Comparing acyl-CoA dehydrogenase deficiencies

Based on odendaal1, a control model is made and compared to model deficient for short-chain acyl-CoA dehydrogenase (SCADD, 0%), medium-chain acyl-CoA dehydrogenase (MCADD, 0%), and very long-chain acyl-CoA dehydrogenase (VLCADD, 10%). With and withou metabolite partitioning, and with a fixed mitohondrial free CoASH. Generates Figures 3, 4, S1, S2, and S3 in the related paper.

Download "Model_notebooks.rar", unzip, and run: "7, Fig3+4+S1+S3-ACADDs-[needs-(1)]-20221109.nb" and "14, FigS2-ACADDs-constant-CoAMAT-[needs-(1)]-20221109.nb" after running "1, generate-model-20221109.nb"

SEEK ID: https://fairdomhub.org/assays/2073

Modelling Analysis

Christoff Odendaal

Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation

Investigation: Mitochondrial fatty acid oxidation in human liver

Study: Model analysis

Assay position: 1

Biological problem addressed: Model Analysis Type

Organisms: No organisms

Activity

Views: 331

Created: 7th Mar 2023 at 13:31

Last updated: 23rd Mar 2023 at 12:06

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