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I am postdoc in the group of Prof Ian Booth in Aberdeen working on the biochemical and biophysical characterisation of bacterial channels.
My background is physics engineering & biomedical engineering. I did my PhD in Surrey on the modelling of response of mammalian cells to radiation of different qualities.
I have been working at the University of Aberdeen since November 2007 as a theoreticien research fellow of the KOSMOBAC project. We are investigating the homeostasis of ions in bacteria E. coli. I have been working at a model of the buffering capacity of the cytopplasm, arising from the presence of weak acids and bases. We have
I am final year PhD student in Prof Ian Booth's lab and a microbiologist by trade. I am interested in how enteric bacteria cope with stress and what systems they employ to increase their chances of survival, in particular upon methylglyoxal stress.
Tools: Chemical cross-linking, Site-directed mutagenesis, Membrane protein biochemistry, Biochemistry of substrate transport. molecular biological techniques (RNA/DNA techniques analyses of transport across cell membranes heterologous e..., Molecular Biology, Microbiology
I am a biologist by training. My research career is focussed on the structure-function relationships of membrane transport systems in Escherichia coli. I am interested in understanding the mechanism of ion and solute transport across the membrane and how this influences bacterial cell survival. My work mainly focusses on the ligand-gated potassium efflux systems which are crucial for cell survival during electrophile exposure and the mechanosensitive channels involved in hypoosmotic stress
My research interests are in the physiology of bacteria subjected to stress. The focus of my recent research has been the structure and function of regulated transport systems and ion channels involved in cellular homeostasis. These transporters and channels respond to specific signals by a change in activity that either corrects the imposed stress or protects the cell during exposure to the stress. Our systems biology interests are in the interplay of different enzymes systems and transporters
Tools: Deterministic models, including:- Dynamic modelling- Parameter estimation- Optimal experimental design- Dynamic optimization, Computational Systems Biology, Stochastic models, C programming, enzymatic analyses, data modeling, linux, ODE, Computational and theoretical biology
Global metabolic switching in Streptomyces coelicolor
Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.