Human papillomavirus 16 E6 modulates the expression of miR-496 in oropharyngeal cancer.


Human papillomavirus (HPV), notably type 16, is a risk factor for up to 75% of oropharyngeal squamous cell carcinomas (SCC). It has been demonstrated that small non-coding RNAs known as microRNAs play a vital role in the cellular transformation process. In this study, we used an LNA array to further investigate the impact of HPV16 on the expression of microRNAs in oropharyngeal (tonsillar) cancer. A number of miRNAs were found to be deregulated, with miR-496 showing a four-fold decrease. Over-expression of the high risk E6 oncoprotein down-regulated miR-496, impacting upon the post-transcriptional control of the transcription factor E2F2. These HPV specific miRNAs were integrated with the HPV16 interactome to identify possible mechanistic pathways. These analyses provide insights into novel molecular interactions between HPV16 and miRNAs in oropharyngeal cancers.


PubMed ID: 29935424

Projects: miRiAD - exploring the role of microRNAs in T cell function and anti-vir...

Publication type: Not specified

Journal: Virology

Citation: Virology. 2018 Aug;521:149-157. doi: 10.1016/j.virol.2018.05.022. Epub 2018 Jun 20.

Date Published: 24th Jun 2018

Registered Mode: Not specified

Authors: D. Mason, X. Zhang, T. M. Marques, B. Rose, S. Khoury, M. Hill, F. Deutsch, J. G. Lyons, M. Gama-Carvalho, N. Tran


Views: 741

Created: 5th Nov 2019 at 13:30

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