Projects: Not specified
Institutions: Not specifiedhttps://orcid.org/0000-0002-8363-0678
Projects: Systems toxicology of Atlantic cod
Institutions: University of Bergenhttps://orcid.org/0000-0002-2484-9047
Projects: Not specified
Institutions: Not specifiedhttps://orcid.org/0000-0002-6586-717X
Research scientist in multi-Omics, molecular (cell)biology and bioinformatics.
Projects: HUMET Startup
Institutions: Centro de Investigación Príncipe Felipehttps://orcid.org/0000-0003-3318-120X
Tools: Computational Systems Biology, Dynamic modelling, R, Java, Bioinformatics, Data Management, Genetics, Systems Biology, Computational and theoretical biology, Databases, Genomics, Transcriptomics
My scientific interests revolve around functional genomics, systems biology and the development of algorithms and software for the analysis of high-throughput data (mainly, but not restricted to, Next Generation Sequencing) and its application to the relationship between genotype and phenotype, mainly oriented to personalized and precision medicine. I am especially interested in the study of disease mechanisms and drug action mechanisms, drug repositioning and the definition of mechanism-based
Expertise: protein secretion, stress responses, metal ion homeostasis, C- and N- metabolism, pathogens, gene regulation, virulence factors, Streptococcus), germination, bistability, Gram positive bacteria (Bacillus, competence, antimicrobial peptides, Lactococcus, sporulation, phenotypic heterogeneity
Group leader Molecular Genetics
I am final year PhD student in Prof Ian Booth's lab and a microbiologist by trade. I am interested in how enteric bacteria cope with stress and what systems they employ to increase their chances of survival, in particular upon methylglyoxal stress.
I am assistant professor at the Laboratory of Microbiology and my interest is in the area of molecular microbiology. Research focuses on the analysis of the metabolism of anaerobic fermentative bacteria and archaea, especially with respect to biofuel production (hydrogen, butanol). Within SysMo our tasks concern the effect of butanol stress, using metabolomics and transcriptomics.
Tools: molecular biological techniques (RNA/DNA techniques), protein interaction studies, DNA technology RNA technology Protein analysis Fermentation Mutagenesis, gene regulation, Proteomics (2D-PAGE), Model organisms, Proteomics, Transcriptomics, Genomics, Genetic analysis, Cell biology, Biochemistry and protein analysis, Molecular Biology, Microbiology
Optimisation of Bacillus subtilis for the secretion of heterologous proteins Therapeutic proteins (including those required for experimental purposes and clinical trials) are major products of biomanufacturing processes and considerable time and expense are expended to maximise the yield and quality of proteins produced in heterologous hosts. The production host of choice is the Gram-negative bacterium Escherichia coli for which many strains and expression systems have been developed. However,