Mitochondrial fatty acid oxidation enzyme kinetics mini-reviews

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DOI: 10.15490/fairdomhub.1.assay.2137.3

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Created at: 24th Oct 2026 at 11:55

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Kinetics Minireviews

Minireviews about each enzyme in the mitochindrial beta-oxidation model on which the final parameter choices (fixed-parameter model) and parameter sampling distributions (ensemble) were based.

Contents

Parameter Search SOP

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Parameter search SOP.pdf

CPT1

Carnitine palmitoyltransferase 1 (EC 2.3.1.21)

1, CPT1.pdf

Equilibrium constants

The theory, calculations, and conditions that went into estimating the Keqs.

0, Theory - Estimating the equilibrium constants.pdf

CACT

Carnitine acylcarnitine translocase (UniProt: O43772)

2, CACT.pdf

CPT2

Carnitine palmitoyltransferase 2 (EC 2.3.1.21)

3, CPT2.pdf

CrAT

Carnitine acetyltransferase (EC 2.3.1.7)

4, CrAT.pdf

SCAD

Short-chain acyl-CoA dehydrogenase (EC 1.3.99.2)

5, SCAD.pdf

MCAD

Medium-chain acyl-CoA dehydrogenase (EC 1.3.99.3)

6, MCAD.pdf

VLCAD

Very long-chain acyl-CoA dehydrogenase (EC 1.3.8.9)

7, VLCAD.pdf

CROT

Crotonase / Enoyl-CoA hydratase (EC 4.2.1.17)

8, CROT.pdf

MSCHAD

Medium-/short-chain hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)

9, MSCHAD.pdf

MCKAT

Medium-chain ketoacyl-CoA thiolase (EC 2.3.1.16)

10, MCKAT.pdf

MTP

Mitochondrial trifunctional protein (UniProt: P40939)

11, MTP.pdf

ACOT

Acyl-CoA thioesterases (EC 3.1.2.1. and EC 3.1.2.2)

12, ACOT.pdf

Carnitine

L-carnitine as conserved moiety

13.1, CarMAT and CarCYT.pdf

CoA

CoA as conserved moiety

13.2, CoAMAT and CoACYT.pdf

Acetyl-CoA (mito)

Acetyl-CoA in the mitochondrion as constant metabolite

13.3, AcetylCoAMAT.pdf

NADH and NAD+

NADH and NAD+ (Nicotinamide adinine dinucleotide) as constant values.

13.4, NAD and NADH.pdf

ETF

Oxidised and reduced electron transferring flavoprotein as constant values.

13.5, ETF.pdf

Compartment volumes

Volume per mg mitochondrial protein of mitochondrion and cytosol.

13.6, Compartment Volumes.pdf

CrAT

Carnitine acetyltransferase - (EC 2.3.1.7)

4, CrAT.pdf

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Citation

Odendaal, Christoff, Bakker, Barbara, Kiyuna, Ligia Akemi, van Eunen, Karen, Jager, Emmalie, & Abegaz, Fentaw. (2026). Mitochondrial fatty acid oxidation enzyme kinetics mini-reviews. FAIRDOMHub. https://doi.org/10.15490/FAIRDOMHUB.1.ASSAY.2137.3

Snapshots

Mitochondrial fatty acid oxidation enzyme kinetics mini-reviews (24th Oct 2026) DOI

Snapshot 2 (2nd May 2026) DOI

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Created: 24th Oct 2026 at 11:55

Last updated: 24th Oct 2026 at 11:56

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