Rainer Breitling
I am currently Professor of Systems Biology at the University of Manchester. My research interests focus on the development of innovative computational approaches for post-genomic systems biology, statistical methods for high-throughput biological experimentation and the dynamic modelling of cellular systems. This work is highly interdisciplinary and usually involves close collaboration with experimental biologists and clinicians. A recurrently theme is the study of complex cellular networks at various molecular levels. Recently, a large part of my work has focused on exploiting high-accuracy mass spectrometry for metabolomics systems biology, for example in studies of the metabolic networks of protozoan parasites and the synthetic biology of antibiotic production in actinomycetes.
SEEK ID: https://fairdomhub.org/people/115
Location:
Netherlands
Expertise: Systems Biology, Metabolomics, Transcriptomics
Tools: constraint-based modeling, Computational Systems Biology, Bioinformatics
ORCID: Not specified
Project roles
Asset housekeeper
Rainer's tagsRelated items
Global metabolic switching in Streptomyces coelicolor
Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.
Programme: SysMO
Public web page: Not specified
The SilicoTryp project aims at the creation of a “Silicon Trypanosome”, a comprehensive, experiment-based, multi-scale mathematical model of trypanosome physiology.
Trypanosomes are blood-stream parasites transmitted by tsetse flies; they cause African sleeping sickness in humans and livestock. Currently available drugs have severe side effects, and the parasites are rapidly developing resistance.
In this project, we collect a wide range of new experimental data on the parasite in its various
...
Programme: SysMO
Public web page: http://silicotryp.ibls.gla.ac.uk/wiki/Main_Page
Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.
One of these activities is antibiotic production and is widespread in streptomycetes
...
Snapshots: No snapshots
Genotype: Wildtype (M145E)
Medium: Phosphate-limited (F134)
Person responsible: Jay Moore
Snapshots: No snapshots
Creators: Jay Moore, Juan-Francisco Martin, Antonio Rodríguez-García, Trond Ellingsen, Øyvind Jakobsen, Per Bruheim, Håvard Sletta, Anders Øverby, Sven Even Borgos, Sunniva Hoel, Alexander Wentzel, Maggie Smith, Louise Thomas, Eriko Takano, Lubbert Dijkhuizen, Rainer Breitling, M. Tauqeer Alam, Anthony Palathingal, R Jansen, Maria Elena Merlo, Morris Swertz, Preben Krabben, Kay Nieselt, Wolfgang Wohlleben, Jens Reuther, David Hodgson, David Rand, David Wild, Elizabeth Wellington, Gregory Challis, Nigel Burroughs, Walid Omara, William Gaze, Brent Kiernan, Roxane Legaie
Contributor: Jay Moore
Download
SBML file supplementary material of the publication.
Creators: Fiona Achcar, Barbara Bakker, Mike Barrett, Rainer Breitling, Eduard Kerkhoven
Contributor: Fiona Achcar
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: Not specified
Abstract (Expand)
Authors: Eduard Kerkhoven, Fiona Achcar, V. P. Alibu, R. J. Burchmore, I. H. Gilbert, M. Trybilo, N. N. Driessen, D. Gilbert, Rainer Breitling, Barbara Bakker, Mike Barrett
Date Published: 5th Dec 2013
Journal: PLoS Comput Biol
Abstract (Expand)
Authors: Fiona Achcar, Abeer Fadda, Jurgen Haanstra, Eduard Kerkhoven, Dong-Hyun Kim, Alejandro Leroux, T. Papamarkou, Federico Rojas, Barbara Bakker, Mike Barrett, Christine Clayton, Mark Girolami, Luise Krauth-Siegel, Keith Matthews, Rainer Breitling
Date Published: 7th May 2014
Journal: Adv Microb Physiol
Abstract (Expand)
Authors: None
Date Published: 19th Jan 2012
Journal: PLoS Comput Biol
Abstract (Expand)
Authors: None
Date Published: 17th Feb 2010
Journal: Parasitology
Abstract (Expand)
Authors: Barbara Bakker, Luise Krauth-Siegel, Christine Clayton, Keith Matthews, Mark Girolami, Hans Westerhoff, Paul A M Michels, Rainer Breitling, Mike Barrett
Date Published: 6th May 2010
Journal: Parasitology
Abstract (Expand)
Authors: Richard A Scheltema, Anas Kamleh, David Wildridge, Charles Ebikeme, David G Watson, Michael P Barrett, R Jansen, Rainer Breitling
Date Published: 22nd Oct 2008
Journal: Proteomics
Abstract (Expand)
Authors: Simon Rogers, Richard A Scheltema, Mark Girolami, Rainer Breitling
Date Published: 18th Dec 2008
Journal: Bioinformatics
Abstract (Expand)
Authors: Fabien Jourdan, Rainer Breitling, Michael P Barrett, David Gilbert
Date Published: 14th Nov 2007
Journal: Bioinformatics
Abstract (Expand)
Authors: Rainer Breitling, Dennis Vitkup, Michael P Barrett
Date Published: 21st Nov 2007
Journal: Nat. Rev. Microbiol.
Abstract (Expand)
Authors: Kay Nieselt, Florian Battke, Alexander Herbig, Per Bruheim, Alexander Wentzel, Øyvind Jakobsen, Håvard Sletta, M. Tauqeer Alam, Maria Elena Merlo, Jay Moore, Walid Omara, Edward R Morrissey, Miguel A Juarez-Hermosillo, Antonio Rodríguez-García, Merle Nentwich, Louise Thomas, Mudassar Iqbal, Roxane Legaie, William Gaze, Gregory Challis, R Jansen, Lubbert Dijkhuizen, David Rand, David Wild, Michael Bonin, Jens Reuther, Wolfgang Wohlleben, Maggie Smith, Nigel Burroughs, Juan-Francisco Martin, David Hodgson, Eriko Takano, Rainer Breitling, Trond Ellingsen, Elizabeth Wellington
Date Published: 28th May 2009
Journal: BMC Genomics
Abstract (Expand)
Authors: M. Tauqeer Alam, Maria Elena Merlo, The STREAM Consortium (stream), David Hodgson, Elizabeth Wellington, Eriko Takano, Rainer Breitling
Date Published: 2010
Journal: BMC Genomics
