Projects

EPSRC project with Exeter, SynthSys and EPCC

EU FP7 collaborative project TiMet, award number 245143. Funded 2010-2015. "TiMet assembles world leaders in experimental and theoretical plant systems biology to advance understanding of the regulatory interactions between the circadian clock and plant metabolism, and their emergent effects on whole-plant growth and productivity."

Public showcase and collection of training material

Pesticides, plastics, cosmetics, electrical transformers and many other products contain Endocrine disruptors (EDCs). EDCs interfere with natural hormone functions and may cause the disease.

WURSynBio

Escherichia coli is a well-established and the most widely used organism for the production of recombinant proteins (used in medical and industrial applications, as molecular biology reagents, etc.). Production of proteins is the most resource exhaustive process for the cells and therefore needs to be optimized to achieve maximal productivities. Natural environment of E. coli is much harsher compared to the near optimal growth conditions used in production processes. In order to survive cells ...

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CropClock - Increasing Crops Biomass by Uncovering the Circadian Clock Network Using Dynamical Models

The circadian clock is an internal timing system that allows plants to predict daily and seasonal changes in light and temperature and thus to adapt photosynthesis, growth, and development to external conditions. The core oscillator is well understood in the model plant Arabidopsis, however, relatively little is known about the dynamic effects of the clock on agronomic behaviour of crop plants. ...

Cystic Fibrosis (CF)- lethal autosomic disease CFTR - Cystic Fibrosis Transmembrane Regulator

We are modelling ROS management and mitochondrial dysfunction. Mitochondria produce both energy and reactive oxygen species (ROS), and suffer from ROS. Experimental data from University Milan-Bicocca.

This project provides a space for storing, annotating and publishing Systo models.

Within the e:Bio - Innovationswettbewerb Systembiologie (Federal Ministry of Education and Research (BMBF)), the SulfoSYSBIOTECH consortium (10 partners), aim to unravel the complexity and regulation of the carbon metabolic network of the thermoacidophilic archaeon Sulfolobus solfataricus (optimal growth at 80°C and pH 3) in order to provide new catalysts ‘extremozymes’ for utilization in White Biotechnology.

Based on the available S. solfataricus genome scale metabolic model (Ulas et al., 2012) ...

GMO free systems optimization of wine yeast for wine production by massive scale directed evolution

Designer microbial communities for fermented milk products: A Systems Biology Approach

ErasysApp Funders

Systems biology of bacterial methylotrophy for biotechnological

Comparative Systems Biology: Lactic Acid Bacteria

BaCell-SysMO 2 Modelling carbon core metabolism in Bacillus subtilis – Exploring the contribution of protein complexes in core carbon and nitrogen metabolism.

Bacillus subtilis is a prime model organism for systems biology approaches because it is one of the most advanced models for functional genomics. Furthermore, comprehensive information on cell and molecular biology, physiology and genetics is available and the European Bacillus community (BACELL) has a well-established reputation for applying ...

Systems Biology of Clostridium acetobutylicum - a possible answer to dwindling crude oil reserves

"Systems Understanding of Microbial Oxygen responses" (SUMO) investigates how Escherichia coli senses oxygen, or the associated changes in oxidation/reduction balance, via the Fnr and ArcA proteins, how these systems interact with other regulatory systems, and how the redox response of an E. coli population is generated from the responses of single cells. There are five sub-projects to determine system properties and behaviour and three sub-projects to employ different and complementary modelling ...