Ernst Wit

Short-chain fatty-acids (SCFA) are produced from dietary fibres by the intestinal microbiota. They protect humans against obesity. The fate of SCFA and their impact on human fat metabolism is complex and dynamic. To optimally apply prebiotic (fibre) and probiotic (microbial) supplements, a better understanding of their mode of action is required. Our aim is to construct, infer, and analyse a dynamic, multiscale computational model predicting how dietary fibres affect the balance between fat intake ...