Projects

The goal of the project is to establish a new biotechnological platform for the production of hydroxy-amino acids, since the current production of these important building blocks is very expensive. Enzyme engineering, systems biotechnology and metabolic engineering will be used in a synthetic biology approach.

We used the Neo4j graph database approach to integrate the content of the COVID-19 Disease Map diagrams to efficiently access, query and manage the content of these diagrams and enable communication with external resources, such as Reactome and Recon, that already provide support via a similar environment. This work complements the efforts on exploring COVID-19 disease mechanisms within the COVID-19 Disease Map Project.

Just a test

This is a project for testing

BIODYNAMICS approach will aim to demonstrate that multipurpose microbial cell factories based on a standardized, modular plug-andplay synthetic biology pipeline are a real possibility for quicker, cheaper and more effective bioproduction. To this end, we will develop novel hybrid (data-driven and mechanistic) modelling and characterization methods and tools for advanced metabolic engineering biology. In particular, it will consider the design, implementation and analysis of optimal synthetic ...

LEADER: StU (prof. B. Klumperman)

PARTNERS: StU & SU

OBJECTIVES:

• Optimization of antimalarial drug encapsulation for fast release.

• Development of transmission blocking drug encapsulation for slow release.

DELIVERABLES:

**07.2022 D ...

LEADER: prof. L-M. Birkholtz

PARTNERS: UP & WITS & SU & StU

OBJECTIVES:

• Evaluation of the ability of the novel polymer-drug systems to kill the transmissible gametocytes.

• Validation using treatment of anopheline mosquitoes in a membrane feeding assay.

...

A project for the Digital Salmon use case in BT8121 - Transdisciplinary biotechnology - a Digital Life Norway course.

WARNING: THIS IS A TEST PROJECT CREATED FOR TESTING THE UPLOAD TO FAIRDOMHUB USING seekr AND SEEK API

pISA-tree: Standard project directory tree

A set of batch files is used to create standard directory tree for research projects. Batch files are provided to make standardized nested directories in accordance with the ISA Abstract Model levels (Investigation/Study/Assay).

https://github.com/NIB-SI/pISA-tree

https://bio.tools/pisa-tree

Linked resources:

• R support for pISA-tree DOI ...

LEADER: UL (prof. J.C. Simon)

PARTNERS: UL & IPF & SU & StU

OBJECTIVES:

• Validation of biocompatibility of the drug delivery systems with the skin.

• Testing of the drug delivery into and through the skin.

DELIVERABLES ...

BBSRC sLoLa grantThe spread of antimicrobial resistance (AMR) is a slow-moving pandemic that has been identified by the WHO as one of the top 10 threats facing humanity. Plasmids and other MGEs play a key role in the dissemination of AMR, but we have only a rudimentary understanding of the factors that determine if and how MGEs spread through microbial communities. It is generally assumed that bacterial immune systems are a major determinant, but existing studies are limited to only a few stand-alone ...

The project brings comprehensive study of diversity in Clostridium beijerinckii, solvent-producing species with potential use in industrial biotechnology.

Andrew Millar's research group, University of Edinburgh

Rationale: Individuals with a cancer predisposition due to a mutation in the paradigm tumor suppressor gene RB1, have a high risk to develop the childhood cancer retinoblastoma (Rb). Biopsies are not possible in Rb, before treatment selection. Heritable Rb patients have also a high risk to develop other types of second primary, either childhood or adult, malignancies (SPMs), notably sarcomas and melanomas. Remarkably, SPMs are now the leading cause of death in heritable-Rb-survivors. Unfortunately, ...

LEADER: IPF (prof. A. Lederer)

PARTNERS: IPF & StU

OBJECTIVES:

• Determination of stability, degradation and drug release kinetics.

• Mathematical modelling of response to treatments of infectious diseases.

DELIVERABLES

10.2022 M 3.1 ...

Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.

Investigation regarding the impact of periportal steatosis on selected parameters of drug metabolism.