Projects

tba

Rhodolive

To systematically evaluate the general efficacy of nape acupuncture combined with rehabilitation training for the treatment of post-stroke dysphagia and in the recovery of swallowing function.

Aim of HUMET Startup Project is to make an inventory of expertise, research goals, resources etc. of the HUMET Coaliytion of the Willing.

Systems Biology as we know it is mostly terrestrial, i.e. it deals with mainstream Life on planet Earth. There are two exceptions. One is synthetic systems biology that designs other types of Life. The other exception studies the systems that may exist on other planets, or that exists at remote locations on planet Earth. Xenosystems Biology refers to the latter exception. At present this runs projects that deal with Life as found at remote locations on Earth, which are held representative of other ...

Old versions of files that cannot be deleted because they have been published.

Four ppt lecture files that are part of a UvA course on 'How to design an alien'. They correspond to four lectures given by Hans V. Westerhoff, September - October 2021

ONT+Illumina bacterial genome assembly project

Oxidative stress is an important mechanism of cerebral ischemia-reperfusion injury. Ferroptosis caused by iron overload after cerebral ischemia-reperfusion is considered a common cause of oxidative stress. A large number of recent studies have shown that electroacupuncture (EA) can regulate the expression of inflammatory factors, and the use of electroacupuncture preconditioning can produce a protective effect, which can reduce injury after cerebral ischemia and reperfusion. We aimed to assess ...

ORHIZON IS A PROPOSAL FOR A HORIZON EUROPE PROJECT (RIA) AIMED AT DELIVERING SOLUTIONS FOR ROOT AND RHIZOSPHERE TRAITS BASED BREEDING IN THE CONTEXT OF LOW INPUT AGRICULTURE AND CLIMAT CHANGE

Study on the mechanism of acupuncture combined with treadmill in treating apoplexy

With aging comes cellular senescence, and (multi-)morbidity. Cellular senescence is a key driver of an interconnected disease network including cancer and stroke. We wish to utilize systems modeling and bioinformatics, learning from omics and other lab data, to design and develop a biomarker + software kit with a focus on measuring and interpreting senescence-related signatures for precise (and early) diagnosis, prognosis, and, ultimately, therapy, of pancreatic cancer and ischemic stroke/thromboembolism. ...

Collection of coastal data via telemetry and sensors

genetical innovation

The Hippo signalling is a metabolic control pathway of cells proliferation and apoptosis, thus represents an emerging topic in tumour suppression regulation and regenerative medicine. This pathway is activated by anti-proliferative signals which come from the extracellular environment received by membranes proteins. In the cytosol compartment, the pathway is regulated by a phosphorylation cascade of four main proteins with Serin-Treonin kinase activity. At the end-point of this cascade the ...

OBJECTIVE: To summarise an overview of existing evidence between Chinese medicine and polycystic ovary syndrome (PCOS)，and to evaluate the strength and validity of these associations. METHODS: We retrieved systematic evaluations and meta-analyses of randomized controlled trials(RCT) evaluating Chinese herbal interventions in polycystic ovaries, including the use of decoctions or Chinese patent medicines. The quality of these systematic evaluations was evaluated using AMSTAR2 tools, while ovulation ...

Centre for Digital Life Norway (DLN) project 'OXYMOD - Optimized oxidative enzyme systems for efficient conversion of lignocellulose to valuable products'

In this project, we integrate COVID19 Disease Maps curated regulatory information in a macrophage logical model. This allows logical simulations of the effects of acute inflammation caused by the SARS-CoV-2 virus, both in general and in a cell-specific perspective. Moreover, understanding the regulatory network behavior of macrophages following infection opens new ways to test and predict drug and drug combination effects, as a first step towards the development of new treatments.

Data and experimental methods to support the work in the following paper:

Establishing Consensus Annotation for the Hallmarks of Cancer, 2020, Yi Chen, F.J.Verbeek and K.Wolstencroft, in submission