Multi-level mathematical modeling of erythropoiesis for optimized expansion of erythroid progenitor cells and improved treatment regimes
Programme: e:Bio
SEEK ID: https://fairdomhub.org/projects/54
Public web page: Not specified
Organisms: Homo sapiens, Mus musculus
FAIRDOM PALs: No PALs for this Project
Project created: 5th Oct 2016
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- People (17)
- Programmes (1)
- Institutions (5)
- Investigations (6)
- Studies (0+15)
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- Data files (0+42)
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- Publications (20)
- Presentations (0+11)
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Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: German Cancer Research Center (DKFZ)
https://orcid.org/0000-0002-0971-2309Expertise: Mathematical modelling, Single Cell analysis, Cell biology, Molecular Biology
Tools: Biochemistry, Systems Biology, Matlab, R
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: University of Freiburg
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: German Cancer Research Center (DKFZ)
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: University of Freiburg
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: German Cancer Research Center (DKFZ)
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: German Cancer Research Center (DKFZ)
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: German Cancer Research Center (DKFZ)
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: Roche Diagnostics
Projects: SysMO DB, FAIRDOM, ICYSB 2015 - International Practical Course in Systems Biology, de.NBI-SysBio, Regeneration and Repair in Acute-on-Chronic Liver Failure (LiSyM-ACLF - Pillar III), Early Metabolic Injury (LiSyM-EMI - Pillar I), Chronic Liver Disease Progression (LiSyM-DP - Pillar II), LiSyM Core Infrastructure and Management (LiSyM-PD), Liver Function Diagnostics (LiSyM-LiFuDi - Pillar IV), Molecular Steatosis - Imaging & Modeling (LiSyM-MSIM), Multi-Scale Models for Personalized Liver Function Tests (LiSyM-MM-PLF), Model Guided Pharmacotherapy In Chronic Liver Disease (LiSyM-MGP), The Hedgehog Signalling Pathway (LiSyM-JGMMS), Kinetics on the move - Workshop 2016, Example use cases, SBEpo - Systems Biology of Erythropoietin, FAIRDOM & LiSyM & de.NBI Data Structuring Training, MESI-STRAT, INCOME, EnzymeML, PoLiMeR - Polymers in the Liver: Metabolism and Regulation, MS_DILI, GMDS Project Group "FAIRe Dateninfrastrukturen für die Biomedizinische Informatik", COMBINE Multicellular Modelling, COVID-19 Disease Map, COVID-19 related studies and tools in Germany, nfdi4health - German National Research Data Infrastructure for Personal Health Data, NMTrypI - New Medicines for Trypanosomatidic Infections, ModeleXchange initiative, SNAPPER: Synergistic Neurotoxicology APP for Environmental Regulation, BioCreative VII, SDBV ephemeral data exchanges, The BeeProject, SDBV/HITS, MESI-STRAT Review, MESI-Review 2024, DeepCurate
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH)
https://orcid.org/0000-0002-4980-3512I am group leader of the SDBV (Scientific Databases and Visualisation) group at the HITS gGmbH, the Heidelberg Institute for Theoretical Studies.
I am interested in finding data. Starting with my master's thesis I have always worked on how to store data in a way that you can find it, and how to make sense out of data that has been stored.
Within FAIRDOM I find interesting to help people to store their data in a way that they make sense even after years.
Projects: SysMO-LAB, de.NBI-SysBio, Kinetics on the move - Workshop 2016, Example use cases, SBEpo - Systems Biology of Erythropoietin, FAIRDOM & LiSyM & de.NBI Data Structuring Training, FAIRDOM, EnzymeML, FAIRDOM Community Workers, GMDS Project Group "FAIRe Dateninfrastrukturen für die Biomedizinische Informatik", MIX-UP, COVID-19 Disease Map, ERNEST Mapping Group Pilot Study, CC-TOP, SABIO-VIS, SDBV/HITS
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH)
Expertise: Biochemistry, Molecular Biology, Microbiology, Phytopathology, Data curation
Within the de.NBI project my functions in the de.NBI-SysBio node comprise content curation, requirements elicitation, and community engagement for the users of biochemical reaction kinetics database SABIO-RK as well as of the data management platform SEEK.
