Institutions: geneXplain GmbHhttps://orcid.org/0000-0001-6775-2467
Alexander Kel received his Ph.D. in Bioinformatics, Molecular Biology and Genetics in 1990. He studied biology and mathematics at Novosibirsk State University and obtained his M.S. in biology with special focus on mathematical biology in 1985. He worked for 15 years at the Institute of Cytology and Genetics, Russia (ICG) holding positions as a programmer, scientist, senior scientist and Vice-Head of the Laboratory of Theoretical Molecular Genetics. In 1995, he won the Academician Belaev Award.
Senior Researcher at the European Institute for Systems Biology and Medicine (EISBM), Lyon, France
The Disease Maps Project: a community effort for comprehensive representation of disease mechanisms and ‘omics data interpretation in connection to EU projects U-BIOPRED (Unbiased BIOmarkers in Prediction of REspiratory Disease outcomes) and eTRIKS (european TRanslational Information and Knowledge Management Services) funded by IMI (Innovative Medicines Initiative).
Expertise: Gram positive bacteria (Bacillus, Lactococcus, Streptococcus), competence, sporulation, germination, antimicrobial peptides, phenotypic heterogeneity, bistability, C- and N- metabolism, gene regulation, stress responses, pathogens, virulence factors, metal ion homeostasis, protein secretion
Group leader Molecular Genetics
Expertise: translational control of gene expression, gene regulation, protein-protein interactions, protein-RNA interactions, carbon catabolite regulation in Gram positive bacteria, Protein-DNA-interaction, expression systems for pro- and eukayotes, screening systems for nuclear transport and alternative splicing, inducible mammalian cell death.
Full Professor and Chairman of Microbiology
Lehrstuhl für Mikrobiologie
Institut für Biologie
91058 Erlangen, Fed. Rep. of Germany
Date of Birth: April 24, 1948
Place of Birth: Osnabrück, FRG
Children: Hauke Sven Hillen - May 17, 1987
RESEARCH AND PROFESSIONAL EXPERIENCE
Present Full Professor and Chairman of Microbiology at the Institute of Biology, Friedrich-Alexander
Expertise: Microbiology, Genetics, Molecular Biology, Bacillus subtilis, translational control of gene expression, sporulation, phenotypic heterogeneity, bistability, gene regulation, stress responses, Signal transduction in Gram-negative bacteria; Synthetic Microbiology; Single cell gene expression; Regulatory networks; biochemistry; histidine ki..., regulation of gene expression, Systems Biology
Tools: Microbiology, Genetics, Molecular Biology, Genetic analysis, Genetic modification, Model organisms, Single Cell analysis, PCR, Fluorecence based reporter gene analyses/single cell analyses, Molecular biology techniques (RNA/DNA), time lapse microscopy, Time-lapse fluorescence microscopy Flow cytometry
Expertise: Genetics, Molecular Biology, Microarray analysis, Bacillus subtilis, phenotypic heterogeneity, gene regulation, stress responses, protein secretion, functional protein expression, microscopy, fluorescence protein fusions (transcriptional and translational), localisation studies
Tools: Genetic modification, Transcriptomics, Microarray analysis, Fluorecence based reporter gene analyses/single cell analyses, Site-directed mutagenesis, Fluorescence microscopy, Flow cytometry, Immunofluorescence, transposon mutagenesis, Molecular biology techniques (RNA/DNA/Protein), DNA affinity chromatography, EMSA
PhD student. Analyzing CcpA affinity to cre boxes (catabolite responsive elements) and response of B. subtilis to membrane protein overproduction stress.
A molecular microbiologist with a passion for Clostridia! Interested in the development of more effective countermeasures (diagnosis, prevention & treatment) against pathogens, specifically Clostridium difficile and Clostridium botulinum as well as the exploitation of the medical and industrial properties of beneficial strains, specifically in cancer therapy and biofuel production