RNA Systems Biology Lab

The RNA Systems Biology Lab Programme compiles the different research projects developed in our lab. The RNA Systems Biology Lab is a collaborative research lab headed by PIs Margarida Gama-Carvalho and Francisco Pinto at the Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, and integrates the BioSystems and Integrative Sciences Institute (BioISI) Gene Expression and Regulation Group, headed by Margarida Gama-Carvalho. Our research brings together computational and laboratory approaches to characterize and model regulatory networks involved in the coordination of gene expression programs in vertebrates. We are particularly interested in regulatory events occurring at the post-transcriptional level involving small non-coding RNAs and the interaction of RNA binding proteins with mRNA untranslated sequence elements (UTRs). Our expanded interests further include the development of integrative data analysis and next generation sequencing technologies - in particular RNA-seq and nanopore seq - for biomedical applications including biomarker identification, genetic profiling and precision medicine.