Selected:
SBEpo - Systems Biology of Erythropoietin (Project)
Description: Multi-level mathematical modeling of erythropoiesis for optimized expansion of erythroid progenitor cells and improved...
SEEK ID: https://fairdomhub.org/projects/54
Description: Multi-level mathematical modeling of erythropoiesis for optimized expansion of erythroid progenitor cells and improved...
SEEK ID: https://fairdomhub.org/projects/54
- e:Bio
- SulfoSys - Biotec
- SBEpo - Systems Biology of Erythropoietin
- WP1: Integration of Epo-induced Signal Transduction
- Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling.
- Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation.
- Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems.
- Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.
- Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells.
- Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation.
- WP2: Link of Signal Transduction to Gene Regulatory Network
- WP3: Cell Fate Decisions of Erythroid Progenitor Cells
- WP4: Cross-talk with Modulators - Epo with TGFß and Novel Factors
- WP5: Translational Application for the Characterization and ex vivo Expansion of Human Erythroid Progenitor Cells
- Evaluation of GMP-compliant culture media for in vitro expansion of human bone marrow mesenchymal stromal cells.
- Microcavity arrays as an in vitro model system of the bone marrow niche for hematopoietic stem cells.
- Mesenchymal stromal cells inhibit proliferation of virus-specific CD8(+) T cells.
- Standardization of Good Manufacturing Practice-compliant production of bone marrow-derived human mesenchymal stromal cells for immunotherapeutic applications.
- Plerixafor induces the rapid and transient release of stromal cell-derived factor-1 alpha from human mesenchymal stromal cells and influences the migration behavior of human hematopoietic progenitor cells.
- Differences between healthy hematopoietic progenitors and leukemia cells with respect to CD44 mediated rolling versus adherence behavior on hyaluronic acid coated surfaces.
- Functional potentials of human hematopoietic progenitor cells are maintained by mesenchymal stromal cells and not impaired by plerixafor.
- [Mesenchymal stroma cells (MSCs) for the treatment of rheumatic disease].
- Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation.
- Data Management and Data Standardization
- Covering a broad dynamic range: information processing at the erythropoietin receptor.
- Excemplify: a flexible template based solution, parsing and managing data in spreadsheets for experimentalists.
- Computational processing and error reduction strategies for standardized quantitative data in biological networks.
- Cause and cure of sloppiness in ordinary differential equation models
- L1 regularization facilitates detection of cell type-specific parameters in dynamical systems
- Driving the Model to Its Limit: Profile Likelihood Based Model Reduction
- WP1: Integration of Epo-induced Signal Transduction