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: University Hospital Heidelberg
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: German Cancer Research Center (DKFZ)
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: University of Freiburg
Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: University of Freiburg
https://orcid.org/0000-0003-2822-5191Projects: SBEpo - Systems Biology of Erythropoietin
Institutions: German Cancer Research Center (DKFZ)
Projects: de.NBI-SysBio, Kinetics on the move - Workshop 2016, Example use cases, SBEpo - Systems Biology of Erythropoietin, FAIRDOM & LiSyM & de.NBI Data Structuring Training, FAIRDOM, EnzymeML, GMDS Project Group "FAIRe Dateninfrastrukturen für die Biomedizinische Informatik", FAIRDOM Community Workers, MIX-UP, COVID-19 Disease Map, ERNEST Mapping Group Pilot Study, NMTrypI - New Medicines for Trypanosomatidic Infections, Standardization of enzyme-catalyzed reaction measurement, Standardization of enzyme-catalyzed reaction modelling, ModeleXchange initiative, CoVIDD - Coronavirus interactions in drug discovery - optimization and implementation, Mass spectrometry proteomics for biomarker discovery, Thymidylate synthase dimer dissociation, WG1 - Compound libraries coordination and integration of compound design, WG2 - Integration of early phase studies and low environmental impact actions, WG3 - Coordination of in vitro-to-in vivo translation of OneHealth leads and candidates, WG4 - Integration of R&D process-environmental studies and translation in informed whitepaper, WG5 - Promote dissemination, WG6 - Promote the transfer of knowledge, SABIO-VIS, SDBV/HITS
Institutions: Heidelberg Institute for Theoretical Studies (HITS gGmbH)
https://orcid.org/0000-0002-9077-5664Expertise: Biochemistry, Databases, Data Management, Curation
e:Bio - Innovations Competition Systems Biology
Projects: SulfoSys - Biotec, SBEpo - Systems Biology of Erythropoietin
Web page: http://www.fona.de/en/14276
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Abstract (Expand)
Authors: L. Adlung, S. Kar, M. C. Wagner, B. She, S. Chakraborty, J. Bao, S. Lattermann, M. Boerries, H. Busch, P. Wuchter, A. D. Ho, J. Timmer, M. Schilling, T. Hofer, U. Klingmuller
Date Published: 24th Jan 2017
Publication Type: Journal
PubMed ID: 28123004
Citation: Mol Syst Biol. 2017 Jan 24;13(1):904. doi: 10.15252/msb.20167258.
Abstract (Expand)
Authors: B. Steiert, J. Timmer, C. Kreutz
Date Published: 3rd Sep 2016
Publication Type: Not specified
PubMed ID: 27587694
Citation: Bioinformatics. 2016 Sep 1;32(17):i718-i726. doi: 10.1093/bioinformatics/btw461.
Abstract (Expand)
Authors: T. Maiwald, H. Hass, B. Steiert, J. Vanlier, R. Engesser, A. Raue, F. Kipkeew, H. H. Bock, D. Kaschek, C. Kreutz, J. Timmer
Date Published: 3rd Sep 2016
Publication Type: Not specified
PubMed ID: 27588423
Citation: PLoS One. 2016 Sep 2;11(9):e0162366. doi: 10.1371/journal.pone.0162366. eCollection 2016.
Abstract (Expand)
Authors: R. Merkle, B. Steiert, F. Salopiata, S. Depner, A. Raue, N. Iwamoto, M. Schelker, H. Hass, M. Wasch, M. E. Bohm, O. Mucke, D. B. Lipka, C. Plass, W. D. Lehmann, C. Kreutz, J. Timmer, M. Schilling, U. Klingmuller
Date Published: 6th Aug 2016
Publication Type: Journal
PubMed ID: 27494133
Citation: PLoS Comput Biol. 2016 Aug 5;12(8):e1005049. doi: 10.1371/journal.pcbi.1005049. eCollection 2016 Aug.
