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Projects: OXYMOD
Institutions: Norwegian University of Science and Technology

Projects: WineSys, INBioPharm, BioZEment 2.0, CoolWine, Auromega
Institutions: Norwegian University of Science and Technology

Projects: The Beer Project
Institutions: Norwegian University of Science and Technology
Projects: C19DM - Macrophage logical model
Institutions: Norwegian University of Science and Technology

Expertise: Systems Biology, Bioinformatics, Immunology, Molecular Biology
Tools: GINsim, Cytoscape, Computational and theoretical biology, Databases, data modeling
Projects: SCaRAB, STREAM, SYSTERACT, INBioPharm
Institutions: SINTEF, Norwegian University of Science and Technology
Roles: Postdoc
Expertise: Bioinformatics, Microarray analysis, Data analysis, Pseudomonas, Streptomyces, Stoichiometric modelling, Prokaryotic genetics, Analytical chemistry
Tools: Transcriptomics, Perl, Fermentation, GC and LC analysis of metabolites, Pathway Tools, MS imaging, Mass spectrometry (LC-MS/MS), Mass spectrometry, FT-ICR-MS, Field Flow Fractionation
Senior Research Scientist at SINTEF, Dept. of Biotechnology and Nanomedicine, Research Group Mass Spectrometry
Projects: MetApp, LEANPROT, C1Pro
Institutions: SINTEF, Norwegian University of Science and Technology
Since 1st of January 2015 I am Professor in synthetic biology at the Norwegian University of Science and Technology (NTNU) institute of biotechnology. Before that I was research director in the non-profit research institution SINTEF. My major research activities are within microbial molecular biology, mainly combining metabolic engineering, synthetic biology and systems biology to develop microbial cell factories, and focusing both on the products and on the raw materials. The research includes
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Projects: STREAM, SCaRAB, WineSys, INBioPharm
Institutions: SINTEF, Norwegian University of Science and Technology
Expertise: Metabolomics
Projects: OXYMOD
Institutions: Norwegian University of Science and Technology

Roles: Postdoc
Expertise: protein NMR, lytic polysaccharide monooxygenases
Tools: NMR, Molecular Biology, Biochemistry and protein analysis, Python
Projects: C19DM - Macrophage logical model
Institutions: Norwegian University of Science and Technology
Projects: C1Pro
Institutions: Norwegian University of Science and Technology
Projects: CausalDB, Colosys, NTNU Health Druglogics
Institutions: Norwegian University of Science and Technology

Projects: LEANPROT
Institutions: Norwegian University of Science and Technology
Projects: NTNU Health Druglogics
Institutions: Norwegian University of Science and Technology
Expertise: Software Engineering
Roles: PhD Student, Postdoc
Expertise: Microbiology, Molecular Biology, Transcriptomics
Tools: Microbiology, Molecular Biology, Transcriptomics, Molecular biology techniques (RNA/DNA/Protein)
I am a PostDoc in prof. Brautaset's lab at NTNU in Trondheim, Norway. During my Ph studies D, Irla was involved in two ERA projects; SynMet and MetAPP (PAL) and currently in I am active in C1Pro project (Asset housekeeper). I have been working with methylotrophic Bacillus methanolicus since 2012, in that time I have been involved in engineering of that bacterium for production of different value-added products (amino acids and their derivatives, vitamins, and others). Furthermore, I have improved
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Projects: BioZEment 2.0
Institutions: Norwegian University of Science and Technology

