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SEEK ID: https://fairdomhub.org/assays/55
Experimental Assay
Investigation: Metabolism of Streptomyces coelicolor (SysMO STREAM)
Study: Timeseries 1
Assay type: Transcriptomics
Technology type: Custom Array
Organisms: Streptomyces coelicolor : M145 (wild-type / wild-type) (batch)
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Created: 26th May 2010 at 16:23
Last updated: 8th Nov 2017 at 15:21
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Projects: STREAM
Institutions: University of Warwick
Systems Biologist specialising in data integration, high-throughput sequence analysis, and evolutionary and comparative analyses.
There is an urgent need for novel antibiotics to fight life-threatening infections and to counteract the increasing problem of propagating antibiotic resistance. Recently, new molecular genetic and biochemical tools have provided insight into the enormous unexploited genetic pool of environmental microbial biodiversity for new antibiotic compounds. New tools for more efficiently lifting this hidden treasure are needed to strengthen competitiveness of European industry, as well as for a cost-saving
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Programme: ERASysAPP
Public web page: https://www.erasysapp.eu/calls/2nd-call/systeract
Organisms: Streptomyces coelicolor
Global metabolic switching in Streptomyces coelicolor
Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.
Programme: SysMO
Public web page: Not specified
Organisms: Streptomyces coelicolor
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Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.
One of these activities is antibiotic production and is widespread in streptomycetes
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Snapshots: No snapshots
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Genotype: Wildtype (M145E)
Medium: Phosphate-limited (F134)
Person responsible: Jay Moore
Snapshots: No snapshots
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Assays: Online/offline measurements, metabolomics, proteomics, transcriptomics
Submitter: Jay Moore
Provider Name: Not specified
Provider's strain ID: Not specified
Organism: Streptomyces coelicolor
Genotypes: wild-type
Phenotypes: wild-type
Comment: Not specified
All contributors
Creators: Jay Moore, Juan-Francisco Martin, Antonio Rodríguez-García, Trond Ellingsen, Øyvind Jakobsen, Per Bruheim, Håvard Sletta, Anders Øverby, Sven Even Borgos, Sunniva Hoel, Alexander Wentzel, Maggie Smith, Louise Thomas, Eriko Takano, Lubbert Dijkhuizen, Rainer Breitling, M. Tauqeer Alam, Anthony Palathingal, R Jansen, Maria Elena Merlo, Morris Swertz, Preben Krabben, Kay Nieselt, Wolfgang Wohlleben, Jens Reuther, David Hodgson, David Rand, David Wild, Elizabeth Wellington, Gregory Challis, Nigel Burroughs, Walid Omara, William Gaze, Brent Kiernan, Roxane Legaie
Submitter: Jay Moore
Relationship type: Not specified
Investigations: Metabolism of Streptomyces coelicolor (SysMO ST...
Studies: Timeseries 1
Assays: transcriptomics