Eriko Takano

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About Eriko Takano:

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SEEK ID: https://fairdomhub.org/people/107

Location: Netherlands

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SysMO

SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".

The goal pursued by SysMO was to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.

Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...

Projects: BaCell-SysMO, COSMIC, SUMO, KOSMOBAC, SysMO-LAB, PSYSMO, SCaRAB, MOSES, TRANSLUCENT, STREAM, SulfoSys, SysMO DB, SysMO Funders, SilicoTryp, Noisy-Strep

Web page: http://sysmo.net/

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STREAM

Global metabolic switching in Streptomyces coelicolor

Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.

Programme: SysMO

Public web page: Not specified

Organisms: Streptomyces coelicolor

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University of Groningen

Country: Netherlands

City: Groningen

Web page: http://www.rug.nl/corporate/index

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Metabolism of Streptomyces coelicolor (SysMO STREAM)

STREAM, SYSTERACT

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One of these activities is antibiotic production and is widespread in streptomycetes ...

Submitter: Jay Moore

Studies: ScoCyc metabolic pathway curation, Timeseries 1

Assays: Metabolic pathway curation, Online/offline measurements, metabolomics, proteomics, transcriptomics

Snapshots: No snapshots

Created: 26th May 2010 at 13:44, Last updated: 3rd Dec 2016 at 21:28

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Timeseries 1

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Genotype: Wildtype (M145E) Medium: Phosphate-limited (F134)

Submitter: Jay Moore

Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...

Assays: Online/offline measurements, metabolomics, proteomics, transcriptomics

Snapshots: No snapshots

Created: 26th May 2010 at 13:47, Last updated: 2nd Nov 2016 at 08:38

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Fermentor 199 transcriptomics

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Investigations: Metabolism of Streptomyces coelicolor (SysMO ST...

Studies: Timeseries 1

Assays: transcriptomics

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Created: 4th Nov 2010 at 13:35, Last updated: 3rd Dec 2016 at 19:37

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Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor

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Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism. Here we …

Authors: , , The STREAM Consortium (stream), , , ,

Date Published: 2010

Publication Type: Not specified

DOI: 10.1186/1471-2164-11-202

Citation:

Created: 26th May 2010 at 13:17, Last updated: 8th Dec 2022 at 17:25

The dynamic architecture of the metabolic switch in Streptomyces coelicolor

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BACKGROUND: During the lifetime of a fermenter culture, the soil bacterium S. coelicolor undergoes a major metabolic switch from exponential growth to antibiotic production. We have studied gene …

Authors: , Florian Battke, Alexander Herbig, , , , , , , , , Edward R Morrissey, Miguel A Juarez-Hermosillo, , Merle Nentwich, , Mudassar Iqbal, , , , , , , , Michael Bonin, , , , , , , , , ,

Date Published: 28th May 2009

Publication Type: Not specified

PubMed ID: 20053288

Citation:

Created: 26th May 2010 at 13:21, Last updated: 8th Dec 2022 at 17:25

Chapter 6. Regulation of antibiotic production by bacterial hormones

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Abstract (Expand)

Antibiotic production is regulated by numerous signals, including the so-called bacterial hormones found in antibiotic producing organisms such as Streptomyces. These signals, the gamma-butyrolactones, …

Authors: Nai-Hua Hsiao, Marco Gottelt,

Date Published: 21st Apr 2009

Publication Type: Not specified

PubMed ID: 19374982

Citation:

Created: 26th May 2010 at 14:42, Last updated: 8th Dec 2022 at 17:25

A bistable gene switch for antibiotic biosynthesis: the butyrolactone regulon in Streptomyces coelicolor

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Many microorganisms, including bacteria of the class Streptomycetes, produce various secondary metabolites including antibiotics to gain a competitive advantage in their natural habitat. The production … of these compounds is highly coordinated in a population to expedite accumulation to an effective concentration. Furthermore, as antibiotics are often toxic even to their producers, a coordinated production allows microbes to first arm themselves with a defense mechanism to resist their own antibiotics before production commences. One possible mechanism of coordination among individuals is through the production of signaling molecules. The gamma-butyrolactone system in Streptomyces coelicolor is a model of such a signaling system for secondary metabolite production. The accumulation of these signaling molecules triggers antibiotic production in the population. A pair of repressor-amplifier proteins encoded by scbA and scbR mediates the production and action of one particular gamma-butyrolactone, SCB1. Based on the proposed interactions of scbA and scbR, a mathematical model was constructed and used to explore the ability of this system to act as a robust genetic switch. Stability analysis shows that the butyrolactone system exhibits bistability and, in response to a threshold SCB1 concentration, can switch from an OFF state to an ON state corresponding to the activation of genes in the cryptic type I polyketide synthase gene cluster, which are responsible for production of the hypothetical polyketide. The switching time is inversely related to the inducer concentration above the threshold, such that short pulses of low inducer concentration cannot switch on the system, suggesting its possible role in noise filtering. In contrast, secondary metabolite production can be triggered rapidly in a population of cells producing the butyrolactone signal due to the presence of an amplification loop in the system. S. coelicolor was perturbed experimentally by varying concentrations of SCB1, and the model simulations match the experimental data well. Deciphering the complexity of this butyrolactone switch will provide valuable insights into how robust and efficient systems can be designed using "simple" two-protein networks.

Authors: Sarika Mehra, Salim Charaniya, , Wei-Shou Hu

Date Published: 2nd May 2008

Publication Type: Not specified

PubMed ID: 18628968

Citation:

Created: 26th May 2010 at 13:26, Last updated: 8th Dec 2022 at 17:25