Amino alcohol moieties are found in highly diverse classes of natural products that are of great importance due to their bioactivity, and they function as chiral building blocks for the synthesis of pharmaceuticals and agrochemicals. The chemical synthesis of stereoisomerically pure amino alcohols is difficult and typically requires uneconomical steps for protective group manipulations. Conventional syntheses in the chemical industry often use hazardous substances, consume large amounts of energy and generate toxic waste.
The TRALAMINOL project will address the challenges with the innovative development of sustainable biotechnological processes for the synthesis of amino alcohols through a multi-disciplinary approach.The consortium assembles leading European research groups (Germany, UK, Spain, France) with different but complementary scientific and technological expertise (4 non-profit organizations, 1 SME, 1 large company). TRALAMINOL will focus on the development of a powerful one-pot two-step biocatalytic strategy based on only two classes of reaction types: The approach makes use of key enzymes that catalyze C–C bond formation followed by enzymatic amino transfer in highly controlled fashion by exploiting the enzymes’ high chemo-, regio- and enantioselectivity, while operating under mild reaction conditions. The project will span TRL 3-7 by incorporating demonstration reactions at technical scale (up to 10L reactor volume) carried out by industrial