Barbara Bakker

About Barbara Bakker:

I am a Professor in Medical Systems Biology and the University Medical Centre Groningen. The research in my lab is focused on complex regulation of mammalian lipid and carbohydrate metabolism, eventually aiming at network-based therapies. We combine dynamic computer simulations with quantitative metabolomics, 13C fluxomics, proteomics and transcriptome analysis, and in depth biochemical analysis. This allows to predict and understand ‘emergent’ properties, those properties that are counterintuitive when just looking at static pictures of pathways. We apply this approach to (i) inherited metabolic disease, (ii) the interplay between intestinal microbiota and host metabolism, (iii) the role of metabolism in ageing, and (iv) selective targeting of parasites or tumours without harming host metabolic function.

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