Mesenchymal stromal cells inhibit proliferation of virus-specific CD8(+) T cells.


Mesenchymal stromal cells (MSCs) possess broad immunomodulatory capacities that are currently investigated for potential clinical application in treating autoimmune disorders. Third-party MSCs suppress alloantigen-induced proliferation of peripheral blood mononuclear cells providing the rationale for clinical use in graft-versus-host disease (GvHD). We confirmed that MSCs strongly inhibited proliferation of CD8(+) T cells in a mixed lymphocyte reaction. However, MSCs also suppressed proliferation of T cells specifically recognizing cytomegalovirus (CMV) and influenza virus. Inhibition was dose dependent, but independent of the culture medium. MSCs inhibited proliferation of specific CD8(+) T cells and the release of IFN-gamma by specific CD8(+) T cells for immunodominant HLA-A2- and HLA-B7- restricted antigen epitopes derived from CMV phosphoprotein 65 and influenza matrix protein. This is in contrast to a recently reported scenario where MSCs exert differential effects on alloantigen and virus-specific T cells potentially having an impact on surveillance and prophylaxis of patients treated by MSCs.


PubMed ID: 25227910

Projects: SBEpo - Systems Biology of Erythropoietin

Publication type: Journal

Journal: Leukemia

Citation: Leukemia. 2014 Dec;28(12):2388-94. doi: 10.1038/leu.2014.273. Epub 2014 Sep 17.

Date Published: 18th Sep 2014

Registered Mode: Not specified

Authors: G. Malcherek, N. Jin, A. G. Huckelhoven, J. Mani, L. Wang, U. Gern, A. Diehlmann, P. Wuchter, A. Schmitt, B. Chen, A. D. Ho, M. Schmitt

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Created: 13th Oct 2016 at 12:11

Last updated: 3rd Aug 2020 at 18:40

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