Multiscale modelling of state transitions in the host-microbiome-brain network

Short-chain fatty-acids (SCFA) are produced from dietary fibres by the intestinal microbiota. They protect humans against obesity. The fate of SCFA and their impact on human fat metabolism is complex and dynamic. To optimally apply prebiotic (fibre) and probiotic (microbial) supplements, a better understanding of their mode of action is required. Our aim is to construct, infer, and analyse a dynamic, multiscale computational model predicting how dietary fibres affect the balance between fat intake and oxidation in human. The model will comprise production, uptake, and metabolism of SCFA and predict state transitions in whole-body fat metabolism in relation to obesity.

FAIRDOM PALs: No PALs for this Project

Project created: 21st Mar 2018

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