This project aims to characterise the mechanisms through which microRNAs and small non-coding RNAs act to regulate cellular processes focusing on Naïve CD4 T cell activation and viral replication - namely HIV - and to explore their potential use as a therapeutic co-adjuvant agents or targets.
Programme: RNA Systems Biology Lab
SEEK ID: https://fairdomhub.org/projects/162
Funding codes:- PTDC/BIA-CEL/29257/2017
- Merck IISP-39114
Public web page: Not specified
Organisms: Homo sapiens
FAIRDOM PALs: No PALs for this Project
Project start date: 5th Nov 2019
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Projects: CF transcriptome, miRiAD - exploring the role of microRNAs in T cell function and anti-viral defence, ComPASs - Common Pathways in Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), LungCARD - Blood test for clinical therapy guidance of non-small cell lung cancer patients, UnCentre - Unlocking satellite DNA and centromere structure in vertebrate chromosomes, PhotoBoost
Institutions: RNA Systems Biology Lab - BioISI/FCUL, Instituto de Tecnologia Química e Biológia - Universidade Nova de Lisboa
Group Leader and Assistant Professor
Projects: ComPASs - Common Pathways in Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), miRiAD - exploring the role of microRNAs in T cell function and anti-viral defence, LungCARD - Blood test for clinical therapy guidance of non-small cell lung cancer patients
Institutions: RNA Systems Biology Lab - BioISI/FCUL
Expertise: Bioinformatics, Systems Biology
Projects: ComPASs - Common Pathways in Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), miRiAD - exploring the role of microRNAs in T cell function and anti-viral defence, LungCARD - Blood test for clinical therapy guidance of non-small cell lung cancer patients, Mapping Disease Modules Overlaps in Biological Networks
Institutions: RNA Systems Biology Lab - BioISI/FCUL
https://orcid.org/0000-0002-4217-0054The RNA Systems Biology Lab Programme compiles the different research projects developed in our lab. The RNA Systems Biology Lab is a collaborative research lab headed by PIs Margarida Gama-Carvalho and Francisco Pinto at the Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, and integrates the BioSystems and Integrative Sciences Institute (BioISI) Gene Expression and Regulation Group, headed by Margarida Gama-Carvalho. Our research brings together computational ...
Projects: CF transcriptome, miRiAD - exploring the role of microRNAs in T cell function and anti-viral defence, ComPASs - Common Pathways in Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), LungCARD - Blood test for clinical therapy guidance of non-small cell lung cancer patients, UnCentre - Unlocking satellite DNA and centromere structure in vertebrate chromosomes, Mapping Disease Modules Overlaps in Biological Networks
Web page: Not specified
Abstract (Expand)
Authors: Meredith Hill, Dayna Mason, Tânia Monteiro Marques, Margarida Gama Carvalho, Nham Tran
Date Published: 1st Oct 2019
Publication Type: Not specified
DOI: 10.1016/j.mex.2019.10.011
Citation: MethodsX
Abstract (Expand)
Authors: D. Mason, X. Zhang, T. M. Marques, B. Rose, S. Khoury, M. Hill, F. Deutsch, J. G. Lyons, M. Gama-Carvalho, N. Tran
Date Published: 24th Jun 2018
Publication Type: Not specified
PubMed ID: 29935424
Citation: Virology. 2018 Aug;521:149-157. doi: 10.1016/j.virol.2018.05.022. Epub 2018 Jun 20.
Abstract (Expand)
Authors: A. J. Amaral, J. Andrade, R. B. Foxall, P. Matoso, A. M. Matos, R. S. Soares, C. Rocha, C. G. Ramos, R. Tendeiro, A. Serra-Caetano, J. A. Guerra-Assuncao, M. Santa-Marta, J. Goncalves, M. Gama-Carvalho, A. E. Sousa
Date Published: 1st Feb 2017
Publication Type: Not specified
PubMed ID: 27993935
Citation: EMBO J. 2017 Feb 1;36(3):346-360. doi: 10.15252/embj.201694335. Epub 2016 Dec 19.