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- Rainer Breitling
I am currently Professor of Systems Biology at the University of Manchester. My research interests focus on the development of innovative computational approaches for post-genomic systems biology, statistical methods for high-throughput biological experimentation and the dynamic modelling of cellular systems. This work is highly interdisciplinary and usually involves close collaboration with experimental biologists and clinicians. A recurrently theme is the study of complex cellular networks at various molecular levels. Recently, a large part of my work has focused on exploiting high-accuracy mass spectrometry for metabolomics systems biology, for example in studies of the metabolic networks of protozoan parasites and the synthetic biology of antibiotic production in actinomycetes.
SEEK ID: https://fairdomhub.org/people/115
Location:
Netherlands
Expertise: Systems Biology, Metabolomics, Transcriptomics
Tools: constraint-based modeling, Computational Systems Biology, Bioinformatics
ORCID: Not specified
Related items
- Projects (2)
- Institutions (1)
- Investigations (1)
- Studies (1)
- Data files (1)
- Models (1)
- Publications (11)
Global metabolic switching in Streptomyces coelicolor
Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.
Programme: SysMO
Public web page: Not specified
Organisms: Streptomyces coelicolor
The SilicoTryp project aims at the creation of a “Silicon Trypanosome”, a comprehensive, experiment-based, multi-scale mathematical model of trypanosome physiology.
Trypanosomes are blood-stream parasites transmitted by tsetse flies; they cause African sleeping sickness in humans and livestock. Currently available drugs have severe side effects, and the parasites are rapidly developing resistance.
In this project, we collect a wide range of new experimental data on the parasite in its various
...
Programme: SysMO
Public web page: http://silicotryp.ibls.gla.ac.uk/wiki/Main_Page
Organisms: Trypanosoma brucei
All contributors
Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.
One of these activities is antibiotic production and is widespread in streptomycetes
...
Snapshots: No snapshots
All contributors
Genotype: Wildtype (M145E)
Medium: Phosphate-limited (F134)
Person responsible: Jay Moore
Snapshots: No snapshots
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Assays: Online/offline measurements, metabolomics, proteomics, transcriptomics
All contributors
Creators: Jay Moore, Juan-Francisco Martin, Antonio Rodríguez-García, Trond Ellingsen, Øyvind Jakobsen, Per Bruheim, Håvard Sletta, Anders Øverby, Sven Even Borgos, Sunniva Hoel, Alexander Wentzel, Maggie Smith, Louise Thomas, Eriko Takano, Lubbert Dijkhuizen, Rainer Breitling, M. Tauqeer Alam, Anthony Palathingal, R Jansen, Maria Elena Merlo, Morris Swertz, Preben Krabben, Kay Nieselt, Wolfgang Wohlleben, Jens Reuther, David Hodgson, David Rand, David Wild, Elizabeth Wellington, Gregory Challis, Nigel Burroughs, Walid Omara, William Gaze, Brent Kiernan, Roxane Legaie
Contributor: Jay Moore
Investigations: Metabolism of Streptomyces coelicolor (SysMO ST...
Studies: Timeseries 1
Assays: transcriptomics
SBML file supplementary material of the publication.
Creators: Fiona Achcar, Barbara Bakker, Mike Barrett, Rainer Breitling, Eduard Kerkhoven
Contributor: Fiona Achcar
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: Not specified
Organism: Trypanosoma brucei
Investigations: No Investigations
Studies: No Studies
Modelling analyses: No Modelling analyses
Abstract (Expand)
Authors: Eduard Kerkhoven, Fiona Achcar, Rainer Breitling, Barbara Bakker, Mike Barrett, Alibu V. P.,Burchmore R. J.,Gilbert I. H.,Trybilo M.,Driessen N. N.,Gilbert D.
Date Published: 5th Dec 2013
Journal: PLoS Comput Biol
PubMed ID: 24339766
Citation:
Abstract (Expand)
Authors: Fiona Achcar, Abeer Fadda, Jurgen Haanstra, Eduard Kerkhoven, Dong-Hyun Kim, Alejandro Leroux, Federico Rojas, Barbara Bakker, Mike Barrett, Christine Clayton, Mark Girolami, Luise Krauth-Siegel, Keith Matthews, Rainer Breitling, Papamarkou T.
Date Published: 7th May 2014
Journal: Adv Microb Physiol
PubMed ID: 24797926
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Abstract (Expand)
Authors: None
Date Published: 19th Jan 2012
Journal: PLoS Comput Biol
DOI: 10.1371/journal.pcbi.1002352
Citation:
Abstract (Expand)
Authors: None
Date Published: 17th Feb 2010
Journal: Parasitology
PubMed ID: 20158937
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Abstract (Expand)
Authors: Barbara Bakker, Luise Krauth-Siegel, Christine Clayton, Keith Matthews, Mark Girolami, Hans Westerhoff, Rainer Breitling, Mike Barrett, Michels Paul A M
Date Published: 6th May 2010
Journal: Parasitology
PubMed ID: 20444304
Citation:
Abstract (Expand)
Authors: R Jansen, Rainer Breitling, Scheltema Richard A,Kamleh Anas,Wildridge David,Ebikeme Charles,Watson David G,Barrett Michael P
Date Published: 22nd Oct 2008
Journal: Proteomics
PubMed ID: 18937253
Citation:
Abstract (Expand)
Authors: Rainer Breitling, Rogers Simon,Scheltema Richard A,Girolami Mark
Date Published: 18th Dec 2008
Journal: Bioinformatics
PubMed ID: 19095699
Citation:
Abstract (Expand)
Authors: Rainer Breitling, Jourdan Fabien,Barrett Michael P,Gilbert David
Date Published: 14th Nov 2007
Journal: Bioinformatics
PubMed ID: 18003642
Citation:
Abstract (Expand)
Authors: Rainer Breitling, Vitkup Dennis,Barrett Michael P
Date Published: 21st Nov 2007
Journal: Nat. Rev. Microbiol.
PubMed ID: 18026122
Citation:
All contributors
Abstract (Expand)
Authors: Kay Nieselt, Per Bruheim, Alexander Wentzel, Øyvind Jakobsen, Håvard Sletta, M. Tauqeer Alam, Maria Elena Merlo, Jay Moore, Walid Omara, Antonio Rodríguez-García, Louise Thomas, Roxane Legaie, William Gaze, Gregory Challis, R Jansen, Lubbert Dijkhuizen, David Rand, David Wild, Jens Reuther, Wolfgang Wohlleben, Maggie Smith, Nigel Burroughs, Juan-Francisco Martin, David Hodgson, Eriko Takano, Rainer Breitling, Trond Ellingsen, Elizabeth Wellington, Battke Florian,Herbig Alexander,Morrissey Edward R,Juarez-Hermosillo Miguel A,Nentwich Merle,Iqbal Mudassar,Bonin Michael
Date Published: 28th May 2009
Journal: BMC Genomics
PubMed ID: 20053288
Citation: