Since August 2008 I am professor in Systems Biology at the VU University Amsterdam. My Systems Bioinformatics group focusses on systems biology with a special focus on integrative bioinformatics. It aims at forming bridges between the classical bottom-up approaches in systems biology and the more data-driven approaches in classical bioinformatics. We combine experimental, modeling and theoretical approaches to study cellular physiology, with an emphasis on metabolic networks.
SEEK ID: https://fairdomhub.org/people/45
Expertise: genome-scale modeling, enzyme kinetics, Metabolic Pathway Analysis and Engineering Microbial Physiology Modeling of Biological Networks Industrial Systems Biotechnology White Biotech..., dynamics and control of biological networks
IMOMESIC - Integrating Modelling of Metabolism and Signalling towards an Application in Liver Cancer
One of the most challenging questions in cancer research is currently the interconnection of metabolism and signalling. An understanding of mechanisms that facilitate the physiological shift towards a proliferative metabolism in cancer cells is considered a major upcoming topic in oncology and is a key activity for future drug development. Due to the complexity of interrelations, a systems biology
A reconstruction of the cellular metabolism of the opportunistic human pathogen Enterococcus faecalis V583 represented as stoichiometric model and analysed using constraint-based modelling approaches
Contributor: Nadine Veith
Model type: Linear equations
Model format: SBML
Environment: Not specified
Organism: Enterococcus faecalis
Investigations: Investigation of glycolysis and pyruvate branch...
Modelling analyses: Genome-Scale Model Enterococcus faecalis V583
Date Published: 19th Dec 2014
Journal: Appl Environ Microbiol
PubMed ID: 25527553
Citation: Appl Environ Microbiol. 2015 Mar 1;81(5):1622-33. doi: 10.1128/AEM.03279-14. Epub 2014 Dec 19.
Date Published: 14th Feb 2012
Journal: The FEBS journal
PubMed ID: 22325620