raw materials will have to be recruited from renewable sources.

Industrial biotechnology is potentially a very powerful technology in ...

CEPOPA envisions a sustainable cascade one-pot process for the synthesis of optically pure amines from alcohols and/or alkynes, using enzymes immobilized onto catalytically active nanomaterials. In the framework of the project, efficient chemoenzymatic processes will be developed for the synthesis of a set of amines that can be used as building blocks for pharmaceuticals or biomaterials.

Most biological processes require energy and are tightly regulated. Energy is extracted from food supplies and eventually transformed into ATP, the universal energy carrier of the cell. These pathways consist of many reactions which involve NAD or NADP, small molecules which serve as intermediate energy transmitters. Vitamin B3 is essential for the synthesis of these nucleotides. Interestingly, the key molecules in energy transduction also have important roles in the regulation of all vital ...

to complete

This project’s main objective was to identify novel Colorado potato beetle gene targets for the development of specific RNAi insecticides and further validate prospective targets using transcriptomics. The work included gene selection, establishment of double-stranded RNA (dsRNA) production methodology and the evaluation of dsRNAs’ insecticidal potential in CPB feeding laboratory and field trials.

The New Medicines for Trypanosomatidic Infections - NMTrypI project aimed at obtaining new candidate drugs against Trypanosomatidic infections with appropriate efficiency from the lead phase to the final preclinical phase that are more accessible to patients.

In the CoVIDD project, we aim at unravelling interactions of viral proteins with the cellular factors and the host pathways involved in SARS-CoV-2 infection by a combination of modern technologies, genomics, proteomics, structural biology, chemoinformatics and drug discovery. To effectively search for drugs that could modify viral replication we need to know what human proteins and viral proteins interact. Thus, a comprehensive virus-host protein interaction network will help us to identify the ...