Ulrike Wittig

SDBV group using Hub

FAIRDOM will establish a support and service network for European Systems Biology. We will serve projects in standardising, managing and disseminating data and models in a FAIR manner: Findable, Accessible, Interoperable and Reusable.

The main idea of MIX-UP (MIXed plastics biodegradation and UPcycling using microbial communities) is to showcase a novel approach for plastic recycling and therefore addresses one of the greatest challenges of our time: the establishment of a circular (bio)-economy for plastics. The continuing demand for plastic products, the lack of appropriate recycling and the ubiquitous pollution of the environment with plastic waste pose a global challenge. An ambitious vision and considerable efforts are ...

The GMDS project group bundles activities for health-related FAIR data infrastructures in the fields of biomedical research, clinical data management and medical informatics in Germany. It aims at providing a platform for information exchange about best practice for and implementation of FAIR data management in these fields and constructing a network of FAIR data managements providers in these fields. Through bridging between providers and potential users of such data management platforms within ...

The workshop focuses on the publication, curation, retrieval, and usage of kinetic data from the reaction kinetics database SABIO-RK and on the use of data in modeling. There will be experience reports from scientists who successfully used experimental data to formulate or verify biological hypotheses with the computer, and you will experience how experimental data can be used with computational models.

Multi-level mathematical modeling of erythropoiesis for optimized expansion of erythroid progenitor cells and improved treatment regimes

The Systems Biology Service Center of de.NBI (de.NBI-SysBio) provides bioinformatics support and a standards-based data management for systems biology projects, with focus on the provenance of experimental results and on the reproducibility of modeling experiments, as well as high-quality curated biochemical data to modelers and experimentalists. The node concentrates on two tools for the data management in life sciences research: SEEK, a catalogue for storage, registration and exchange of data ...

Collection of training material for SEEK/FAIRDOMHub

Here we share resources and best practices to develop a disease map for COVID-19. The project is progressing as a broad community-driven effort. We aim to establish a knowledge repository on virus-host interaction mechanisms specific to the SARS-CoV-2. The COVID-19 Disease Map is an assembly of molecular interaction diagrams established based on literature evidence.

The New Medicines for Trypanosomatidic Infections - NMTrypI project aimed at obtaining new candidate drugs against Trypanosomatidic infections with appropriate efficiency from the lead phase to the final preclinical phase that are more accessible to patients.

In the CoVIDD project, we aim at unravelling interactions of viral proteins with the cellular factors and the host pathways involved in SARS-CoV-2 infection by a combination of modern technologies, genomics, proteomics, structural biology, chemoinformatics and drug discovery. To effectively search for drugs that could modify viral replication we need to know what human proteins and viral proteins interact. Thus, a comprehensive virus-host protein interaction network will help us to identify the ...

Supplementary material for "Mass spectrometry proteomic and network enrichment analysis to track FOLFOX response in drug resistant ovarian carcinoma"

Presentation at the ELIXIR-CONVERGE "2nd online community event for life scientists involved or interested in DM/DS training"

https://www.denbi.de/de-nbi-events/1418-2nd-online-community-event-for-cop-in-dm-ds-training

The workshop “Novel leads and drugs and their mechanism of action in the field of vector borne parasitic disease” is jointly organized by WG1 “Compound libraries coordination and integration of compound design” and WG2 “Integration of early phase studies and low environmental impact actions” of the COST Action CA21111 OneHealthDrugs. The focus of the workshop is to bring together experts to report and discuss common definitions of novel leads and drugs and their mechanisms of action in view also ...

Agenda:

• 14:00 - Welcome
• 14:10 - Ulrich Sax (University Medical Center Göttingen, Germany) "A translational use case for SEEK in current cancer research"
• 14:30 - Dagmar Waltemath (University Medicine Greifswald, Germany) "Managing computational models in biology and medicine: Experiences from running FAIRDOMHubs in the COMBINE and Medical Informatics communities"
• 14:50 - Jacky Snoep (Stellenbosch University, South Africa) _"Running reproducible modelling projects on the ...

Agenda:

• 14:00 - Welcome
• 14:10 - Marek Ostaszewski (Luxembourg Centre for Systems Biomedicine, LU): “FAIRDOMHub - a platform for the research community building the COVID-19 Disease Map”
• 14:30 - Sara El-Gebali (SciLifeLab Data Centre, SE): “Samples Metadata at the SciLifeLab”
• 14:50 - Huiming Ding (Massachusetts Institute of Technology, US): “Creating mutable samples using NExtSEEK”
• 15:10 - Rafael Andrade Buono (VIB, BE): “DataHub: focusing on sample metadata”
• 15:30 - Discussion

The purpose of a new series of user meetings is to establish an active FAIRDOM user community to allow networking between various FAIRDOM-SEEK users and learn from each other’s experiences. Within the two-hours event the FAIRDOM team will give an introduction on current developments and the invited users will showcase the use of FAIRDOMHub and other FAIRDOM-SEEK instances for their research projects.

Invited speakers: Cyril Pommier, Frank Meineke, Jasper Koehorst, Andrej Blejec

This survey is organized by WG1 (Compound libraries coordination and integration of compound design) of COST Action CA21111 "OneHealthDrugs" and collects information from COST Action members about the handling of chemical compound information and the usage of compound databases/repositories. The results will help to coordinate and integrate compound data from different resources for searching and screening purposes by the COST Action participants.