AIRC

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Medulloblastoma represents the most frequent malignant brain tumor in children, occurring in the cerebellum. At diagnosis, approximately 30% of patients show disseminated (metastatic) disease. Approximately 60% survival can be reached with multimodal treatment including operation, irradiation and chemotherapy. However, survivors suffer from significant side effects, including neurocognitive impairment, which is very severe in young age when the central nervous system is still developing. To reduce ...

Produktion von Ethylacetat aus Molkerückständen mit Kluyveromyces marxianus und Produktgewinnung mittels Membranverfahren

MS-Proteomics and Lipidomics raw data associate with the present research paper

MS-Proteomics raw data repository

The group around Nicole Radde specializes in the modeling, analysis, and simulation of biochemical systems. This especially includes parameter optimization and identification.

A pilot project to evaluate FAIR data practices for tropical perennial crops. Focuses on characterizing genetic diversity and environmental resilience.

tomato project

Test project

Komplexe, erweiterte Leberresektionen ((e)PHx) stellen ein hohes Risiko für ein postoperatives Leberversagen dar, insbesondere bei einer bereits bestehenden Lebererkrankung. Das Ziel von QuaLiPerF ist es, bisher unbekannte Wechselwirkungen zwischen den durch die Operation verursachten Veränderungen der Perfusion und der Stoffwechselfunktion aufzuklären. Wir werden einen systemmedizinischen Ansatz anwenden, um ein mehrskaliges Modell der Leberperfusion und -funktion zu erstellen, das die Vorhersage ...

This is a sandbox where DigiSal members can learn to use the SEEK.

Tutorial document: http://tinyurl.com/seek-ds17

The SEEK is a web interface to a database of research "assets" organised in a hierarchical "ISA structure" (investigation-study-assay) [1]. These are further organised into projects and programmes.

• Programme = Overarching research theme (The Digital Salmon)
• Project = Research grant (DigiSal, GenoSysFat)
• Investigation = a particular biological process, phenomenon or thing ...

Salmon farmed on modern feeds contains less of the healthy, long-chain fatty acids (EPA and DHA) than before. Up until the turn of the millennium, farmed salmon were fed fish oil as a replacement for their omega-3 rich natural prey. However, fish oil is now a scarce resource, and more than half of the fat in modern feeds comes from plant oils that are inexpensive, but devoid of long-chain omega-3 fatty acids. How can we increase the omega-3 content of salmon on sustainable feeds?

One option is ...

Towards the Digital Salmon: From a reactive to a pre-emptive research strategy in aquaculture (DigiSal)

Salmon farming in the future must navigate conflicting and shifting demands of sustainability, shifting feed prices, disease, and product quality. The industry needs to develop a flexible, integrated basis of knowledge for rapid response to new challenges. Project DigiSal will lay the foundations for a Digital Salmon: an ensemble of mathematical descriptions of salmon physiology, combining ...

A fundamental and enduring challenge for ecosystem managers developing risk and impact assessment tools is to predict the extent of impact that spilled oil can have on the immediate fish populations and on future generations. Modelling approaches are important tools for these assessments, but they currently suffer from two major shortcomings: 1) the failure to acknowledge that effects can be transferred through several generations and 2) the assumption that a small group of toxic compounds, ...

HubMOL is a Marie Skłodowska-Curie Actions Doctoral Network funded by Horizon Europe.

The hub molecules of life comprise a set of cofactors that are crucial for all cellular functions. They are well known for their central roles in both metabolism and signalling. Still, our limited knowledge of the crosstalk and the reciprocal connectivity between key metabolic and signal transduction pathways and the dynamic interplay of hub molecules is currently hampering their exploitation. Imbalances in hub ...

This project collects summary information and (visual) characterizations of lung health related polygenic scores and underlying GWAS, based on publicly available data.

As a scientists-founded and scientists-driven leading biotechnological company, Creative Biogene focuses on developing high quality products and services, as well as proprietary technology to support the research in the field of basic life sciences research, biomedical development, industrial synthetic application and preclinical drug discovery.

This project provides datasets supporting the analysis of carbon partitioning and metabolite excretion in different Synechocystis sp. PCC 6803 strains. It includes intracellular and extracellular metabolite measurements, glycogen quantification, and sampling metadata, enabling investigation of carbon overflow and glycogen metabolism under different nitrogen conditions.

Research Training Group 2901 SYLOBIO

Systemic and local reactions in case of incompatibility to biomaterials for joint and skin lesions

Incompatibility to biomaterials and the body's response

Biomaterials serve as temporary or permanent replacements for tissue structures that are irreversibly damaged or functionally impaired. Possible incompatibility of biomaterials used for total joint replacements and dressings for chronic wounds is triggered by inflammatory reactions in the host tissue, ...

Model-based design of a biorefinery platform to valorise agrifood organic waste into odd-chain volatile fatty acids integrating technical and environmental criteria

The conversion of organic wastes by anaerobic fermentation (the so-called carboxylate platform) is one of the promising emerging biorefineries that allows valorising organic carbon to volatile fatty acids (VFA), which can be further processed as chemicals, biopolymers and biofuels. A major obstacle to the widespread of the carboxylate ...

Understanding the spectrum of complex metastatic processes is important to the development of a comprehensive and cohesive understanding of cancer metastasis. The Metastasis Research Network (MetNet) supports collaborative, multidisciplinary projects that focus on several themes of the metastatic process and use integrative systems-level approaches.

MetNet is advancing the understanding of metastasis as a non-linear, dynamic, and emergent process, as well as revealing mechanistic insights of early ...