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Created: 4th Nov 2010 at 14:35
Last updated: 3rd Dec 2016 at 20:37
Last used: 8th Dec 2019 at 14:52

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Institutions: University of Groningen
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Institutions: SINTEF, Norwegian University of Science and Technology
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Expertise: Analytical chemistry, Stoichiometric modelling, Pseudomonas, Prokaryotic genetics, Streptomyces, Data analysis, Microarray analysis, Bioinformatics
Tools: FT-ICR-MS, Mass spectrometry (LC-MS/MS), Field Flow Fractionation, Mass spectrometry, MS imaging, Pathway Tools, GC and LC analysis of metabolites, Fermentation, Perl, Transcriptomics
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Institutions: University of Tuebingen, University of Tübingen
Global metabolic switching in Streptomyces coelicolor
Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.
Programme: SysMO
Public web page: Not specified
Organisms: Streptomyces coelicolor
All contributors
Antibiotics are made during the second phase of growth when there is a transition in metabolism from primary to secondary metabolism. Primary metabolism is growth related and involves all the normal cellular activities associated with cell growth and division. Whereas secondary metabolism is non-growth linked and is non-essential but many important activities occur during this phase which help the bacterium survive.
One of these activities is antibiotic production and is widespread in streptomycetes
...
Snapshots: No snapshots
All contributors
Genotype: Wildtype (M145E)
Medium: Phosphate-limited (F134)
Person responsible: Jay Moore
Snapshots: No snapshots
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Assays: Online/offline measurements, metabolomics, proteomics, transcriptomics
Contributor: Jay Moore
Assay type: Transcriptomics
Technology type: Custom Array
Snapshots: No snapshots
Investigation: Metabolism of Streptomyces coelicolor (SysMO ST...
Study: Timeseries 1
Organisms: Streptomyces coelicolor : M145 (wild-type / wild-type) (batch)
SOPs: No SOPs
Data files: Fermentor 199 transcriptomics
Abstract (Expand)
Authors: F. Battke, A. Herbig, A. Wentzel, O. M. Jakobsen, M. Bonin, D. A. Hodgson, W. Wohlleben, T. E. Ellingsen, K. Nieselt
Date Published: 25th Mar 2011
Journal: Adv Exp Med Biol
PubMed ID: 21431541
Citation: Adv Exp Med Biol. 2011;696:3-15. doi: 10.1007/978-1-4419-7046-6_1.
All contributors
Abstract (Expand)
Authors: Kay Nieselt, Florian Battke, Alexander Herbig, Per Bruheim, Alexander Wentzel, Øyvind Jakobsen, Håvard Sletta, M. Tauqeer Alam, Maria Elena Merlo, Jay Moore, Walid Omara, Edward R Morrissey, Miguel A Juarez-Hermosillo, Antonio Rodríguez-García, Merle Nentwich, Louise Thomas, Mudassar Iqbal, Roxane Legaie, William Gaze, Gregory Challis, R Jansen, Lubbert Dijkhuizen, David Rand, David Wild, Michael Bonin, Jens Reuther, Wolfgang Wohlleben, Maggie Smith, Nigel Burroughs, Juan-Francisco Martin, David Hodgson, Eriko Takano, Rainer Breitling, Trond Ellingsen, Elizabeth Wellington
Date Published: 28th May 2009
Journal: BMC Genomics
PubMed ID: 20053288
Citation: