Ligia Akemi Kiyuna
SEEK ID: https://fairdomhub.org/people/1369
Location:
Netherlands
ORCID:
https://orcid.org/0000-0002-9872-2102
Joined: 26th May 2019
Expertise: Not specified
Tools: Not specified
Their tagsRelated items
PoLiMeR is funded through the EU Marie Skłodowska-Curie Innovative Training Network (ITN), which drives scientific excellence and innovation. ITNs bring together universities, research institutes, industry and clinical partners from across the world to train researchers to doctorate level.
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease ...
Programme: This Project is not associated with a Programme
Public web page: http://polimer-itn.eu/
Validation of model's ability to predict oxygen consumption flux as measured usign permeabilised cells in an Oroboros Oxygraph. Generates Fig. 2A in the associated publication.
Download "Model_notebooks.rar", unzip, and run: "2, generate-model-Oroboros-validation-[needs(1)]-20221109.nb" and "4, Fig2A-Oroboros-simulation-data-[needs-(1-2-and-3)]-20221109.nb" after running "1, generate-model-20221109.nb"
Submitter: Christoff Odendaal
Biological problem addressed: Validation
Investigation: Mitochondrial fatty acid oxidation in human liver
Study: Model validation
Minireviews about each enzyme in the mitochindrial beta-oxidation model on which the final parameter choices (fixed-parameter model) and parameter sampling distributions (ensemble) were based.
Submitter: Christoff Odendaal
Biological problem addressed: Model Analysis Type
Investigation: Mitochondrial fatty acid oxidation in human liver
Study: Model construction
Protein measurement used to normalised the oxygen consumption flux measured on an Oroboros oxygraph.
Creators: Christoff Odendaal, Barbara Bakker, Ligia Akemi Kiyuna, Albert Gerding; Nicolette Huijkman; Marcel Vieira-Lara; Anne-Claire Martines
Submitter: Christoff Odendaal
DownloadMeasured in an Oroboros oxygraph.
Creators: Christoff Odendaal, Barbara Bakker, Ligia Akemi Kiyuna, Albert Gerding; Nicolette Huijkman; Marcel Vieira-Lara; Anne-Claire Martines
Submitter: Christoff Odendaal
Abstract (Expand)
Authors: Madhulika Singh, Ligia Akemi Kiyuna, Christoff Odendaal, Barbara M. Bakker, Amy C Harms, Thomas Hankemeier
Date Published: 11th Sep 2023
Publication Type: Journal
Abstract (Expand)
Authors: C. Odendaal, E. A. Jager, A. M. F. Martines, M. A. Vieira-Lara, N. C. A. Huijkman, L. A. Kiyuna, A. Gerding, J. C. Wolters, R. Heiner-Fokkema, K. van Eunen, T. G. J. Derks, B. M. Bakker
Date Published: 4th Sep 2023
Publication Type: Journal
L-carnitine as conserved moiety
Creators: Christoff Odendaal, Barbara Bakker, Ligia Akemi Kiyuna
Submitter: Christoff Odendaal
CoA as conserved moiety
Creators: Christoff Odendaal, Barbara Bakker, Ligia Akemi Kiyuna
Submitter: Christoff Odendaal
Acetyl-CoA in the mitochondrion as constant metabolite
Creators: Christoff Odendaal, Barbara Bakker, Ligia Akemi Kiyuna
Submitter: Christoff Odendaal
NADH and NAD+ (Nicotinamide adinine dinucleotide) as constant values.
Creators: Christoff Odendaal, Ligia Akemi Kiyuna, Barbara Bakker
Submitter: Christoff Odendaal
Oxidised and reduced electron transferring flavoprotein as constant values.
Creators: Christoff Odendaal, Barbara Bakker, Ligia Akemi Kiyuna
Submitter: Christoff Odendaal
Volume per mg mitochondrial protein of mitochondrion and cytosol.
Creators: Christoff Odendaal, Barbara Bakker, Ligia Akemi Kiyuna
Submitter: Christoff Odendaal
Medium-chain acyl-CoA dehydrogenase (EC 1.3.99.3)
Creators: Christoff Odendaal, Barbara Bakker, Ligia Akemi Kiyuna
Submitter: Christoff Odendaal
A short description of the experiments conducted to decide on HepG2 cells as the appropriate line for the generation of an MCAD knockout. IHH, Hep3B, HepG2, and HUH-7 cells were all consdered.
Creators: Christoff Odendaal, Barbara Bakker, Terry G.J. Derks, Ligia Akemi Kiyuna, Emmalie Jager
Submitter: Christoff Odendaal