Abstract (Expand)
Authors: P. Wuchter, M. Vetter, R. Saffrich, A. Diehlmann, K. Bieback, A. D. Ho, P. Horn
Date Published: 26th Feb 2016
Publication Type: Journal
PubMed ID: 26911671
Citation: Exp Hematol. 2016 Jun;44(6):508-18. doi: 10.1016/j.exphem.2016.02.004. Epub 2016 Feb 19.
Abstract (Expand)
Authors: P. Wuchter, R. Saffrich, S. Giselbrecht, C. Nies, H. Lorig, S. Kolb, A. D. Ho, E. Gottwald
Date Published: 3rd Feb 2016
Publication Type: Journal
PubMed ID: 26829941
Citation: Cell Tissue Res. 2016 Jun;364(3):573-584. doi: 10.1007/s00441-015-2348-8. Epub 2016 Jan 30.
Abstract (Expand)
Authors: N. Iwamoto, L. A. D'Alessandro, S. Depner, B. Hahn, B. A. Kramer, P. Lucarelli, A. Vlasov, M. Stepath, M. E. Bohm, D. Deharde, G. Damm, D. Seehofer, W. D. Lehmann, U. Klingmuller, M. Schilling
Date Published: 2nd Feb 2016
Publication Type: Journal
PubMed ID: 26838549
Citation: Sci Signal. 2016 Feb 2;9(413):ra13. doi: 10.1126/scisignal.aab1967.
Abstract (Expand)
Authors: A. Raue, B. Steiert, M. Schelker, C. Kreutz, T. Maiwald, H. Hass, J. Vanlier, C. Tonsing, L. Adlung, R. Engesser, W. Mader, T. Heinemann, J. Hasenauer, M. Schilling, T. Hofer, E. Klipp, F. Theis, U. Klingmuller, B. Schoberl, J. Timmer
Date Published: 1st Nov 2015
Publication Type: Journal
PubMed ID: 26142188
Citation: Bioinformatics. 2015 Nov 1;31(21):3558-60. doi: 10.1093/bioinformatics/btv405. Epub 2015 Jul 3.
Abstract (Expand)
Authors: L. A. D'Alessandro, R. Samaga, T. Maiwald, S. H. Rho, S. Bonefas, A. Raue, N. Iwamoto, A. Kienast, K. Waldow, R. Meyer, M. Schilling, J. Timmer, S. Klamt, U. Klingmuller
Date Published: 24th Apr 2015
Publication Type: Journal
PubMed ID: 25905717
Citation: PLoS Comput Biol. 2015 Apr 23;11(4):e1004192. doi: 10.1371/journal.pcbi.1004192. eCollection 2015 Apr.
Abstract (Expand)
Authors: M. E. Boehm, L. Adlung, M. Schilling, S. Roth, U. Klingmuller, W. D. Lehmann
Date Published: 5th Dec 2014
Publication Type: Journal
PubMed ID: 25333863
Citation: J Proteome Res. 2014 Dec 5;13(12):5685-94. doi: 10.1021/pr5006923. Epub 2014 Nov 7.
Abstract (Expand)
Authors: G. Malcherek, N. Jin, A. G. Huckelhoven, J. Mani, L. Wang, U. Gern, A. Diehlmann, P. Wuchter, A. Schmitt, B. Chen, A. D. Ho, M. Schmitt
Date Published: 18th Sep 2014
Publication Type: Journal
PubMed ID: 25227910
Citation: Leukemia. 2014 Dec;28(12):2388-94. doi: 10.1038/leu.2014.273. Epub 2014 Sep 17.
