MCADD rescue titration

Incrementally increase the activity of some target rescue enzymes from 20% of default expression to 200% of default expression in a control and MCADD model to see if flux and CoASH concentration are rescued. Generates Fig. 6, S5, and S6.

Download "Model_notebooks.rar", unzip, and run "11, Fig6+S5-rescues-[needs-(1-and-10)]-20221109.nb", "10, Fig6B-inset-rescues-(low-acetylCoA)-[needs-(1)]-20221109.nb", and "16, FigS6-rescues-20221109-fixed-[needs-(1)]-CoASH.nb" after running "1, generate-model-20221109.nb"

SEEK ID: https://fairdomhub.org/assays/2074

Modelling analysis

Christoff Odendaal

Projects: PoLiMeR - Polymers in the Liver: Metabolism and Regulation

Investigation: Mitochondrial fatty acid oxidation in human liver

Study: Model analysis

Assay position: 3

Biological problem addressed: Model Analysis Type

Organisms: No organisms

Activity

Views: 377

Created: 7th Mar 2023 at 13:46

Last updated: 23rd Mar 2023 at 12:09

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