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OverviewGlobal metabolic switching in Streptomyces coelicolor
Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.
Programme: SysMO
SEEK ID: https://fairdomhub.org/projects/10
Public web page: Not specified
Organisms: Streptomyces coelicolor
FAIRDOM PALs: Walid Omara, Jay Moore
Project created: 15th Jan 2009
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The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.
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Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.
One of these activities is antibiotic production and is widespread in streptomycetes ...
Submitter: Jay Moore
Studies: ScoCyc metabolic pathway curation, Timeseries 1
Assays: Metabolic pathway curation, Online/offline measurements, metabolomics, proteomics, transcriptomics
Submitter: Jay Moore
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Assays: Metabolic pathway curation
Genotype: Wildtype (M145E) Medium: Phosphate-limited (F134)
Submitter: Jay Moore
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Assays: Online/offline measurements, metabolomics, proteomics, transcriptomics
Submitter: Jay Moore
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Study: Timeseries 1
Submitter: Jay Moore
Assay type: Transcriptomics
Technology type: Custom Array
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Study: Timeseries 1
Submitter: Jay Moore
Assay type: Metabolite Profiling
Technology type: Gas Chromatography Mass Spectrometry
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Study: Timeseries 1
Submitter: Jay Moore
Assay type: Proteomics
Technology type: Gas Chromatography Mass Spectrometry
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Study: Timeseries 1
Submitter: Jay Moore
Biological problem addressed: Metabolic Network
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Creators: Trond Ellingsen, Øyvind Jakobsen, Per Bruheim, Håvard Sletta, Anders Øverby, Sven Even Borgos, Sunniva Hoel, Alexander Wentzel
Submitter: Jay Moore
Creators: David Rand, R Jansen, Maria Elena Merlo, Morris Swertz, Preben Krabben, Kay Nieselt, Wolfgang Wohlleben, Jens Reuther, David Hodgson, Anthony Palathingal, David Wild, Elizabeth Wellington, Gregory Challis, Nigel Burroughs, Walid Omara, William Gaze, Brent Kiernan, Roxane Legaie, Sunniva Hoel, Juan-Francisco Martin, Antonio Rodríguez-García, Trond Ellingsen, Øyvind Jakobsen, Per Bruheim, Håvard Sletta, Anders Øverby, Sven Even Borgos, Jay Moore, Alexander Wentzel, Maggie Smith, Louise Thomas, Eriko Takano, Lubbert Dijkhuizen, Rainer Breitling, M. Tauqeer Alam
Submitter: Jay Moore
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Creators: Jay Moore, David Hodgson
Submitter: Jay Moore
Creators: Jay Moore, David Hodgson
Submitter: Jay Moore
Creators: Jay Moore, David Hodgson, Veronica Armendarez, Emma Laing , Govind Chandra, Mervyn Bibb
Submitter: Jay Moore
Model type: Metabolic network
Model format: BioPAX
Environment: Not specified
Creators: Trond Ellingsen, Øyvind Jakobsen, Per Bruheim, Håvard Sletta, Anders Øverby, Sven Even Borgos, Sunniva Hoel, Alexander Wentzel
Submitter: Jay Moore
Creators: Trond Ellingsen, Øyvind Jakobsen, Per Bruheim, Håvard Sletta, Anders Øverby, Sven Even Borgos, Sunniva Hoel, Alexander Wentzel
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Creators: Louise Thomas, Maggie Smith
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Submitter: Jay Moore
Creators: Louise Thomas, Maggie Smith
Submitter: Jay Moore
Creators: Louise Thomas, Maggie Smith
Submitter: Jay Moore
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Creators: Per Bruheim, Trond Ellingsen, Sunniva Hoel, Øyvind Jakobsen, Håvard Sletta, Alexander Wentzel, Anders Øverby, Strøm, A
Submitter: Jay Moore
Creators: Per Bruheim, Trond Ellingsen, Sunniva Hoel, Øyvind Jakobsen, Håvard Sletta, Alexander Wentzel, Anders Øverby, Strøm, A
Submitter: Jay Moore
Creators: Per Bruheim, Trond Ellingsen, Sunniva Hoel, Øyvind Jakobsen, Håvard Sletta, Alexander Wentzel, Anders Øverby, Strøm, A
Submitter: Jay Moore
Creators: Per Bruheim, Trond Ellingsen, Sunniva Hoel, Øyvind Jakobsen, Håvard Sletta, Alexander Wentzel, Anders Øverby, Strøm, A
Submitter: Jay Moore
Creators: Per Bruheim, Trond Ellingsen, Sunniva Hoel, Øyvind Jakobsen, Håvard Sletta, Alexander Wentzel, Anders Øverby, Strøm, A
Submitter: Jay Moore
Creators: Per Bruheim, Trond Ellingsen, Sunniva Hoel, Øyvind Jakobsen, Håvard Sletta, Alexander Wentzel, Anders Øverby, Strøm, A
Submitter: Jay Moore
Creators: Per Bruheim, Trond Ellingsen, Sunniva Hoel, Øyvind Jakobsen, Håvard Sletta, Alexander Wentzel, Anders Øverby, Strøm, A
Submitter: Jay Moore
Abstract (Expand)
Authors: A. Wentzel, P. Bruheim, A. Overby, O. M. Jakobsen, H. Sletta, W. A. Omara, D. A. Hodgson, T. E. Ellingsen
Date Published: 9th Jun 2012
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Abstract (Expand)
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Date Published: 13th Mar 2012
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Abstract (Expand)
Authors: A. Wentzel, H. Sletta, T. E. Ellingsen, P. Bruheim
Date Published: 2012
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Abstract (Expand)
Authors: L. Thomas, D. A. Hodgson, A. Wentzel, K. Nieselt, T. E. Ellingsen, J. Moore, E. R. Morrissey, R. Legaie, W. Wohlleben, A. Rodriguez-Garcia, J. F. Martin, N. J. Burroughs, E. M. Wellington, M. C. Smith
Date Published: 8th Dec 2011
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Abstract (Expand)
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