Abstract (Expand)
Authors: Christian Tönsing, Jens Timmer, Clemens Kreutz
Date Published: 1st Aug 2014
Publication Type: Not specified
DOI: 10.1103/PhysRevE.90.023303
Citation: Phys. Rev. E 90(2)
Abstract (Expand)
Authors: P. Wuchter, K. Bieback, H. Schrezenmeier, M. Bornhauser, L. P. Muller, H. Bonig, W. Wagner, R. Meisel, P. Pavel, T. Tonn, P. Lang, I. Muller, M. Renner, G. Malcherek, R. Saffrich, E. C. Buss, P. Horn, M. Rojewski, A. Schmitt, A. D. Ho, R. Sanzenbacher, M. Schmitt
Date Published: 27th May 2014
Publication Type: Journal
PubMed ID: 24856898
Citation: Cytotherapy. 2015 Feb;17(2):128-39. doi: 10.1016/j.jcyt.2014.04.002. Epub 2014 May 20.
Abstract (Expand)
Authors: P. Wuchter, C. Leinweber, R. Saffrich, M. Hanke, V. Eckstein, A. D. Ho, M. Grunze, A. Rosenhahn
Date Published: 17th Dec 2013
Publication Type: Journal
PubMed ID: 24337688
Citation: Cell Tissue Res. 2014 Feb;355(2):315-26. doi: 10.1007/s00441-013-1759-7. Epub 2013 Dec 14.
Abstract (Expand)
Authors: M. Hanke, I. Hoffmann, C. Christophis, M. Schubert, V. T. Hoang, A. Zepeda-Moreno, N. Baran, V. Eckstein, P. Wuchter, A. Rosenhahn, A. D. Ho
Date Published: 26th Nov 2013
Publication Type: Journal
PubMed ID: 24269154
Citation: Biomaterials. 2014 Feb;35(5):1411-9. doi: 10.1016/j.biomaterials.2013.11.011. Epub 2013 Nov 22.
Abstract (Expand)
Authors: A. Ludwig, R. Saffrich, V. Eckstein, T. Bruckner, W. Wagner, A. D. Ho, P. Wuchter
Date Published: 15th Oct 2013
Publication Type: Journal
PubMed ID: 24119647
Citation: Cytotherapy. 2014 Jan;16(1):111-21. doi: 10.1016/j.jcyt.2013.07.007. Epub 2013 Oct 10.
Abstract
Authors: M. Schmitt, L. P. Muller, G. Keysser, H. M. Lorenz, A. D. Ho, P. Wuchter
Date Published: 6th Sep 2013
Publication Type: Journal
PubMed ID: 24006170
Citation: Dtsch Med Wochenschr. 2013 Sep;138(37):1852-5. doi: 10.1055/s-0033-1343346. Epub 2013 Sep 4.
Abstract (Expand)
Authors: L. Shi, L. Jong, U. Wittig, P. Lucarelli, M. Stepath, S. Mueller, L. A. D'Alessandro, U. Klingmuller, W. Muller
Date Published: 3rd Apr 2013
Publication Type: Journal
PubMed ID: 23549603
Citation: J Integr Bioinform. 2013 Apr 3;10(2):220. doi: 10.2390/biecoll-jib-2013-220.
Abstract (Expand)
Authors: V. Becker, M. Schilling, J. Bachmann, U. Baumann, A. Raue, T. Maiwald, J. Timmer, U. Klingmuller
Date Published: 11th Jun 2010
Publication Type: Journal
PubMed ID: 20488988
Citation: Science. 2010 Jun 11;328(5984):1404-8. doi: 10.1126/science.1184913. Epub 2010 May 20.
Abstract (Expand)
Authors: M. Schilling, T. Maiwald, S. Bohl, M. Kollmann, C. Kreutz, J. Timmer, U. Klingmuller
Date Published: 13th Dec 2005
Publication Type: Journal
PubMed ID: 16336276
Citation: FEBS J. 2005 Dec;272(24):6400-11. doi: 10.1111/j.1742-4658.2005.05037.x.