Institutions: geneXplain GmbHhttps://orcid.org/0000-0001-6775-2467
Alexander Kel received his Ph.D. in Bioinformatics, Molecular Biology and Genetics in 1990. He studied biology and mathematics at Novosibirsk State University and obtained his M.S. in biology with special focus on mathematical biology in 1985. He worked for 15 years at the Institute of Cytology and Genetics, Russia (ICG) holding positions as a programmer, scientist, senior scientist and Vice-Head of the Laboratory of Theoretical Molecular Genetics. In 1995, he won the Academician Belaev Award.
Projects: HUMET Startup
Institutions: European Institute for Systems Biology and Medicinehttps://orcid.org/0000-0001-7137-4171
Senior Researcher at the European Institute for Systems Biology and Medicine (EISBM), Lyon, France
The Disease Maps Project: a community effort for comprehensive representation of disease mechanisms and ‘omics data interpretation in connection to EU projects U-BIOPRED (Unbiased BIOmarkers in Prediction of REspiratory Disease outcomes) and eTRIKS (european TRanslational Information and Knowledge Management Services) funded by IMI (Innovative Medicines Initiative).
Expertise: protein secretion, gene regulation, virulence factors, stress responses, metal ion homeostasis, C- and N- metabolism, pathogens, Lactococcus, sporulation, phenotypic heterogeneity, Streptococcus), germination, bistability, Gram positive bacteria (Bacillus, competence, antimicrobial peptides
Group leader Molecular Genetics
Expertise: carbon catabolite regulation in Gram positive bacteria, screening systems for nuclear transport and alternative splicing, Protein-DNA-interaction, inducible mammalian cell death., expression systems for pro- and eukayotes, protein-RNA interactions, protein-protein interactions, gene regulation, translational control of gene expression
Full Professor and Chairman of Microbiology
Lehrstuhl für Mikrobiologie
Institut für Biologie
91058 Erlangen, Fed. Rep. of Germany
Date of Birth: April 24, 1948
Place of Birth: Osnabrück, FRG
Children: Hauke Sven Hillen - May 17, 1987
RESEARCH AND PROFESSIONAL EXPERIENCE
Present Full Professor and Chairman of Microbiology at the Institute of Biology, Friedrich-Alexander
Expertise: Systems Biology, regulation of gene expression, Signal transduction in Gram-negative bacteria; Synthetic Microbiology; Single cell gene expression; Regulatory networks; biochemistry; histidine ki..., gene regulation, stress responses, bistability, sporulation, phenotypic heterogeneity, translational control of gene expression, Bacillus subtilis, Molecular Biology, Genetics, Microbiology
Tools: Time-lapse fluorescence microscopy Flow cytometry, time lapse microscopy, Molecular biology techniques (RNA/DNA), Fluorecence based reporter gene analyses/single cell analyses, PCR, Model organisms, Single Cell analysis, Genetic modification, Genetic analysis, Molecular Biology, Genetics, Microbiology
Expertise: fluorescence protein fusions (transcriptional and translational), localisation studies, microscopy, protein secretion, functional protein expression, gene regulation, stress responses, phenotypic heterogeneity, Bacillus subtilis, Microarray analysis, Molecular Biology, Genetics
Tools: DNA affinity chromatography, EMSA, Molecular biology techniques (RNA/DNA/Protein), transposon mutagenesis, Immunofluorescence, Fluorescence microscopy, Flow cytometry, Site-directed mutagenesis, Fluorecence based reporter gene analyses/single cell analyses, Microarray analysis, Transcriptomics, Genetic modification
PhD student. Analyzing CcpA affinity to cre boxes (catabolite responsive elements) and response of B. subtilis to membrane protein overproduction stress.
A molecular microbiologist with a passion for Clostridia! Interested in the development of more effective countermeasures (diagnosis, prevention & treatment) against pathogens, specifically Clostridium difficile and Clostridium botulinum as well as the exploitation of the medical and industrial properties of beneficial strains, specifically in cancer therapy and biofuel production