Projects: Systems toxicology of Atlantic cod
Institutions: Norwegian University of Science and Technology
Projects: CoolWine
Institutions: Norwegian University of Science and Technology
In this project, we integrate COVID19 Disease Maps curated regulatory information in a macrophage logical model.
This allows logical simulations of the effects of acute inflammation caused by the SARS-CoV-2 virus, both in general and in a cell-specific perspective. Moreover, understanding the regulatory network behavior of macrophages following infection opens new ways to test and predict drug and drug combination effects, as a first step towards the development of new treatments.
Organisms: Homo sapiens
Centre for Digital Life Norway (DLN) project 'OXYMOD - Optimized oxidative enzyme systems for efficient conversion of lignocellulose to valuable products'
Programme: DLN - OXYMOD
Public web page: https://digitallifenorway.org/gb/projects/oxymod
Organisms: Not specified
Programme: Systems Brewology
Public web page: Not specified
Organisms: Not specified
This is a sandbox where DigiSal members can learn to use the SEEK.
Tutorial document: http://tinyurl.com/seek-ds17
The SEEK is a web interface to a database of research "assets" organised in a hierarchical "ISA structure" (investigation-study-assay) [1].
These are further organised into projects and programmes.
* Programme = Overarching research theme (The Digital Salmon)
* Project = Research grant (DigiSal, GenoSysFat)
* Investigation = a particular biological process, phenomenon or thing
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Programme: The Digital Salmon
Public web page: http://www.nmbu.no/prosjekter/digisal
Organisms: Salmo salar
Salmon farmed on modern feeds contains less of the healthy, long-chain fatty acids (EPA and DHA) than before. Up until the turn of the millennium, farmed salmon were fed fish oil as a replacement for their omega-3 rich natural prey. However, fish oil is now a scarce resource, and more than half of the fat in modern feeds comes from plant oils that are inexpensive, but devoid of long-chain omega-3 fatty acids. How can we increase the omega-3 content of salmon on sustainable feeds?
One option is
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Programme: The Digital Salmon
Public web page: http://tinyurl.com/genosysfat
Organisms: Danio rerio, Salmo salar, Oncorhynchus mykiss
Towards the Digital Salmon: From a reactive to a pre-emptive research strategy in aquaculture (DigiSal)
Salmon farming in the future must navigate conflicting and shifting demands of sustainability, shifting feed prices, disease, and product quality. The industry needs to develop a flexible, integrated basis of knowledge for rapid response to new challenges. Project DigiSal will lay the foundations for a Digital Salmon: an ensemble of mathematical descriptions of salmon physiology, combining
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Programme: The Digital Salmon
Public web page: http://tinyurl.com/digisal
Organisms: Danio rerio, Salmo salar, Oncorhynchus mykiss
Increasing temperature in the European wine producing regions is having a negative impact on this key sector. Climate change results in a lack of balance between technological and phenolic ripening of wine grapes and, as a consequence, alcohol increase in wines. This trend is of great concern for the European wine industry because it has a negative impact on wine quality, becomes a hurdle for international trade, and jeopardizes compatibility of moderate wine consumption with a healthy lifestyle.
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Programme: CoolWine
Public web page: Not specified
Organisms: Saccharomyces cerevisiae
Programme: COMBINE (Computational Modeling in Biology Network)
Public web page: https://multicellml.org/
Organisms: Not specified
Coastal zones and oceans constitute an essential fundament for Norway’s history as well as current economy, providing ecosystem services for fisheries, aquaculture, transport, tourism, and recreation. The petroleum activities in Norwegian waters have been crucial for Norway’s financial growth and in financing the Norwegian welfare state. As the pressure on the oceans continuously increases, both the petroleum industry and the seafood industries have acknowledged that awareness and actions are
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Programme: dCod 1.0: decoding systems toxicology of cod
Public web page: http://www.uib.no/en/dcod
Organisms: Gadus morhua
Programme: DiaPhotosynth
Public web page: Not specified
Start date: 3rd Feb 2020
End date: 31st Aug 2023
Organisms: Phaeodactylum tricornutum
Programme: DiaPhotosynth
Public web page: Not specified
Start date: 1st Sep 2020
End date: 31st Aug 2023
Organisms: Phaeodactylum tricornutum
Programme: BioZEment
Public web page: https://digitallifenorway.org/gb/projects/biozement-2-0
Organisms: Not specified
ERACoBioTech project
Programme: Era CoBioTech
Public web page: https://www.ntnu.edu/c1pro
Organisms: Bacillus methanolicus
A joint NTNU and SINTEF project to establish a knowledge platform on DHA synthesis and lipid accumulation in the native DHA-producing thraustochytrids, and to develop these into high productivity omega-3 fatty acid producing cell factories.
Programme: Auromega
Public web page: https://digitallifenorway.org/prosjekter/auromega
Organisms: Aurantiochytrium sp. T66
The COLOSYS project aims to develop a deeper understanding of colon cancer networks and convert them into computer models with which it will be better to predict response to treatment. The combination of computational, experimental and clinical testing will provide understanding of drug resistance mechanisms, and allow personalised treatment of colon cancer.
Programme: Druglogics
Public web page: http://www.colosys.org/
Organisms: Homo sapiens
INBioPharm - Integrated Novel Natural Product Discovery and Production Platform for Accelerated Biopharmaceutical Innovation from Microbial Biodiversity project will develop a new, generic technology platform for the more efficient discovery of novel bioactive compounds with improved prospects to become medical products. A unique national collection of marine microorganisms at SINTEF/NTNU will be used as the basis for the development of different new, complementary molecular biology, analytical
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Programme: Independent Projects
Public web page: https://digitallifenorway.org/gb/projects/inbiopharm
Organisms: Streptomyces coelicolor
Glycon proposal preparation
Programme: Model repository for M4 (Make Me My Model) clients of ISBE
Public web page: Not specified
Organisms: Sulfobacillus thermosulfidooxidans
The project “Rational development of anti-cancer combinations” focuses on precision medicine for cancer by pursuing novel insight into cancer disease mechanisms, combinatorial drug treatment in order to enable selection of the best treatment for the individual patient. The aim is to develop and integrate computational, experimental and analytical approaches to predict and validate anti-cancer drug combinations and produce an integrated pipeline for rational screening of synergistic drugs and for
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Programme: Druglogics
Public web page: https://www.ntnu.edu/health/druglogics
Organisms: Not specified
In the project “Crossover Research 2.0 – Well constructed Knowledge Commons” the domain of precision medicine is explored as a key visionary driver for developing the Knowledge Commons and the enabling of Systems Biology approaches to innovate healthcare. In particular, we seek to engage stakeholder concerns in investigating and establishing strategies for DrugLogics to contribute to the Knowledge Commons in an RRI mode.
Programme: Druglogics
Public web page: http://www.ntnu.edu/crossover-research
Organisms: Not specified
Escherichia coli is a well-established and the most widely used organism for the production of recombinant proteins (used in medical and industrial applications, as molecular biology reagents, etc.). Production of proteins is the most resource exhaustive process for the cells and therefore needs to be optimized to achieve maximal productivities. Natural environment of E. coli is much harsher compared to the near optimal growth conditions used in production processes. In order to survive cells
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Programme: ERASysAPP
Public web page: https://www.bioprocess.tu-berlin.de/menue/research/projects/leanprot/
Organisms: Escherichia coli